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Construction of a dual infection mec...

Piekarski, Joseph Matthew.

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Construction of a dual infection mechanism for HIV.

Record Type:	Language materials, printed : Monograph/item
Title/Author:	Construction of a dual infection mechanism for HIV./
Author:	Piekarski, Joseph Matthew.
Description:	148 p.
Notes:	Source: Masters Abstracts International, Volume: 47-06, page: 3444.
Contained By:	Masters Abstracts International47-06.
Subject:	Biology, Virology. -
Online resource:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=1465379
ISBN:	9781109187526

Construction of a dual infection mechanism for HIV.
Piekarski, Joseph Matthew.

Construction of a dual infection mechanism for HIV. - 148 p.

Source: Masters Abstracts International, Volume: 47-06, page: 3444.

Thesis (M.S.)--University of Maryland, Baltimore County, 2009.

In this work, we created three mathematical models to describe HIV infection. Our goal was to investigate the effectiveness of cell-to-cell infection via "virological synapses" through the designed models. The combination of cell-to-cell infection and free-floating virus mechanisms in mathematical models has not been investigated as of yet. We evaluated the two models using three statistical techniques, and decided to use a weighted summation of squares to compare our projected results to published experimental data. The analysis found that the addition of a cell-to-cell infection mechanism did not hinder the predictability of HIV markers for disease progression and showed cell-to-cell infection was most significant early on in infection. In our last model, we further investigated the mechanisms responsible for T cell depletion. Many theories have been published hypothesizing the cause of immune failure. These range from heightened activation of T cells, cytotoxic virions and the eventual destruction due to productive infection. In our model, we observed that the majority of cells die due to the direct result of infection.

ISBN: 9781109187526Subjects--Topical Terms:

1019068
Biology, Virology.

Construction of a dual infection mechanism for HIV.
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020 $a 9781109187526
035 $a (UMI)AAI1465379
035 $a AAI1465379
040 $a UMI $c UMI
100 1 $a Piekarski, Joseph Matthew. $3 1669091
245 1 0 $a Construction of a dual infection mechanism for HIV.
300 $a 148 p.
500 $a Source: Masters Abstracts International, Volume: 47-06, page: 3444.
500 $a Adviser: Mariajose Castellanos.
502 $a Thesis (M.S.)--University of Maryland, Baltimore County, 2009.
520 $a In this work, we created three mathematical models to describe HIV infection. Our goal was to investigate the effectiveness of cell-to-cell infection via "virological synapses" through the designed models. The combination of cell-to-cell infection and free-floating virus mechanisms in mathematical models has not been investigated as of yet. We evaluated the two models using three statistical techniques, and decided to use a weighted summation of squares to compare our projected results to published experimental data. The analysis found that the addition of a cell-to-cell infection mechanism did not hinder the predictability of HIV markers for disease progression and showed cell-to-cell infection was most significant early on in infection. In our last model, we further investigated the mechanisms responsible for T cell depletion. Many theories have been published hypothesizing the cause of immune failure. These range from heightened activation of T cells, cytotoxic virions and the eventual destruction due to productive infection. In our model, we observed that the majority of cells die due to the direct result of infection.
590 $a School code: 0434.
650 4 $a Biology, Virology. $3 1019068
690 $a 0720
710 2 $a University of Maryland, Baltimore County. $b Engineering, Chemical and Biochemical. $3 1669092
773 0 $t Masters Abstracts International $g 47-06.
790 1 0 $a Castellanos, Mariajose, $e advisor
790 1 0 $a Frey, Douglas D. $e committee member
790 1 0 $a Good, Theresa $e committee member
790 $a 0434
791 $a M.S.
792 $a 2009
856 4 0 $u http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=1465379