東華大學圖書館 |

Language: English

Help

回圖書館首頁

手機版館藏查詢

Back to Search results for [ null ]

Switch To: Labeled | MARC Mode | ISBD

Establishment and validation of a ra...

Glazebrook, Mark.

Linked to FindBook

Google Book

Amazon

博客來

Establishment and validation of a rat Achilles tendon overuse exercise model with characterization of histology, biochemistry, biomechanics and collagen crosslinking.

Record Type:	Language materials, printed : Monograph/item
Title/Author:	Establishment and validation of a rat Achilles tendon overuse exercise model with characterization of histology, biochemistry, biomechanics and collagen crosslinking./
Author:	Glazebrook, Mark.
Description:	127 p.
Notes:	Source: Dissertation Abstracts International, Volume: 67-07, Section: B, page: 3693.
Contained By:	Dissertation Abstracts International67-07B.
Subject:	Biophysics, Medical. -
Online resource:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=NR16698
ISBN:	9780494166987

Establishment and validation of a rat Achilles tendon overuse exercise model with characterization of histology, biochemistry, biomechanics and collagen crosslinking.
Glazebrook, Mark.

Establishment and validation of a rat Achilles tendon overuse exercise model with characterization of histology, biochemistry, biomechanics and collagen crosslinking. - 127 p.

Source: Dissertation Abstracts International, Volume: 67-07, Section: B, page: 3693.

Thesis (Ph.D.)--Dalhousie University (Canada), 2006.

Non-insertional disorders of the Achilles tendon cause pain, disability, may predispose to catastrophic rupture, and are increasing in frequency. Currently, the pathobiology of Achilles tendon disease is poorly understood. This thesis seeks to improve the understanding of Achilles tendon disease biology by establishing an animal model for Achilles tendon disease. The animal model is based on an over-exercise uphill treadmill running regime imposed on rats. It has been validated as providing tendon samples with histological characteristics similar to those commonly cited in the literature for human Achilles tendon disease. These include increased cellularity, and more disorganized, more intensely stained collagen fibers. Immunohistochemical staining of the diseased tendons show that the increased cell numbers are principally fibroblasts and/or endothelial cells---not leukocytes. This is suggestive that the underlying biological response is more reparative than inflammatory. Biochemical testing revealed that the tendons had increased levels of glycosaminoglycans but no increase in collagen content. The collagen thermomechanics of the Achilles tendons from running rats demonstrated decreased intrahelical crosslinking that was similar to the features observed in maturing rat tendons. These biochemical changes did not translate into altered biomechanical properties when the tendons were subjected to mechanical testing. In summary, an animal model for Achilles tendon disease has been established that produces rat Achilles tendons with histological characteristics similar to those observed in human Achilles tendon disease. The underlying histology and biochemistry is suggestive that overuse-exercise running in the rat may induce biological repair or remodeling of the Achilles tendon.

ISBN: 9780494166987Subjects--Topical Terms:

1017681
Biophysics, Medical.

Establishment and validation of a rat Achilles tendon overuse exercise model with characterization of histology, biochemistry, biomechanics and collagen crosslinking.
LDR:02720nam 2200265 a 45 001 969166
005 20110920
008 110921s2006 eng d
020 $a 9780494166987
035 $a (UMI)AAINR16698
035 $a AAINR16698
040 $a UMI $c UMI
100 1 $a Glazebrook, Mark. $3 619734
245 1 0 $a Establishment and validation of a rat Achilles tendon overuse exercise model with characterization of histology, biochemistry, biomechanics and collagen crosslinking.
300 $a 127 p.
500 $a Source: Dissertation Abstracts International, Volume: 67-07, Section: B, page: 3693.
502 $a Thesis (Ph.D.)--Dalhousie University (Canada), 2006.
520 $a Non-insertional disorders of the Achilles tendon cause pain, disability, may predispose to catastrophic rupture, and are increasing in frequency. Currently, the pathobiology of Achilles tendon disease is poorly understood. This thesis seeks to improve the understanding of Achilles tendon disease biology by establishing an animal model for Achilles tendon disease. The animal model is based on an over-exercise uphill treadmill running regime imposed on rats. It has been validated as providing tendon samples with histological characteristics similar to those commonly cited in the literature for human Achilles tendon disease. These include increased cellularity, and more disorganized, more intensely stained collagen fibers. Immunohistochemical staining of the diseased tendons show that the increased cell numbers are principally fibroblasts and/or endothelial cells---not leukocytes. This is suggestive that the underlying biological response is more reparative than inflammatory. Biochemical testing revealed that the tendons had increased levels of glycosaminoglycans but no increase in collagen content. The collagen thermomechanics of the Achilles tendons from running rats demonstrated decreased intrahelical crosslinking that was similar to the features observed in maturing rat tendons. These biochemical changes did not translate into altered biomechanical properties when the tendons were subjected to mechanical testing. In summary, an animal model for Achilles tendon disease has been established that produces rat Achilles tendons with histological characteristics similar to those observed in human Achilles tendon disease. The underlying histology and biochemistry is suggestive that overuse-exercise running in the rat may induce biological repair or remodeling of the Achilles tendon.
590 $a School code: 0328.
650 4 $a Biophysics, Medical. $3 1017681
650 4 $a Health Sciences, Medicine and Surgery. $3 1017756
650 4 $a Health Sciences, Recreation. $3 1018003
690 $a 0564
690 $a 0575
690 $a 0760
710 2 0 $a Dalhousie University (Canada). $3 1017625
773 0 $t Dissertation Abstracts International $g 67-07B.
790 $a 0328
791 $a Ph.D.
792 $a 2006
856 4 0 $u http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=NR16698