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Phylogenetic analysis of swine influ...

Padmanabhan, Rangarajan.

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Phylogenetic analysis of swine influenza viruses isolated from humans in Alma-Ata, Kazakhstan.

Record Type:	Language materials, printed : Monograph/item
Title/Author:	Phylogenetic analysis of swine influenza viruses isolated from humans in Alma-Ata, Kazakhstan./
Author:	Padmanabhan, Rangarajan.
Description:	86 p.
Notes:	Source: Masters Abstracts International, Volume: 47-06, page: 3444.
Contained By:	Masters Abstracts International47-06.
Subject:	Biology, Virology. -
Online resource:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=1465517
ISBN:	9781109215588

Phylogenetic analysis of swine influenza viruses isolated from humans in Alma-Ata, Kazakhstan.
Padmanabhan, Rangarajan.

Phylogenetic analysis of swine influenza viruses isolated from humans in Alma-Ata, Kazakhstan. - 86 p.

Source: Masters Abstracts International, Volume: 47-06, page: 3444.

Thesis (M.S.)--University of Maryland, College Park, 2009.

Continuous surveillance of influenza becomes important considering the economic, epidemic and pandemic implications of influenza infections. This study details phylogenetic & molecular analysis of the genes of four swine influenza viruses isolated from humans in Alma-Ata, Kazakhstan. Phylogenetic analysis placed the eight segments of the four viruses in the classical H1N1 swine clade, along with the isolate A/sw/Jamesburg/1942, except for the HA of A/Alma-Ata/32/98, which was placed in the human H1N1 lineage, along with the isolate A/WS/1933. On amino acid analysis, the viruses displayed mutations on HA and ribonucleoproteins which putatively disrupt antigenic recognition of the virus by the host immune system. The presence of these viruses relatively unchanged for 6 decades after their initial isolation could be speculated to be a combination of laboratory leaks in southern USSR in 1980s, low divergence of classical H1N1 viruses in pigs, and the low population density of Kazakhstan.

ISBN: 9781109215588Subjects--Topical Terms:

1019068
Biology, Virology.

Phylogenetic analysis of swine influenza viruses isolated from humans in Alma-Ata, Kazakhstan.
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100 1 $a Padmanabhan, Rangarajan. $3 1669093
245 1 0 $a Phylogenetic analysis of swine influenza viruses isolated from humans in Alma-Ata, Kazakhstan.
300 $a 86 p.
500 $a Source: Masters Abstracts International, Volume: 47-06, page: 3444.
500 $a Adviser: Daniel Perez.
502 $a Thesis (M.S.)--University of Maryland, College Park, 2009.
520 $a Continuous surveillance of influenza becomes important considering the economic, epidemic and pandemic implications of influenza infections. This study details phylogenetic & molecular analysis of the genes of four swine influenza viruses isolated from humans in Alma-Ata, Kazakhstan. Phylogenetic analysis placed the eight segments of the four viruses in the classical H1N1 swine clade, along with the isolate A/sw/Jamesburg/1942, except for the HA of A/Alma-Ata/32/98, which was placed in the human H1N1 lineage, along with the isolate A/WS/1933. On amino acid analysis, the viruses displayed mutations on HA and ribonucleoproteins which putatively disrupt antigenic recognition of the virus by the host immune system. The presence of these viruses relatively unchanged for 6 decades after their initial isolation could be speculated to be a combination of laboratory leaks in southern USSR in 1980s, low divergence of classical H1N1 viruses in pigs, and the low population density of Kazakhstan.
590 $a School code: 0117.
650 4 $a Biology, Virology. $3 1019068
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710 2 $a University of Maryland, College Park. $b Cell Biology & Molecular Genetics. $3 1028978
773 0 $t Masters Abstracts International $g 47-06.
790 1 0 $a Perez, Daniel, $e advisor
790 1 0 $a DeStefano, Jeffrey $e committee member
790 1 0 $a Zhang, Yanjin $e committee member
790 $a 0117
791 $a M.S.
792 $a 2009
856 4 0 $u http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=1465517