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The smoothened receptor in cancer an...

Ruat, Martial.

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The smoothened receptor in cancer and regenerative medicine

Record Type:	Language materials, printed : Monograph/item
Title/Author:	The smoothened receptor in cancer and regenerative medicine/ edited by Martial Ruat.
other author:	Ruat, Martial.
Published:	Cham :Springer International Publishing : : 2015.,
Description:	vii, 210 p. :ill., digital ;24 cm.
[NT 15003449]:	Canonical and non canonical Hedgehog signaling pathways, coupling to G-proteins -- Pharmacochemistry of the Smoothened receptor: Agonists, antagonists, allosteric modulators -- Receptor modifications in Hedgehog regulation -- Smoothened, stem cell maintenance and brain diseases -- Medulloblastoma, pediatric brain tumors and Smoothened blockade -- Role of Smoothened and Hedgehog signaling in angiogenesis, neovascularization -- Implications in stem cell maintenance -- Comparison of the crystal structure of Smoothened to known GPCRs structure.
Contained By:	Springer eBooks
Subject:	Regenerative medicine - Methods. -
Online resource:	http://dx.doi.org/10.1007/978-3-319-19755-5
ISBN:	9783319197555 (electronic bk.)

The smoothened receptor in cancer and regenerative medicine
The smoothened receptor in cancer and regenerative medicine[electronic resource] /edited by Martial Ruat. - Cham :Springer International Publishing :2015. - vii, 210 p. :ill., digital ;24 cm. - Topics in medicinal chemistry,161862-2461 ;. - Topics in medicinal chemistry ;8.

Canonical and non canonical Hedgehog signaling pathways, coupling to G-proteins -- Pharmacochemistry of the Smoothened receptor: Agonists, antagonists, allosteric modulators -- Receptor modifications in Hedgehog regulation -- Smoothened, stem cell maintenance and brain diseases -- Medulloblastoma, pediatric brain tumors and Smoothened blockade -- Role of Smoothened and Hedgehog signaling in angiogenesis, neovascularization -- Implications in stem cell maintenance -- Comparison of the crystal structure of Smoothened to known GPCRs structure.

Medicinal chemistry is both science and art. The science of medicinal chemistry offers mankind one of its best hopes for improving the quality of life. The art of medicinal chemistry continues to challenge its practitioners with the need for both intuition and experience to discover new drugs. Hence sharing the experience of drug research is uniquely beneficial to the field of medicinal chemistry. Drug research requires interdisciplinary team-work at the interface between chemistry, biology and medicine. Therefore, the topic-related series topics in medicinal chemistry covers all relevant aspects of drug research, e.g. pathobiochemistry of diseases, identification and validation of (emerging) drug targets, structural biology, drugability of targets, drug design approaches, chemogenomics, synthetic chemistry including combinatorial methods, bioorganic chemistry, natural compounds, high-throughput screening, pharmacological in vitro and in vivo investigations, drug-receptor interactions on the molecular level, structure-activity relationships, drug absorption, distribution, metabolism, elimination, toxicology and pharmacogenomics. In general, special volumes are edited by well known guest editors.

ISBN: 9783319197555 (electronic bk.)

Standard No.: 10.1007/978-3-319-19755-5doiSubjects--Topical Terms:

2156338
Regenerative medicine
--Methods.

LC Class. No.: RM300

Dewey Class. No.: 615.1

The smoothened receptor in cancer and regenerative medicine
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520 $a Medicinal chemistry is both science and art. The science of medicinal chemistry offers mankind one of its best hopes for improving the quality of life. The art of medicinal chemistry continues to challenge its practitioners with the need for both intuition and experience to discover new drugs. Hence sharing the experience of drug research is uniquely beneficial to the field of medicinal chemistry. Drug research requires interdisciplinary team-work at the interface between chemistry, biology and medicine. Therefore, the topic-related series topics in medicinal chemistry covers all relevant aspects of drug research, e.g. pathobiochemistry of diseases, identification and validation of (emerging) drug targets, structural biology, drugability of targets, drug design approaches, chemogenomics, synthetic chemistry including combinatorial methods, bioorganic chemistry, natural compounds, high-throughput screening, pharmacological in vitro and in vivo investigations, drug-receptor interactions on the molecular level, structure-activity relationships, drug absorption, distribution, metabolism, elimination, toxicology and pharmacogenomics. In general, special volumes are edited by well known guest editors.
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