東華大學圖書館 |

語系: 繁體中文

說明(常見問題)

回圖書館首頁

手機版館藏查詢

登入

回首頁 到查詢結果 [ null ]

切換: 標籤 | MARC模式 | ISBD

Biological Effects of Azadirachta in...

Yusuf, Amirah Folashade,

FindBook

Google Book

Amazon

博客來

Biological Effects of Azadirachta indica and Vernonia amygdalina on AKT Cell Survival and Cell Cycle Pathway in HT-29 Cell Line /

紀錄類型:	書目-電子資源 : Monograph/item
正題名/作者:	Biological Effects of Azadirachta indica and Vernonia amygdalina on AKT Cell Survival and Cell Cycle Pathway in HT-29 Cell Line // Amirah Folashade Yusuf.
作者:	Yusuf, Amirah Folashade,
面頁冊數:	1 electronic resource (143 pages)
附註:	Source: Dissertations Abstracts International, Volume: 86-12, Section: B.
Contained By:	Dissertations Abstracts International86-12B.
標題:	Toxicology. -
電子資源:	https://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=31995387
ISBN:	9798280704039

Biological Effects of Azadirachta indica and Vernonia amygdalina on AKT Cell Survival and Cell Cycle Pathway in HT-29 Cell Line /
Yusuf, Amirah Folashade,

Biological Effects of Azadirachta indica and Vernonia amygdalina on AKT Cell Survival and Cell Cycle Pathway in HT-29 Cell Line /Amirah Folashade Yusuf. - 1 electronic resource (143 pages)

Source: Dissertations Abstracts International, Volume: 86-12, Section: B.

Numerous anticancer research outcomes exist but remain distant from effectively combating cancer occurrence and deaths. The situation requires investigation into alternative cancer treatments through medicinal plants. Cancer research needs advancement through ethnopharmacological and ethnobotanical approaches for developing therapeutic agents which produce fewer adverse effects. Several indications show that extracts from herbal plants demonstrate higher effectiveness. Both Azadirachta indica (A. indica) and Vernonia amygdalina (V. amygdalina) have been identified to have anticancer effects by various mechanisms of action. A. indica demonstrates anticancer activity through mechanisms that inhibit cell proliferation while triggering cell growth arrest, differentiation, and programmed cell death. V. amygdalina mechanisms of action involve reduction of cell viability while triggering apoptosis in cancer cell lines. This research distinguishes itself by investigating the impact of A. indica and V. amygdalina combination therapy on HT-29 cell survival and cell cycle regulatory proteins pathways. The plants Azadirachta indica known as Indian Neem and Vernonia amygdalina called Bitter leaf have earned widespread recognition for their multiple medicinal uses. The neem tree originated in Asia and Africa while the bitter leaf exists only in West Africa.The evaluation of their combined effects on HT-29 cancer cells is crucial to determine the safety and efficacy of these traditional therapeutic plants which have extensive applications across the globe. The regulation of cancer-induced changes in cellular regulatory pathways stands as a vital factor for cancer treatment success. Different analytical approaches were utilized in this research to examine Azadirachta indica and Vernonia amygdalina effects on cancer cells through biochemical interactions, cellular toxicity and therapeutic potential evaluation. Overall, our findings indicate that Azadirachta indica and Vernonia amygdalina modulate the expression of Akt, CCND1, and CDK4, suggesting their involvement in the regulation of cell survival and cell cycle progression in HT-29 cells. These results provide an understanding of the molecular mechanisms underlying Azadirachta indica and Vernonia amygdalina's paradoxical effects and their impact on cellular homeostasis, thus suggesting that A. indica and V. amygdalina possess the potential to be anti-cancer therapeutic agents. A thorough investigation of A. indica and V. amygdalina effects on PKB/AKT and its regulatory proteins downstream remains essential.

