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The effects of R(+)-lipoic and acid ...

Staples, Elizabeth M.

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The effects of R(+)-lipoic and acid supplementation on regulation of human skeletal muscle pyruvate dehydrogenase.

Record Type:	Language materials, printed : Monograph/item
Title/Author:	The effects of R(+)-lipoic and acid supplementation on regulation of human skeletal muscle pyruvate dehydrogenase./
Author:	Staples, Elizabeth M.
Description:	91 p.
Notes:	Source: Masters Abstracts International, Volume: 44-04, page: 1832.
Contained By:	Masters Abstracts International44-04.
Subject:	Biology, Animal Physiology. -
Online resource:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=MR10762
ISBN:	9780494107621

The effects of R(+)-lipoic and acid supplementation on regulation of human skeletal muscle pyruvate dehydrogenase.
Staples, Elizabeth M.

The effects of R(+)-lipoic and acid supplementation on regulation of human skeletal muscle pyruvate dehydrogenase. - 91 p.

Source: Masters Abstracts International, Volume: 44-04, page: 1832.

Thesis (M.Sc.)--Brock University (Canada), 2006.

This thesis investigated whole body glucose disposal and the adaptive changes in skeletal muscle carbohydrate metabolism following 28 d of supplementation with 1000 mg R(+)-lipoic acid in young sedentary males (age, 22.1 +/- 0.67 yr, body mass, 78.7 +/- 10.3 kg, n=9). In certain individuals, lipoic acid decreased the 180-min area under the glucose concentration and insulin concentration curve during an oral glucose tolerance test (OGTT) (n=4). In the same individuals, lipoic acid supplementation decreased pyruvate dehydrogenase kinase activity (PDK) (0.09 +/- 0.024 min-1 vs. 0.137 +/- 0.023 min-1, n=4). The fasting levels of the activated form of pyruvate dehydrogenase (PDHa) were decreased following lipoic acid (0.42 +/- 0.13 mmol·min-1·kg-1 vs. 0.82 +/- 0.32 mmol·min-1·kg-1 , n=4), yet increased to a greater extent during the OGTT (1.21 +/- 0.34 mmol·min-1·kg-1 vs. 0.81 +/- 0.13 mmol·min-1·kg -1, n=4) following lipoic acid supplementation. No changes were demonstrated in the remaining subjects (n=5). It was concluded that improved glucose clearance during an OGTT following lipoic acid supplementation is assisted by increased muscle glucose oxidation through increased PDHa activation and decreased PDK activity in certain individuals.

ISBN: 9780494107621Subjects--Topical Terms:

1017835
Biology, Animal Physiology.

The effects of R(+)-lipoic and acid supplementation on regulation of human skeletal muscle pyruvate dehydrogenase.
LDR:02122nam 2200253 a 45 001 969204
005 20110920
008 110921s2006 eng d
020 $a 9780494107621
035 $a (UMI)AAIMR10762
035 $a AAIMR10762
040 $a UMI $c UMI
100 1 $a Staples, Elizabeth M. $3 1293258
245 1 4 $a The effects of R(+)-lipoic and acid supplementation on regulation of human skeletal muscle pyruvate dehydrogenase.
300 $a 91 p.
500 $a Source: Masters Abstracts International, Volume: 44-04, page: 1832.
502 $a Thesis (M.Sc.)--Brock University (Canada), 2006.
520 $a This thesis investigated whole body glucose disposal and the adaptive changes in skeletal muscle carbohydrate metabolism following 28 d of supplementation with 1000 mg R(+)-lipoic acid in young sedentary males (age, 22.1 +/- 0.67 yr, body mass, 78.7 +/- 10.3 kg, n=9). In certain individuals, lipoic acid decreased the 180-min area under the glucose concentration and insulin concentration curve during an oral glucose tolerance test (OGTT) (n=4). In the same individuals, lipoic acid supplementation decreased pyruvate dehydrogenase kinase activity (PDK) (0.09 +/- 0.024 min-1 vs. 0.137 +/- 0.023 min-1, n=4). The fasting levels of the activated form of pyruvate dehydrogenase (PDHa) were decreased following lipoic acid (0.42 +/- 0.13 mmol·min-1·kg-1 vs. 0.82 +/- 0.32 mmol·min-1·kg-1 , n=4), yet increased to a greater extent during the OGTT (1.21 +/- 0.34 mmol·min-1·kg-1 vs. 0.81 +/- 0.13 mmol·min-1·kg -1, n=4) following lipoic acid supplementation. No changes were demonstrated in the remaining subjects (n=5). It was concluded that improved glucose clearance during an OGTT following lipoic acid supplementation is assisted by increased muscle glucose oxidation through increased PDHa activation and decreased PDK activity in certain individuals.
590 $a School code: 1476.
650 4 $a Biology, Animal Physiology. $3 1017835
650 4 $a Health Sciences, Recreation. $3 1018003
690 $a 0433
690 $a 0575
710 2 0 $a Brock University (Canada). $3 1018667
773 0 $t Masters Abstracts International $g 44-04.
790 $a 1476
791 $a M.Sc.
792 $a 2006
856 4 0 $u http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=MR10762