東華大學圖書館 |

語系: 繁體中文

說明(常見問題)

回圖書館首頁

手機版館藏查詢

登入

回首頁 到查詢結果 [ null ]

切換: 標籤 | MARC模式 | ISBD

Exploring Developmental Toxicity Acr...

Yaghoobi, Ariga Bianca,

FindBook

Google Book

Amazon

博客來

Exploring Developmental Toxicity Across Diverse Chemical Classes: Insights From Zebrafish Models on Neurobehavioral Impacts /

紀錄類型:	書目-電子資源 : Monograph/item
正題名/作者:	Exploring Developmental Toxicity Across Diverse Chemical Classes: Insights From Zebrafish Models on Neurobehavioral Impacts // Ariga Bianca Yaghoobi.
作者:	Yaghoobi, Ariga Bianca,
面頁冊數:	1 electronic resource (221 pages)
附註:	Source: Dissertations Abstracts International, Volume: 86-02, Section: B.
Contained By:	Dissertations Abstracts International86-02B.
標題:	Developmental biology. -
電子資源:	https://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=30997600
ISBN:	9798383609781

Exploring Developmental Toxicity Across Diverse Chemical Classes: Insights From Zebrafish Models on Neurobehavioral Impacts /
Yaghoobi, Ariga Bianca,

Exploring Developmental Toxicity Across Diverse Chemical Classes: Insights From Zebrafish Models on Neurobehavioral Impacts /Ariga Bianca Yaghoobi. - 1 electronic resource (221 pages)

Source: Dissertations Abstracts International, Volume: 86-02, Section: B.

This dissertation employs zebrafish models as a robust tool for systematically assessing developmental toxicity across a spectrum of chemical classes. Zebrafish, owing to their genetic similarities to humans and transparent embryos that allow real-time observation, serve as an invaluable organism for unraveling the complexities of developmental toxicity. The initial investigation involved the screening of a diverse 91-compound library. The findings from this study highlighted the pivotal role of behavior as a sensitive and integrative endpoint for developmental toxicity assessment. It also established the importance of assessing it at more than one day during development. Intriguingly, compounds from various functional groups elicited distinctive behavioral abnormalities, underscoring the nuanced nature of toxic responses. Building upon the structure-activity relationship insights garnered from the first study, the subsequent investigation focused on non-dioxin-like PCB congeners. This study not only examined their developmental neurotoxicity but also elucidated a direct link between alterations in photomotor behavior and the sensitization of ryanodine receptors. This connection provides valuable mechanistic insights into the neurological impact of these compounds during development. The third study explored a novel class of compounds, halogenated pyrroles, with previously shown ryanodine receptor sensitization. The study further emphasized the importance of prolonged assessments in uncovering behavioral abnormalities and incorporated powerful imaging tools to understand the mechanism of action for observed behavioral changes. This nuanced approach contributes to a more comprehensive understanding of the developmental toxicity landscape associated with these compounds. Finally, the dissertation broadens its scope to encompass the assessment of 13 psychoactive compounds, including psychedelics, in larval zebrafish. This screening not only identified distinct neurotoxicity profiles but also serves as a valuable reference for the therapeutic development of these compounds. The inclusion of psychedelics in the study responds to the contemporary interest in their therapeutic potential and addresses a critical gap in the existing safety data. In essence, these interconnected studies collectively showcase the adaptability and versatility of zebrafish models in unraveling the intricate and multifaceted terrain of developmental toxicity and neurotoxicity induced by a diverse array of chemical exposures. The dissertation, through its systematic approach and mechanistic insights, significantly contributes to advancing our understanding of the potential risks associated with various chemical classes during critical stages of development.

