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Properties of Coronavirus Spike Prot...

Addetia, Amin,

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Properties of Coronavirus Spike Proteins and the Antibody Responses Against Them /

紀錄類型:	書目-電子資源 : Monograph/item
正題名/作者:	Properties of Coronavirus Spike Proteins and the Antibody Responses Against Them // Amin Addetia.
作者:	Addetia, Amin,
面頁冊數:	1 electronic resource (263 pages)
附註:	Source: Dissertations Abstracts International, Volume: 85-10, Section: B.
Contained By:	Dissertations Abstracts International85-10B.
標題:	Biochemistry. -
電子資源:	https://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=30988463
ISBN:	9798382211145

Properties of Coronavirus Spike Proteins and the Antibody Responses Against Them /
Addetia, Amin,

Properties of Coronavirus Spike Proteins and the Antibody Responses Against Them /Amin Addetia. - 1 electronic resource (263 pages)

Source: Dissertations Abstracts International, Volume: 85-10, Section: B.

Coronaviruses have a propensity to spillover from zoonotic reservoirs and cause significant morbidity and mortality in the human population. Three coronaviruses emerged and caused significant human outbreaks in recent history: severe acute respiratory syndrome coronavirus (SARS-CoV-1) in 2003, Middle East respiratory syndrome coronavirus (MERS-CoV) in 2012, and severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in 2019. The coronavirus spike protein facilitates viral entry into target cells by engaging the host receptors and fusing the viral and host membrane together. As the primary determinant of viral entry into target cells, the coronavirus spike protein is the target of most vaccines and therapeutics. Antibodies induced by prior infection and vaccination and therapeutics may select for spike protein mutations that evade these antibodies without disrupting the spike protein's ability to engage the host receptor and mediate membrane fusion. In the following dissertation, I detail a unique mechanism of antibody evasion induced by a mutation in the receptor binding domain of the SARS-CoV-2 spike protein. I additionally describe the impact of spike protein mutations observed in the SARS-CoV-2 Omicron variants on receptor engagement, fusogenicity, and evasion from infection- and vaccine-elicited antibodies. I further examine how updated SARS-CoV-2 vaccine formulations shape the humoral immune response. Finally, I detail the contribution of spike protein domains and epitopes to the neutralizing activity of convalescent plasma collected from individuals infected with MERS-CoV. Collectively, my work is informing the development of the next generation of coronavirus vaccines and therapeutics.

English

ISBN: 9798382211145Subjects--Topical Terms:

518028
Biochemistry.
Subjects--Index Terms:

Coronaviruses

Properties of Coronavirus Spike Proteins and the Antibody Responses Against Them /
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653 $a Immune response
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690 $a 0982
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