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The role of subunit 9 in the structu...

Gulde, Paul Elliot.

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The role of subunit 9 in the structure, function and regulation of the Trypanosoma brucei ATP synthase.

Record Type:	Language materials, printed : Monograph/item
Title/Author:	The role of subunit 9 in the structure, function and regulation of the Trypanosoma brucei ATP synthase./
Author:	Gulde, Paul Elliot.
Description:	131 p.
Notes:	Source: Dissertation Abstracts International, Volume: 71-02, Section: B, page: 0851.
Contained By:	Dissertation Abstracts International71-02B.
Subject:	Biology, Microbiology. -
Online resource:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3391043
ISBN:	9781109625417

The role of subunit 9 in the structure, function and regulation of the Trypanosoma brucei ATP synthase.
Gulde, Paul Elliot.

The role of subunit 9 in the structure, function and regulation of the Trypanosoma brucei ATP synthase. - 131 p.

Source: Dissertation Abstracts International, Volume: 71-02, Section: B, page: 0851.

Thesis (Ph.D.)--State University of New York at Buffalo, 2010.

The Trypanosoma brucei ATP synthase functions as a hydrolase in bloodstream form parasites and as a synthase in the procyclic form parasites. The dual functionality of the complex enables the parasite to maintain the membrane potential in both environments. This study focuses on the role of the F0 component subunit 9 in the structure, function and regulation of the ATP synthase. We have shown that the T. brucei produces two isoforms of S9 (S9-1 and S9-2). Each isoform is differentially regulated. Both isoforms are incorporated into the ATP synthase, within the same F0 component. Expression of each isoform was decreased by RNA interference, however, S9-2 increased initially in response to RNAi before ultimately decreasing. Loss of S9 results in a loss in the ATP synthase complex and, interestingly, a loss in the complexes of the electron transport chain. This results in an unexpected loss of membrane potential in the procyclic cells. Loss of S9 also results in a decrease in the alpha and beta subunits expression at the transcript and protein levels. This suggests that S9 plays a major role in the regulation of the ATP synthase and other mitochondrial complexes.

ISBN: 9781109625417Subjects--Topical Terms:

1017734
Biology, Microbiology.

The role of subunit 9 in the structure, function and regulation of the Trypanosoma brucei ATP synthase.
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020 $a 9781109625417
035 $a (UMI)AAI3391043
035 $a AAI3391043
040 $a UMI $c UMI
100 1 $a Gulde, Paul Elliot. $3 1669050
245 1 4 $a The role of subunit 9 in the structure, function and regulation of the Trypanosoma brucei ATP synthase.
300 $a 131 p.
500 $a Source: Dissertation Abstracts International, Volume: 71-02, Section: B, page: 0851.
500 $a Adviser: Noreen Williams.
502 $a Thesis (Ph.D.)--State University of New York at Buffalo, 2010.
520 $a The Trypanosoma brucei ATP synthase functions as a hydrolase in bloodstream form parasites and as a synthase in the procyclic form parasites. The dual functionality of the complex enables the parasite to maintain the membrane potential in both environments. This study focuses on the role of the F0 component subunit 9 in the structure, function and regulation of the ATP synthase. We have shown that the T. brucei produces two isoforms of S9 (S9-1 and S9-2). Each isoform is differentially regulated. Both isoforms are incorporated into the ATP synthase, within the same F0 component. Expression of each isoform was decreased by RNA interference, however, S9-2 increased initially in response to RNAi before ultimately decreasing. Loss of S9 results in a loss in the ATP synthase complex and, interestingly, a loss in the complexes of the electron transport chain. This results in an unexpected loss of membrane potential in the procyclic cells. Loss of S9 also results in a decrease in the alpha and beta subunits expression at the transcript and protein levels. This suggests that S9 plays a major role in the regulation of the ATP synthase and other mitochondrial complexes.
590 $a School code: 0656.
650 4 $a Biology, Microbiology. $3 1017734
650 4 $a Biology, Parasitology. $3 1028974
690 $a 0410
690 $a 0718
710 2 $a State University of New York at Buffalo. $b Microbiology and Immunology. $3 1025245
773 0 $t Dissertation Abstracts International $g 71-02B.
790 1 0 $a Williams, Noreen, $e advisor
790 1 0 $a Ruyechan, William $e committee member
790 1 0 $a O'Brian, Mark $e committee member
790 1 0 $a Murphy, Timothy $e committee member
790 $a 0656
791 $a Ph.D.
792 $a 2010
856 4 0 $u http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3391043