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Controlling membrane organization: C...

Cambrea, Lee R.

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Controlling membrane organization: Chemical and spectroscopic properties of lipid bilayers.

Record Type:	Language materials, printed : Monograph/item
Title/Author:	Controlling membrane organization: Chemical and spectroscopic properties of lipid bilayers./
Author:	Cambrea, Lee R.
Description:	171 p.
Notes:	Adviser: Jennifer S. Hovis.
Contained By:	Dissertation Abstracts International68-10B.
Subject:	Chemistry, Analytical. -
Online resource:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3287262
ISBN:	9780549303213

Controlling membrane organization: Chemical and spectroscopic properties of lipid bilayers.
Cambrea, Lee R.

Controlling membrane organization: Chemical and spectroscopic properties of lipid bilayers. - 171 p.

Adviser: Jennifer S. Hovis.

Thesis (Ph.D.)--Purdue University, 2007.

Cells are not at equilibrium; ion concentrations continuously fluctuate and molecules are transported, created, and destroyed leading to the dynamic environment necessary for life. Even the lipid composition of the cell membrane is known to vary throughout the lifetime of the cell; however, the effects of this variation on cellular function are generally unknown. Fluorescence recovery after photobleaching (FRAP), epi-fluorescence microscopy, confocal microscopy, and attenuated total reflection Fourier transform infrared spectroscopy (ATR-FTIR) have been used to examine effect of lipid chemistries, heat, and ionic strength on the properties of supported lipid bilayers. It will be demonstrated that ATR-FTIR spectroscopy can be successfully used to obtain information about the conformation of lipid head groups (e.g. CN+C, PO 2-), the hydration/hydrogen-bonding between and around lipids (e.g. CO, PO2-), and the orientation/conformation of the hydrocarbon chains (e.g. CH2, CH3).

ISBN: 9780549303213Subjects--Topical Terms:

586156
Chemistry, Analytical.

Controlling membrane organization: Chemical and spectroscopic properties of lipid bilayers.
LDR:02274nam 2200277 a 45 001 962791
005 20110830
008 110831s2007 ||||||||||||||||| ||eng d
020 $a 9780549303213
035 $a (UMI)AAI3287262
035 $a AAI3287262
040 $a UMI $c UMI
100 1 $a Cambrea, Lee R. $3 1285851
245 1 0 $a Controlling membrane organization: Chemical and spectroscopic properties of lipid bilayers.
300 $a 171 p.
500 $a Adviser: Jennifer S. Hovis.
500 $a Source: Dissertation Abstracts International, Volume: 68-10, Section: B, page: 6632.
502 $a Thesis (Ph.D.)--Purdue University, 2007.
520 $a Cells are not at equilibrium; ion concentrations continuously fluctuate and molecules are transported, created, and destroyed leading to the dynamic environment necessary for life. Even the lipid composition of the cell membrane is known to vary throughout the lifetime of the cell; however, the effects of this variation on cellular function are generally unknown. Fluorescence recovery after photobleaching (FRAP), epi-fluorescence microscopy, confocal microscopy, and attenuated total reflection Fourier transform infrared spectroscopy (ATR-FTIR) have been used to examine effect of lipid chemistries, heat, and ionic strength on the properties of supported lipid bilayers. It will be demonstrated that ATR-FTIR spectroscopy can be successfully used to obtain information about the conformation of lipid head groups (e.g. CN+C, PO 2-), the hydration/hydrogen-bonding between and around lipids (e.g. CO, PO2-), and the orientation/conformation of the hydrocarbon chains (e.g. CH2, CH3).
520 $a Results will also be presented demonstrating that it is possible to create both reversible and irreversible changes to the membrane organization and curvature through use of a biologically relevant process, fluctuations in the bulk ionic strength. Also demonstrated is the ability to control the fluidity of phase separation within a binary lipid mixture by alterations to the lipid compositions.
590 $a School code: 0183.
650 4 $a Chemistry, Analytical. $3 586156
690 $a 0486
710 2 $a Purdue University. $b Chemistry. $3 1019176
773 0 $t Dissertation Abstracts International $g 68-10B.
790 $a 0183
790 1 0 $a Hovis, Jennifer S., $e advisor
791 $a Ph.D.
792 $a 2007
856 4 0 $u http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3287262