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Computational toxicology : = methods...

Nicolotti, Orazio,

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Computational toxicology : = methods and protocols /

Record Type:	Language materials, printed : Monograph/item
Title/Author:	Computational toxicology :/ edited by Orazio Nicolotti.
Reminder of title:	methods and protocols /
remainder title:	Computational toxicology :
other author:	Nicolotti, Orazio,
Published:	New York, NY :Humana Press, : c2025. ,
Description:	xiv, 445 p. :ill. (some col.) ;27 cm.
[NT 15003449]:	QSAR : using the past to study the present -- Molecular similarity in predictive toxicology with a focus on the q-RASAR technique -- Weight of evidence : criteria and applications -- Integration of QSAR and NAM in the read across process for an effective and relevant toxicological assessment -- Automated workflows for data curation and machine learning to develop quantitative structure-activity relationships -- Applicability domain for trustable predictions -- The potential of molecular docking for predictive toxicology -- Computational toxicology methods in chemical library design and high-throughput screening hit validation -- Toxicity potential of nutraceuticals -- Development, use and validation of (Q)SARs for predicting genotoxicity and carcinogenicity : experiences from Italian National Institute of Health activities -- Adverse outcome pathways mechanistically describing hepatotoxicity -- Machine learning in early prediction of metabolism of drugs -- In vitro cell-based MTT and crystal violet assays for drug toxicity screening -- Recent advances in nanodrug delivery systems production, efficacy, safety and toxicity -- Investigating the benefit-risk profile of drugs: from spontaneous reporting systems to real-world data for pharmacovigilance -- MolPredictX : a pioneer mobile app version for online biological activity predictions by machine learning models -- TIRESIA and TISBE, explainable artificial intelligence-based web platforms for the transparent assessment of the developmental toxicity of chemicals and drugs -- PFAS-biomolecule interactions: case study using Asclepios nodes and automated workflows in KNIME for drug discovery and toxicology.
Subject:	Toxicology - Laboratory manuals. - Data processing -
ISBN:	9781071640029

Computational toxicology : = methods and protocols /
Computational toxicology :methods and protocols /Computational toxicology :methods & protocols edited by Orazio Nicolotti. - 2nd ed. - New York, NY :Humana Press,c2025. - xiv, 445 p. :ill. (some col.) ;27 cm. - Methods in molecular biology,2834 1064-3745 ;. - Methods in molecular biology ;2834..

Includes bibliographical references and index.

QSAR : using the past to study the present -- Molecular similarity in predictive toxicology with a focus on the q-RASAR technique -- Weight of evidence : criteria and applications -- Integration of QSAR and NAM in the read across process for an effective and relevant toxicological assessment -- Automated workflows for data curation and machine learning to develop quantitative structure-activity relationships -- Applicability domain for trustable predictions -- The potential of molecular docking for predictive toxicology -- Computational toxicology methods in chemical library design and high-throughput screening hit validation -- Toxicity potential of nutraceuticals -- Development, use and validation of (Q)SARs for predicting genotoxicity and carcinogenicity : experiences from Italian National Institute of Health activities -- Adverse outcome pathways mechanistically describing hepatotoxicity -- Machine learning in early prediction of metabolism of drugs -- In vitro cell-based MTT and crystal violet assays for drug toxicity screening -- Recent advances in nanodrug delivery systems production, efficacy, safety and toxicity -- Investigating the benefit-risk profile of drugs: from spontaneous reporting systems to real-world data for pharmacovigilance -- MolPredictX : a pioneer mobile app version for online biological activity predictions by machine learning models -- TIRESIA and TISBE, explainable artificial intelligence-based web platforms for the transparent assessment of the developmental toxicity of chemicals and drugs -- PFAS-biomolecule interactions: case study using Asclepios nodes and automated workflows in KNIME for drug discovery and toxicology.

This second eidtion explores new and updated techniques used to understand solid target-specific models in computational toxicology. Chapters are divided into four sections, detailing molecular descriptors, QSAR and read-across, molecular and data modeling techniques, computational toxicology in drug discovery, molecular fingerprints, AI techniques, and safe drug design. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and key tips on troubleshooting and avoiding known pitfalls. Authoritative and cutting-edge, Computational Toxicology: Methods and Protocols, Second Editon aims to ensure successful results in the further study of this vital field.

ISBN: 9781071640029EUR179.99Subjects--Topical Terms:

3812598
Toxicology
--Data processing--Laboratory manuals.

LC Class. No.: RA1216

Dewey Class. No.: 615.900285

Computational toxicology : = methods and protocols /
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020 $a 107164002X $q (hbk.)
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035 $a (OCoLC)on1458822374
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245 0 0 $a Computational toxicology : $b methods and protocols / $c edited by Orazio Nicolotti.
246 3 # $a Computational toxicology : $b methods & protocols
250 $a 2nd ed.
260 # $a New York, NY : $b Humana Press, $c c2025.
300 $a xiv, 445 p. : $b ill. (some col.) ; $c 27 cm.
490 0 1 $a Methods in molecular biology, $x 1064-3745 ; $v 2834
504 $a Includes bibliographical references and index.
505 0 # $a QSAR : using the past to study the present -- Molecular similarity in predictive toxicology with a focus on the q-RASAR technique -- Weight of evidence : criteria and applications -- Integration of QSAR and NAM in the read across process for an effective and relevant toxicological assessment -- Automated workflows for data curation and machine learning to develop quantitative structure-activity relationships -- Applicability domain for trustable predictions -- The potential of molecular docking for predictive toxicology -- Computational toxicology methods in chemical library design and high-throughput screening hit validation -- Toxicity potential of nutraceuticals -- Development, use and validation of (Q)SARs for predicting genotoxicity and carcinogenicity : experiences from Italian National Institute of Health activities -- Adverse outcome pathways mechanistically describing hepatotoxicity -- Machine learning in early prediction of metabolism of drugs -- In vitro cell-based MTT and crystal violet assays for drug toxicity screening -- Recent advances in nanodrug delivery systems production, efficacy, safety and toxicity -- Investigating the benefit-risk profile of drugs: from spontaneous reporting systems to real-world data for pharmacovigilance -- MolPredictX : a pioneer mobile app version for online biological activity predictions by machine learning models -- TIRESIA and TISBE, explainable artificial intelligence-based web platforms for the transparent assessment of the developmental toxicity of chemicals and drugs -- PFAS-biomolecule interactions: case study using Asclepios nodes and automated workflows in KNIME for drug discovery and toxicology.
520 # $a This second eidtion explores new and updated techniques used to understand solid target-specific models in computational toxicology. Chapters are divided into four sections, detailing molecular descriptors, QSAR and read-across, molecular and data modeling techniques, computational toxicology in drug discovery, molecular fingerprints, AI techniques, and safe drug design. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and key tips on troubleshooting and avoiding known pitfalls. Authoritative and cutting-edge, Computational Toxicology: Methods and Protocols, Second Editon aims to ensure successful results in the further study of this vital field.
650 # 0 $a Toxicology $x Data processing $v Laboratory manuals. $3 3812598
650 # 0 $a QSAR (Biochemistry) $v Laboratory manuals. $3 3812599
700 1 # $a Nicolotti, Orazio, $e editor. $3 3812596
830 0 $a Methods in molecular biology ; $v 2834. $3 3812597