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The dose-response effects of melaton...

Kenney, James Lawrence.

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The dose-response effects of melatonin ingestion on sustained exercise, thermoregulation, and associated neurobehavioral assessments.

Record Type:	Language materials, printed : Monograph/item
Title/Author:	The dose-response effects of melatonin ingestion on sustained exercise, thermoregulation, and associated neurobehavioral assessments./
Author:	Kenney, James Lawrence.
Description:	92 p.
Notes:	Adviser: Roger A. Fielding.
Contained By:	Dissertation Abstracts International67-09B.
Subject:	Biology, Animal Physiology. -
Online resource:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3232900
ISBN:	9780542868542

The dose-response effects of melatonin ingestion on sustained exercise, thermoregulation, and associated neurobehavioral assessments.
Kenney, James Lawrence.

The dose-response effects of melatonin ingestion on sustained exercise, thermoregulation, and associated neurobehavioral assessments. - 92 p.

Adviser: Roger A. Fielding.

Thesis (Ph.D.)--Boston University, 2006.

Background. Melatonin when administered in pharmacological doses has antioxidant properties that may impact the physiological response to exercise. However, of particular concern, is that melatonin-induced soporific effects might sufficiently compromise cognitive and physical performance to offset any physiological advantage. Objectives. To evaluate: (1) if there is a melatonin dose in which its pharmacological properties may be expressed, without altering the perception of, or the ability to, exercise; and (2) whether melatonin modulates the central thermoregulatory set-point. Methods. Ten human subjects participated in four definitive experiments where they ingested 5, 50, or 250 mg of melatonin or a placebo. Each definitive experiment consisted of two 30-min treadmill running bouts at 67% and 77% of individual maximal oxygen uptake, respectively. During each exercise bout, respiratory gas exchange, ratings of perceived exertion, heart rate, upper arm sweating rate, and esophageal and skin temperatures were recorded. Results. For all doses, melatonin ingestion resulted in correspondingly increased plasma concentrations that did not impact the subjects' perception of, or ability to, exercise. Melatonin ingestion did not impact cardiopulmonary or metabolic responses to exercise. Melatonin had no effect on resting body temperatures or the magnitude of core body temperature increase during exercise, implying little or no effect on the set-point temperature. The 5- and 50-mg melatonin doses increased the sweat-rate response during exercise, but had no effect the threshold for the onset of sweating or the physiological strain during exercise. Conclusions. These findings demonstrate that pharmacological concentrations of melatonin in doses ranging from 5- to 250 mg do not impact the perception of, or the ability to sustain two 30-min bouts of strenuous exercise. Melatonin can increase the local sweating rate out of proportion to relative increases in core body temperature; and the typical soporific properties of melatonin that increase sleepiness, fatigue, and reaction-response time were antagonized by the residual alerting effects of exercise.

ISBN: 9780542868542Subjects--Topical Terms:

1017835
Biology, Animal Physiology.

The dose-response effects of melatonin ingestion on sustained exercise, thermoregulation, and associated neurobehavioral assessments.
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005 20110901
008 110901s2006 eng d
020 $a 9780542868542
035 $a (UMI)AAI3232900
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040 $a UMI $c UMI
100 1 $a Kenney, James Lawrence. $3 1287134
245 1 4 $a The dose-response effects of melatonin ingestion on sustained exercise, thermoregulation, and associated neurobehavioral assessments.
300 $a 92 p.
500 $a Adviser: Roger A. Fielding.
500 $a Source: Dissertation Abstracts International, Volume: 67-09, Section: B, page: 4788.
502 $a Thesis (Ph.D.)--Boston University, 2006.
520 $a Background. Melatonin when administered in pharmacological doses has antioxidant properties that may impact the physiological response to exercise. However, of particular concern, is that melatonin-induced soporific effects might sufficiently compromise cognitive and physical performance to offset any physiological advantage. Objectives. To evaluate: (1) if there is a melatonin dose in which its pharmacological properties may be expressed, without altering the perception of, or the ability to, exercise; and (2) whether melatonin modulates the central thermoregulatory set-point. Methods. Ten human subjects participated in four definitive experiments where they ingested 5, 50, or 250 mg of melatonin or a placebo. Each definitive experiment consisted of two 30-min treadmill running bouts at 67% and 77% of individual maximal oxygen uptake, respectively. During each exercise bout, respiratory gas exchange, ratings of perceived exertion, heart rate, upper arm sweating rate, and esophageal and skin temperatures were recorded. Results. For all doses, melatonin ingestion resulted in correspondingly increased plasma concentrations that did not impact the subjects' perception of, or ability to, exercise. Melatonin ingestion did not impact cardiopulmonary or metabolic responses to exercise. Melatonin had no effect on resting body temperatures or the magnitude of core body temperature increase during exercise, implying little or no effect on the set-point temperature. The 5- and 50-mg melatonin doses increased the sweat-rate response during exercise, but had no effect the threshold for the onset of sweating or the physiological strain during exercise. Conclusions. These findings demonstrate that pharmacological concentrations of melatonin in doses ranging from 5- to 250 mg do not impact the perception of, or the ability to sustain two 30-min bouts of strenuous exercise. Melatonin can increase the local sweating rate out of proportion to relative increases in core body temperature; and the typical soporific properties of melatonin that increase sleepiness, fatigue, and reaction-response time were antagonized by the residual alerting effects of exercise.
590 $a School code: 0017.
650 4 $a Biology, Animal Physiology. $3 1017835
650 4 $a Health Sciences, Pharmacology. $3 1017717
650 4 $a Health Sciences, Recreation. $3 1018003
650 4 $a Psychology, Behavioral. $3 1017677
650 4 $a Psychology, Physiological. $3 1017869
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773 0 $t Dissertation Abstracts International $g 67-09B.
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791 $a Ph.D.
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856 4 0 $u http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3232900