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The influence of sex steroid hormone...

Matousek, Rose H.

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The influence of sex steroid hormones on cognition in normative and clinical populations of older men.

Record Type:	Language materials, printed : Monograph/item
Title/Author:	The influence of sex steroid hormones on cognition in normative and clinical populations of older men./
Author:	Matousek, Rose H.
Description:	194 p.
Notes:	Source: Dissertation Abstracts International, Volume: 70-08, Section: B, page: 5225.
Contained By:	Dissertation Abstracts International70-08B.
Subject:	Psychology, Psychobiology. -
Online resource:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=NR50955
ISBN:	9780494509555

The influence of sex steroid hormones on cognition in normative and clinical populations of older men.
Matousek, Rose H.

The influence of sex steroid hormones on cognition in normative and clinical populations of older men. - 194 p.

Source: Dissertation Abstracts International, Volume: 70-08, Section: B, page: 5225.

Thesis (Ph.D.)--McGill University (Canada), 2008.

The main goal of this dissertation was to investigate whether changes in sex steroid hormone levels were associated with changes in cognitive function in both healthy and clinical populations of elderly men. Study 1 was an exploratory investigation of the hormonal correlates of a wide variety of cognitive functions in healthy, older men whose mean age was 69 years. Its results demonstrated that endogenous levels of testosterone were related to performance on spatial tasks in a curvilinear fashion, while a similar curvilinear association related endogenous levels of estradiol to performance on verbal tasks. However, because of the correlational nature of the study, causation could not be determined. In order to further investigate the effects of sex steroid hormones on cognitive test performance in men, a randomized, placebo-controlled treatment study was undertaken. Study 2 was designed to investigate the individual effects of testosterone and estrogen on cognition in a clinical population of elderly men with prostate cancer who were about to be treated with a gonadotropin releasing-hormone analog (GnRH) that causes pharmacological suppression of testicular function. After 12 weeks of testicular suppression, "add-back" estrogen or placebo was randomly administered concurrent with GnRH administration for an additional 12 weeks. These pharmacologic endocrine manipulations allowed the isolation of the effects of estrogen on cognition in men with prostate cancer. In contradistinction to the hypotheses, no significant changes in cognitive performance were found in these men following 12-weeks of testicular suppression with a GnRH analog despite significant treatment-related changes in their sex hormone levels, and a detrimental effect of 12-weeks of add-back estradiol treatment was observed on verbal memory instead of the hypothesized beneficial effect. The failure to find the expected results of the hormonal manipulations on cognitive functions in the men with prostate cancer may be a result of the short duration of treatments, the oral route of estradiol administration, the confounding effects of hypogonadism on sex steroid hormone receptor responsiveness and/or comorbid health conditions on cognition. Taken together, the results of these two studies suggest that hormone-cognition relationships in both healthy men and in men with prostate cancer are complex and need to be interpreted within the context of age-related changes in sex steroid hormone dynamics and brain function.

ISBN: 9780494509555Subjects--Topical Terms:

1017821
Psychology, Psychobiology.

The influence of sex steroid hormones on cognition in normative and clinical populations of older men.
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245 1 4 $a The influence of sex steroid hormones on cognition in normative and clinical populations of older men.
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500 $a Source: Dissertation Abstracts International, Volume: 70-08, Section: B, page: 5225.
502 $a Thesis (Ph.D.)--McGill University (Canada), 2008.
520 $a The main goal of this dissertation was to investigate whether changes in sex steroid hormone levels were associated with changes in cognitive function in both healthy and clinical populations of elderly men. Study 1 was an exploratory investigation of the hormonal correlates of a wide variety of cognitive functions in healthy, older men whose mean age was 69 years. Its results demonstrated that endogenous levels of testosterone were related to performance on spatial tasks in a curvilinear fashion, while a similar curvilinear association related endogenous levels of estradiol to performance on verbal tasks. However, because of the correlational nature of the study, causation could not be determined. In order to further investigate the effects of sex steroid hormones on cognitive test performance in men, a randomized, placebo-controlled treatment study was undertaken. Study 2 was designed to investigate the individual effects of testosterone and estrogen on cognition in a clinical population of elderly men with prostate cancer who were about to be treated with a gonadotropin releasing-hormone analog (GnRH) that causes pharmacological suppression of testicular function. After 12 weeks of testicular suppression, "add-back" estrogen or placebo was randomly administered concurrent with GnRH administration for an additional 12 weeks. These pharmacologic endocrine manipulations allowed the isolation of the effects of estrogen on cognition in men with prostate cancer. In contradistinction to the hypotheses, no significant changes in cognitive performance were found in these men following 12-weeks of testicular suppression with a GnRH analog despite significant treatment-related changes in their sex hormone levels, and a detrimental effect of 12-weeks of add-back estradiol treatment was observed on verbal memory instead of the hypothesized beneficial effect. The failure to find the expected results of the hormonal manipulations on cognitive functions in the men with prostate cancer may be a result of the short duration of treatments, the oral route of estradiol administration, the confounding effects of hypogonadism on sex steroid hormone receptor responsiveness and/or comorbid health conditions on cognition. Taken together, the results of these two studies suggest that hormone-cognition relationships in both healthy men and in men with prostate cancer are complex and need to be interpreted within the context of age-related changes in sex steroid hormone dynamics and brain function.
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