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MicroRNA machinery as an integral co...

Carpio, Lawrence L.

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MicroRNA machinery as an integral component of viral transcription mechanisms and drug efficacy.

Record Type:	Language materials, printed : Monograph/item
Title/Author:	MicroRNA machinery as an integral component of viral transcription mechanisms and drug efficacy./
Author:	Carpio, Lawrence L.
Description:	73 p.
Notes:	Source: Masters Abstracts International, Volume: 48-03, page: 1523.
Contained By:	Masters Abstracts International48-03.
Subject:	Biology, Virology. -
Online resource:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=1473529
ISBN:	9781109567373

MicroRNA machinery as an integral component of viral transcription mechanisms and drug efficacy.
Carpio, Lawrence L.

MicroRNA machinery as an integral component of viral transcription mechanisms and drug efficacy. - 73 p.

Source: Masters Abstracts International, Volume: 48-03, page: 1523.

Thesis (M.S.)--The George Washington University, 2010.

Human immunodeficiency virus is the foremost cause of acquired immunodeficiency syndrome. The current treatments do not focus on how in latent cells, the virus could still mutate. A drug resistant virus within the host will eventually lead to AIDS. Researchers must gain an appreciation of how latent cells function to keep the virus alive and away from immune response. In recent findings, the ability of HIV-1 to create its own viral microRNA from the TAR hairpin element is important for manipulating host cell mechanisms and maintaining latency. HIV-1 manipulates host cell mechanisms, such as cyclin dependent kinases and their corresponding cyclin elements, to suppress apoptotic cellular pathways and to maintain a latent infection. The therapeutic focus now turns to developing effective cdk inhibitors that eliminate viral replication, but do not affect normal cellular mechanisms. To do this, researchers need to understand the importance of how RNAi plays a role in viral activation and drug efficacy. A thorough understanding of HIV-1 microRNA pathways and latency could lead to alternative treatment options for HIV-1 infection.

ISBN: 9781109567373Subjects--Topical Terms:

1019068
Biology, Virology.

MicroRNA machinery as an integral component of viral transcription mechanisms and drug efficacy.
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020 $a 9781109567373
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100 1 $a Carpio, Lawrence L. $3 1669104
245 1 0 $a MicroRNA machinery as an integral component of viral transcription mechanisms and drug efficacy.
300 $a 73 p.
500 $a Source: Masters Abstracts International, Volume: 48-03, page: 1523.
500 $a Adviser: Fatah Kashanchi.
502 $a Thesis (M.S.)--The George Washington University, 2010.
520 $a Human immunodeficiency virus is the foremost cause of acquired immunodeficiency syndrome. The current treatments do not focus on how in latent cells, the virus could still mutate. A drug resistant virus within the host will eventually lead to AIDS. Researchers must gain an appreciation of how latent cells function to keep the virus alive and away from immune response. In recent findings, the ability of HIV-1 to create its own viral microRNA from the TAR hairpin element is important for manipulating host cell mechanisms and maintaining latency. HIV-1 manipulates host cell mechanisms, such as cyclin dependent kinases and their corresponding cyclin elements, to suppress apoptotic cellular pathways and to maintain a latent infection. The therapeutic focus now turns to developing effective cdk inhibitors that eliminate viral replication, but do not affect normal cellular mechanisms. To do this, researchers need to understand the importance of how RNAi plays a role in viral activation and drug efficacy. A thorough understanding of HIV-1 microRNA pathways and latency could lead to alternative treatment options for HIV-1 infection.
590 $a School code: 0075.
650 4 $a Biology, Virology. $3 1019068
690 $a 0720
710 2 $a The George Washington University. $b Genomics and Bioinformatics. $3 1669105
773 0 $t Masters Abstracts International $g 48-03.
790 1 0 $a Kashanchi, Fatah, $e advisor
790 1 0 $a Kehn-Hall, Kylene $e committee member
790 $a 0075
791 $a M.S.
792 $a 2010
856 4 0 $u http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=1473529