English

ISBN: 9798383609781Subjects--Topical Terms:

592588
Developmental biology.
Subjects--Index Terms:

Developmental toxicity

Exploring Developmental Toxicity Across Diverse Chemical Classes: Insights From Zebrafish Models on Neurobehavioral Impacts /
LDR:04274nmm a22004333i 4500 001 2436473
005 20251023121219.5
006 m o d
007 cr|nu||||||||
008 261011s2024 miu||||||m |||||||eng d
020 $a 9798383609781
035 $a (MiAaPQD)AAI30997600
035 $a AAI30997600
040 $a MiAaPQD $b eng $c MiAaPQD $e rda
100 1 $a Yaghoobi, Ariga Bianca, $e author. $3 3827118
245 1 0 $a Exploring Developmental Toxicity Across Diverse Chemical Classes: Insights From Zebrafish Models on Neurobehavioral Impacts / $c Ariga Bianca Yaghoobi.
264 1 $a Ann Arbor : $b ProQuest Dissertations & Theses, $c 2024
300 $a 1 electronic resource (221 pages)
336 $a text $b txt $2 rdacontent
337 $a computer $b c $2 rdamedia
338 $a online resource $b cr $2 rdacarrier
500 $a Source: Dissertations Abstracts International, Volume: 86-02, Section: B.
500 $a Advisors: Lein, Pamela J. Committee members: Pessah, Isaac; Draper, Bruce.
502 $b Ph.D. $c University of California, Davis $d 2024.
520 $a This dissertation employs zebrafish models as a robust tool for systematically assessing developmental toxicity across a spectrum of chemical classes. Zebrafish, owing to their genetic similarities to humans and transparent embryos that allow real-time observation, serve as an invaluable organism for unraveling the complexities of developmental toxicity. The initial investigation involved the screening of a diverse 91-compound library. The findings from this study highlighted the pivotal role of behavior as a sensitive and integrative endpoint for developmental toxicity assessment. It also established the importance of assessing it at more than one day during development. Intriguingly, compounds from various functional groups elicited distinctive behavioral abnormalities, underscoring the nuanced nature of toxic responses. Building upon the structure-activity relationship insights garnered from the first study, the subsequent investigation focused on non-dioxin-like PCB congeners. This study not only examined their developmental neurotoxicity but also elucidated a direct link between alterations in photomotor behavior and the sensitization of ryanodine receptors. This connection provides valuable mechanistic insights into the neurological impact of these compounds during development. The third study explored a novel class of compounds, halogenated pyrroles, with previously shown ryanodine receptor sensitization. The study further emphasized the importance of prolonged assessments in uncovering behavioral abnormalities and incorporated powerful imaging tools to understand the mechanism of action for observed behavioral changes. This nuanced approach contributes to a more comprehensive understanding of the developmental toxicity landscape associated with these compounds. Finally, the dissertation broadens its scope to encompass the assessment of 13 psychoactive compounds, including psychedelics, in larval zebrafish. This screening not only identified distinct neurotoxicity profiles but also serves as a valuable reference for the therapeutic development of these compounds. The inclusion of psychedelics in the study responds to the contemporary interest in their therapeutic potential and addresses a critical gap in the existing safety data. In essence, these interconnected studies collectively showcase the adaptability and versatility of zebrafish models in unraveling the intricate and multifaceted terrain of developmental toxicity and neurotoxicity induced by a diverse array of chemical exposures. The dissertation, through its systematic approach and mechanistic insights, significantly contributes to advancing our understanding of the potential risks associated with various chemical classes during critical stages of development.
546 $a English
590 $a School code: 0029
650 4 $a Developmental biology. $3 592588
650 4 $a Neurosciences. $3 588700
650 4 $a Toxicology. $3 556884
650 4 $a Pharmacology. $3 634543
653 $a Developmental toxicity
653 $a Behavioral changes
653 $a Neurobehavioral impacts
653 $a Behavioral abnormalities
690 $a 0758
690 $a 0317
690 $a 0383
690 $a 0419
710 2 $a University of California, Davis. $b Pharmacology and Toxicology. $e degree granting institution. $3 3827119
720 1 $a Lein, Pamela J. $e degree supervisor.
773 0 $t Dissertations Abstracts International $g 86-02B.
790 $a 0029
791 $a Ph.D.
792 $a 2024
856 4 0 $u https://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=30997600