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Molecular Basis of Plasticity of Por...

Rexhepaj, Megi,

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Molecular Basis of Plasticity of Porcine Delta Coronavirus (PDCoV) & Development of Countermeasures Against Infection /

紀錄類型:	書目-電子資源 : Monograph/item
正題名/作者:	Molecular Basis of Plasticity of Porcine Delta Coronavirus (PDCoV) & Development of Countermeasures Against Infection // Megi Rexhepaj.
作者:	Rexhepaj, Megi,
面頁冊數:	1 electronic resource (85 pages)
附註:	Source: Dissertations Abstracts International, Volume: 86-03, Section: B.
Contained By:	Dissertations Abstracts International86-03B.
標題:	Biochemistry. -
電子資源:	https://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=31557634
ISBN:	9798384098867

Molecular Basis of Plasticity of Porcine Delta Coronavirus (PDCoV) & Development of Countermeasures Against Infection /
Rexhepaj, Megi,

Molecular Basis of Plasticity of Porcine Delta Coronavirus (PDCoV) & Development of Countermeasures Against Infection /Megi Rexhepaj. - 1 electronic resource (85 pages)

Source: Dissertations Abstracts International, Volume: 86-03, Section: B.

Porcine deltacoronavirus (PDCoV) is an enteric pathogen that infects a broad range of mammal and avian species. Viral entry is achieved through the transmembrane spike (S) glycoprotein, specifically the receptor binding domain (RBD), binding to host receptor aminopeptidase N (APN). The S glycoprotein plays a key role in modulating host and tissue tropism, zoonotic transmission, and pathogenesis. The mechanism by which the S glycoprotein binds to a broad range of host receptors is not understood. Given that the S glycoprotein is the main target of antibodies and that neutralizing antibody titers are a correlate of protection against coronaviruses, the development of vaccines and therapeutics focuses intensively on this glycoprotein target. This research describes the molecular basis of binding of the S glycoprotein to host receptors and identifies the neutralizing epitopes on the S glycoproteins providing the first line of protection for a possible future PDCoV epidemic.

English

ISBN: 9798384098867Subjects--Topical Terms:

518028
Biochemistry.
Subjects--Index Terms:

Porcine deltacoronavirus

Molecular Basis of Plasticity of Porcine Delta Coronavirus (PDCoV) & Development of Countermeasures Against Infection /
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520 $a Porcine deltacoronavirus (PDCoV) is an enteric pathogen that infects a broad range of mammal and avian species. Viral entry is achieved through the transmembrane spike (S) glycoprotein, specifically the receptor binding domain (RBD), binding to host receptor aminopeptidase N (APN). The S glycoprotein plays a key role in modulating host and tissue tropism, zoonotic transmission, and pathogenesis. The mechanism by which the S glycoprotein binds to a broad range of host receptors is not understood. Given that the S glycoprotein is the main target of antibodies and that neutralizing antibody titers are a correlate of protection against coronaviruses, the development of vaccines and therapeutics focuses intensively on this glycoprotein target. This research describes the molecular basis of binding of the S glycoprotein to host receptors and identifies the neutralizing epitopes on the S glycoproteins providing the first line of protection for a possible future PDCoV epidemic.
546 $a English
590 $a School code: 0250
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650 4 $a Molecular biology. $3 517296
650 4 $a Immunology. $3 611031
650 4 $a Virology. $3 642304
653 $a Porcine deltacoronavirus
653 $a Receptor binding domain
653 $a Glycoprotein
653 $a Aminopeptidase N
653 $a Monoclonal antibodies
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856 4 0 $u https://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=31557634