東華大學圖書館 |

Language: English

Help

回圖書館首頁

手機版館藏查詢

Back to Search results for [ null ]

Switch To: Labeled | MARC Mode | ISBD

Stress, cytokines, and neural plasti...

Yale University.

Linked to FindBook

Google Book

Amazon

博客來

Stress, cytokines, and neural plasticity in depression: IL-1beta is an essential mediator of the anti-neurogenic and anhedonic effects of stress.

Record Type:	Language materials, printed : Monograph/item
Title/Author:	Stress, cytokines, and neural plasticity in depression: IL-1beta is an essential mediator of the anti-neurogenic and anhedonic effects of stress./
Author:	Koo, Ja Wook.
Description:	162 p.
Notes:	Adviser: Ronald S. Duman.
Contained By:	Dissertation Abstracts International69-05B.
Subject:	Biology, Neuroscience. -
Online resource:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3317146
ISBN:	9780549658900

Stress, cytokines, and neural plasticity in depression: IL-1beta is an essential mediator of the anti-neurogenic and anhedonic effects of stress.
Koo, Ja Wook.

Stress, cytokines, and neural plasticity in depression: IL-1beta is an essential mediator of the anti-neurogenic and anhedonic effects of stress. - 162 p.

Adviser: Ronald S. Duman.

Thesis (Ph.D.)--Yale University, 2008.

Depression is a very serious mental illness that affects nearly 20 percent of the US population and results in enormous personal suffering and socioeconomic burden. A major contributing factor to depression is uncontrollable stress, which can precipitate or exacerbate depression. Stress-induced reduction of hippocampal neurogenesis has been extensively investigated, based on the idea that the therapeutic effects of antidepressants involve a reversal of the stress-induced hippocampal impairment. However, the mechanisms underlying the anti-neurogenic and behavioral actions of stress to pathophysiology of depression remain ill defined. One possibility is interleukin (IL)-1beta, which is a pro-inflammatory cytokine that has been implicated as a mediator of stress and a causative factor in emotional disorders, including depression and anxiety. In chapter 2, I demonstrate that IL-1beta underlies the anti-neurogenic effects of stress. Both acute and chronic stress suppressed hippocampal neurogenesis, of which the down-regulation was blocked by pre-administration of IL-1 receptor antagonist (Ra). The role of IL-1beta in the anti-neurogenic actions of acute and chronic stress was further confirmed in mice with a null mutation of the only effective IL-1beta receptor, IL-1RI. In chapter 3, I show a role of IL-1beta in the anhedonic effects of chronic unpredictable stress (CUS). The pharmacological and genetic inactivation of IL-1RI blocked the anhedonic behavior resulting from CUS. Furthermore, I charaterized the role of IL-1beta in anxiety and fear models with IL-1RI null mice, which revealed that the IL-1beta/IL-1RI system may directly influence anxiety and fear memory formation. In chapter 4, I explore the mechanisms underlying the anti-proliferative actions of IL-1beta using cultured rat adult hippocampal progenitors. I found that that IL-1beta and IL-1Ra act on cell proliferation via the IL-1R1 expressed on the neural progenitors. The anti-proliferative action of IL-1beta occurs through regulating the cell cycle, in particular, the expression of cyclin D1 and through activation of the nuclear factor-kappaB pathway in adult hippocampal progenitors. Taken together, my findings demonstrate that IL-1beta is a key mediator of stress on adult hippocampal neurogenesis and depression-related behaviors.

ISBN: 9780549658900Subjects--Topical Terms:

1017680
Biology, Neuroscience.

Stress, cytokines, and neural plasticity in depression: IL-1beta is an essential mediator of the anti-neurogenic and anhedonic effects of stress.
LDR:03292nam 2200289 a 45 001 855207
005 20100708
008 100708s2008 ||||||||||||||||| ||eng d
020 $a 9780549658900
035 $a (UMI)AAI3317146
035 $a AAI3317146
040 $a UMI $c UMI
100 1 $a Koo, Ja Wook. $3 1021752
245 1 0 $a Stress, cytokines, and neural plasticity in depression: IL-1beta is an essential mediator of the anti-neurogenic and anhedonic effects of stress.
300 $a 162 p.
500 $a Adviser: Ronald S. Duman.
500 $a Source: Dissertation Abstracts International, Volume: 69-05, Section: B, page: 2817.
502 $a Thesis (Ph.D.)--Yale University, 2008.
520 $a Depression is a very serious mental illness that affects nearly 20 percent of the US population and results in enormous personal suffering and socioeconomic burden. A major contributing factor to depression is uncontrollable stress, which can precipitate or exacerbate depression. Stress-induced reduction of hippocampal neurogenesis has been extensively investigated, based on the idea that the therapeutic effects of antidepressants involve a reversal of the stress-induced hippocampal impairment. However, the mechanisms underlying the anti-neurogenic and behavioral actions of stress to pathophysiology of depression remain ill defined. One possibility is interleukin (IL)-1beta, which is a pro-inflammatory cytokine that has been implicated as a mediator of stress and a causative factor in emotional disorders, including depression and anxiety. In chapter 2, I demonstrate that IL-1beta underlies the anti-neurogenic effects of stress. Both acute and chronic stress suppressed hippocampal neurogenesis, of which the down-regulation was blocked by pre-administration of IL-1 receptor antagonist (Ra). The role of IL-1beta in the anti-neurogenic actions of acute and chronic stress was further confirmed in mice with a null mutation of the only effective IL-1beta receptor, IL-1RI. In chapter 3, I show a role of IL-1beta in the anhedonic effects of chronic unpredictable stress (CUS). The pharmacological and genetic inactivation of IL-1RI blocked the anhedonic behavior resulting from CUS. Furthermore, I charaterized the role of IL-1beta in anxiety and fear models with IL-1RI null mice, which revealed that the IL-1beta/IL-1RI system may directly influence anxiety and fear memory formation. In chapter 4, I explore the mechanisms underlying the anti-proliferative actions of IL-1beta using cultured rat adult hippocampal progenitors. I found that that IL-1beta and IL-1Ra act on cell proliferation via the IL-1R1 expressed on the neural progenitors. The anti-proliferative action of IL-1beta occurs through regulating the cell cycle, in particular, the expression of cyclin D1 and through activation of the nuclear factor-kappaB pathway in adult hippocampal progenitors. Taken together, my findings demonstrate that IL-1beta is a key mediator of stress on adult hippocampal neurogenesis and depression-related behaviors.
590 $a School code: 0265.
650 4 $a Biology, Neuroscience. $3 1017680
650 4 $a Psychology, Physiological. $3 1017869
650 4 $a Psychology, Psychobiology. $3 1017821
690 $a 0317
690 $a 0349
690 $a 0989
710 2 $a Yale University. $3 515640
773 0 $t Dissertation Abstracts International $g 69-05B.
790 $a 0265
790 1 0 $a Duman, Ronald S., $e advisor
791 $a Ph.D.
792 $a 2008
856 4 0 $u http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3317146