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Assessment of Salivary Flow Patterns...

Alsunni, Mouna Abdulshaheed,

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Assessment of Salivary Flow Patterns in Sjogren's Disease (SjD) /

紀錄類型:	書目-電子資源 : Monograph/item
正題名/作者:	Assessment of Salivary Flow Patterns in Sjogren's Disease (SjD) // Mouna Abdulshaheed Alsunni.
作者:	Alsunni, Mouna Abdulshaheed,
面頁冊數:	1 electronic resource (55 pages)
附註:	Source: Masters Abstracts International, Volume: 86-05.
Contained By:	Masters Abstracts International86-05.
標題:	Dentistry. -
電子資源:	https://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=31633794
ISBN:	9798342744713

Assessment of Salivary Flow Patterns in Sjogren's Disease (SjD) /
Alsunni, Mouna Abdulshaheed,

Assessment of Salivary Flow Patterns in Sjogren's Disease (SjD) /Mouna Abdulshaheed Alsunni. - 1 electronic resource (55 pages)

Source: Masters Abstracts International, Volume: 86-05.

Aim and Hypothesis: Salivary flow follows a circadian pattern and is influenced by clock genes, which also regulate Aquaporins (AQPs), water channels responsible for salivary flow regulation in salivary glands. A deficiency in AQP5 in mouse salivary glands disrupted this pattern. We hypothesized that patients with Sjogren's Disease (SjD) do not exhibit the same circadian salivary flow pattern as healthy controls. The study compared salivary flow patterns in healthy individuals and SjD patients. To do this, we assessed stimulated whole saliva (SWS) and unstimulated whole saliva (UWS) patterns in SjD subjects compared with healthy controls.Methods: Thirteen subjects per group were required to achieve 80% power. SjD subjects met the ACR/EULAR2016 criteria. During the first visit, participants provided consent. They received instructions for saliva collection at home at two time points (5 AM and 10 AM) for unstimulated whole saliva (UWS, 5 minutes) and stimulated whole saliva (SWS, 2 minutes), with a third sample collected on-site at 3 PM. Friedman's test compared salivary flow within each group across time points, while the Mann-Whitney U test compared salivary flow between groups. Generalized linear mixed models assessed group-time point interactions. Significance was set at α=0.05.Results: The study analyzed 13 healthy controls (10 female, 3 male, mean age 48.9 ± 10.7 years) and 13 SjD subjects (all female, mean age 65.3 ± 8.4 years). In SjD subjects, SWS 0.84 ± 0.83 mL/min, 1.08 ± 1.13 mL/min, and 1.00 ± 1.12 mL/min (p = 0.037) respectively. UWS ranged from 0.17 ± 0.21 mL/min at 5 AM to 0.24 ± 0.22 mL/min at 3 PM (p=0.46). No significant differences in control SWS; p = 0.527, with respective means of 2.80 ± 1.41 mL/min, 3.25 ± 1.81 mL/min, and 2.70 ± 1.42 mL/min. similar results were found in UWS: 1.03 ± 1.24 mL/min at 5 AM, 1.16 ± 1.34 mL/min at 10 AM, and 1.07 ± 1.29 mL/min at 3 PM (p = 0.527). SjD subjectsivhad significantly lower UWS and SWS rates than healthy controls (p0.05).Conclusion: The data do not support the hypothesis that SjD subjects have an altered salivary flow pattern compared to healthy controls. Neither SWS nor UWS exhibited a clear circadian pattern in healthy individuals, suggesting a need for further research into circadian influences on salivary flow in the healthy population.

English

ISBN: 9798342744713Subjects--Topical Terms:

828971
Dentistry.
Subjects--Index Terms:

Circadian pattern

Assessment of Salivary Flow Patterns in Sjogren's Disease (SjD) /
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520 $a Aim and Hypothesis: Salivary flow follows a circadian pattern and is influenced by clock genes, which also regulate Aquaporins (AQPs), water channels responsible for salivary flow regulation in salivary glands. A deficiency in AQP5 in mouse salivary glands disrupted this pattern. We hypothesized that patients with Sjogren's Disease (SjD) do not exhibit the same circadian salivary flow pattern as healthy controls. The study compared salivary flow patterns in healthy individuals and SjD patients. To do this, we assessed stimulated whole saliva (SWS) and unstimulated whole saliva (UWS) patterns in SjD subjects compared with healthy controls.Methods: Thirteen subjects per group were required to achieve 80% power. SjD subjects met the ACR/EULAR2016 criteria. During the first visit, participants provided consent. They received instructions for saliva collection at home at two time points (5 AM and 10 AM) for unstimulated whole saliva (UWS, 5 minutes) and stimulated whole saliva (SWS, 2 minutes), with a third sample collected on-site at 3 PM. Friedman's test compared salivary flow within each group across time points, while the Mann-Whitney U test compared salivary flow between groups. Generalized linear mixed models assessed group-time point interactions. Significance was set at α=0.05.Results: The study analyzed 13 healthy controls (10 female, 3 male, mean age 48.9 ± 10.7 years) and 13 SjD subjects (all female, mean age 65.3 ± 8.4 years). In SjD subjects, SWS 0.84 ± 0.83 mL/min, 1.08 ± 1.13 mL/min, and 1.00 ± 1.12 mL/min (p = 0.037) respectively. UWS ranged from 0.17 ± 0.21 mL/min at 5 AM to 0.24 ± 0.22 mL/min at 3 PM (p=0.46). No significant differences in control SWS; p = 0.527, with respective means of 2.80 ± 1.41 mL/min, 3.25 ± 1.81 mL/min, and 2.70 ± 1.42 mL/min. similar results were found in UWS: 1.03 ± 1.24 mL/min at 5 AM, 1.16 ± 1.34 mL/min at 10 AM, and 1.07 ± 1.29 mL/min at 3 PM (p = 0.527). SjD subjectsivhad significantly lower UWS and SWS rates than healthy controls (p0.05).Conclusion: The data do not support the hypothesis that SjD subjects have an altered salivary flow pattern compared to healthy controls. Neither SWS nor UWS exhibited a clear circadian pattern in healthy individuals, suggesting a need for further research into circadian influences on salivary flow in the healthy population.
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