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Nuclear functions of an inositol pol...

Odom, Audrey Ragan.

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Nuclear functions of an inositol polyphosphate kinase pathway.

Record Type:	Language materials, printed : Monograph/item
Title/Author:	Nuclear functions of an inositol polyphosphate kinase pathway./
Author:	Odom, Audrey Ragan.
Description:	214 p.
Notes:	Source: Dissertation Abstracts International, Volume: 63-09, Section: B, page: 4034.
Contained By:	Dissertation Abstracts International63-09B.
Subject:	Biology, Cell. -
Online resource:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3063197
ISBN:	0493819428

Nuclear functions of an inositol polyphosphate kinase pathway.
Odom, Audrey Ragan.

Nuclear functions of an inositol polyphosphate kinase pathway. - 214 p.

Source: Dissertation Abstracts International, Volume: 63-09, Section: B, page: 4034.

Thesis (Ph.D.)--Duke University, 2002.

Phosphoinositide (PI) signaling is pivotal to cellular processes ranging from proliferation and differentiation to apoptosis. Classically, activation of phospholipase C releases the second messenger IP3 to mediate intracellular calcium release. IP3 is also a metabolic precursor to higher phosphorylated inositol phosphates, such as IP4, IP5, and IP6, many of which have uncharacterized cellular functions. This work defines the metabolic pathway for IP6 synthesis through genetic and biochemical studies in the budding yeast, <italic>Saccharomyces cerevisiae</italic>. The action of phospholipase C in yeast produces IP 3, which is then sequentially phosphorylated by two inositol polyphosphate kinases to produce IP4, IP5, and ultimately IP 6. Genetic interactions with phospholipase C, these two inositol phosphate kinases, and the essential mRNA export factor Gle1 have established a role for IP6 production in efficient nucleocytoplasmic transport of messenger RNA.

ISBN: 0493819428Subjects--Topical Terms:

1017686
Biology, Cell.

Nuclear functions of an inositol polyphosphate kinase pathway.
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100 1 $a Odom, Audrey Ragan. $3 1251348
245 1 0 $a Nuclear functions of an inositol polyphosphate kinase pathway.
300 $a 214 p.
500 $a Source: Dissertation Abstracts International, Volume: 63-09, Section: B, page: 4034.
500 $a Supervisor: John D. York.
502 $a Thesis (Ph.D.)--Duke University, 2002.
520 $a Phosphoinositide (PI) signaling is pivotal to cellular processes ranging from proliferation and differentiation to apoptosis. Classically, activation of phospholipase C releases the second messenger IP3 to mediate intracellular calcium release. IP3 is also a metabolic precursor to higher phosphorylated inositol phosphates, such as IP4, IP5, and IP6, many of which have uncharacterized cellular functions. This work defines the metabolic pathway for IP6 synthesis through genetic and biochemical studies in the budding yeast, <italic>Saccharomyces cerevisiae</italic>. The action of phospholipase C in yeast produces IP 3, which is then sequentially phosphorylated by two inositol polyphosphate kinases to produce IP4, IP5, and ultimately IP 6. Genetic interactions with phospholipase C, these two inositol phosphate kinases, and the essential mRNA export factor Gle1 have established a role for IP6 production in efficient nucleocytoplasmic transport of messenger RNA.
520 $a We have also found that the dual-specificity IP3/IP4 kinase of this pathway, Ipk2, is identical to the transcriptional regulator Arg82 and is localized to the nucleus of the cell. Ipk2 protein, but not its kinase activity or inositol phosphate products, is important for assembly of and transcriptional repression through a particular transcriptional complex. Importantly, mutations that impair IP4/IP5 production do specifically impair activation of this assembled complex, indicating a role for IP4/IP5 production in transcriptional regulation. Genomic expression analysis in cells that fail to produce IP4 or IP5 indicates other targets for this newly appreciated paradigm of inositol phosphate-regulated gene expression.
590 $a School code: 0066.
650 4 $a Biology, Cell. $3 1017686
650 4 $a Biology, Genetics. $3 1017730
650 4 $a Biology, Molecular. $3 1017719
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710 2 0 $a Duke University. $3 569686
773 0 $t Dissertation Abstracts International $g 63-09B.
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791 $a Ph.D.
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