English

ISBN: 9798280704039Subjects--Topical Terms:

556884
Toxicology.
Subjects--Index Terms:

Azadirachta indica

Biological Effects of Azadirachta indica and Vernonia amygdalina on AKT Cell Survival and Cell Cycle Pathway in HT-29 Cell Line /
LDR:04156nmm a22004573i 4500 001 2436592
005 20251023121252.5
006 m o d
007 cr|nu||||||||
008 261011s2025 miu||||||m |||||||eng d
020 $a 9798280704039
035 $a (MiAaPQD)AAI31995387
035 $a AAI31995387
040 $a MiAaPQD $b eng $c MiAaPQD $e rda
100 1 $a Yusuf, Amirah Folashade, $e author. $0 (orcid)0000-0003-2755-4698 $3 3827312
245 1 0 $a Biological Effects of Azadirachta indica and Vernonia amygdalina on AKT Cell Survival and Cell Cycle Pathway in HT-29 Cell Line / $c Amirah Folashade Yusuf.
264 1 $a Ann Arbor : $b ProQuest Dissertations & Theses, $c 2025
300 $a 1 electronic resource (143 pages)
336 $a text $b txt $2 rdacontent
337 $a computer $b c $2 rdamedia
338 $a online resource $b cr $2 rdacarrier
500 $a Source: Dissertations Abstracts International, Volume: 86-12, Section: B.
500 $a Advisors: Yakubu, Momoh A. Committee members: Player, Audrey; Olufemi, Shodimu-Emmanuel; Oyagbemi, Ademola.
502 $b Ph.D. $c Texas Southern University $d 2025.
520 $a Numerous anticancer research outcomes exist but remain distant from effectively combating cancer occurrence and deaths. The situation requires investigation into alternative cancer treatments through medicinal plants. Cancer research needs advancement through ethnopharmacological and ethnobotanical approaches for developing therapeutic agents which produce fewer adverse effects. Several indications show that extracts from herbal plants demonstrate higher effectiveness. Both Azadirachta indica (A. indica) and Vernonia amygdalina (V. amygdalina) have been identified to have anticancer effects by various mechanisms of action. A. indica demonstrates anticancer activity through mechanisms that inhibit cell proliferation while triggering cell growth arrest, differentiation, and programmed cell death. V. amygdalina mechanisms of action involve reduction of cell viability while triggering apoptosis in cancer cell lines. This research distinguishes itself by investigating the impact of A. indica and V. amygdalina combination therapy on HT-29 cell survival and cell cycle regulatory proteins pathways. The plants Azadirachta indica known as Indian Neem and Vernonia amygdalina called Bitter leaf have earned widespread recognition for their multiple medicinal uses. The neem tree originated in Asia and Africa while the bitter leaf exists only in West Africa.The evaluation of their combined effects on HT-29 cancer cells is crucial to determine the safety and efficacy of these traditional therapeutic plants which have extensive applications across the globe. The regulation of cancer-induced changes in cellular regulatory pathways stands as a vital factor for cancer treatment success. Different analytical approaches were utilized in this research to examine Azadirachta indica and Vernonia amygdalina effects on cancer cells through biochemical interactions, cellular toxicity and therapeutic potential evaluation. Overall, our findings indicate that Azadirachta indica and Vernonia amygdalina modulate the expression of Akt, CCND1, and CDK4, suggesting their involvement in the regulation of cell survival and cell cycle progression in HT-29 cells. These results provide an understanding of the molecular mechanisms underlying Azadirachta indica and Vernonia amygdalina's paradoxical effects and their impact on cellular homeostasis, thus suggesting that A. indica and V. amygdalina possess the potential to be anti-cancer therapeutic agents. A thorough investigation of A. indica and V. amygdalina effects on PKB/AKT and its regulatory proteins downstream remains essential.
546 $a English
590 $a School code: 0441
650 4 $a Toxicology. $3 556884
650 4 $a Molecular biology. $3 517296
650 4 $a Cellular biology. $3 3172791
650 4 $a Plant sciences. $3 3173832
653 $a Azadirachta indica
653 $a HT 29 cell line
653 $a Medicinal plants
653 $a MTT assay
653 $a Vernonia amygdalina
653 $a Western blot
690 $a 0383
690 $a 0307
690 $a 0379
690 $a 0479
710 2 $a Texas Southern University. $b The College of Science, Engineering, and Technology. $e degree granting institution. $3 3815614
720 1 $a Yakubu, Momoh A. $e degree supervisor.
773 0 $t Dissertations Abstracts International $g 86-12B.
790 $a 0441
791 $a Ph.D.
792 $a 2025
856 4 0 $u https://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=31995387