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Predicting Phase Behaviors of Biomol...

Li, Tianhao,

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Predicting Phase Behaviors of Biomolecular Condensates Using Minimal Models /

紀錄類型:	書目-電子資源 : Monograph/item
正題名/作者:	Predicting Phase Behaviors of Biomolecular Condensates Using Minimal Models // Tianhao Li.
作者:	Li, Tianhao,
面頁冊數:	1 electronic resource (182 pages)
附註:	Source: Dissertations Abstracts International, Volume: 86-12, Section: B.
Contained By:	Dissertations Abstracts International86-12B.
標題:	Biophysics. -
電子資源:	https://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=32038738
ISBN:	9798280747357

Predicting Phase Behaviors of Biomolecular Condensates Using Minimal Models /
Li, Tianhao,

Predicting Phase Behaviors of Biomolecular Condensates Using Minimal Models /Tianhao Li. - 1 electronic resource (182 pages)

Source: Dissertations Abstracts International, Volume: 86-12, Section: B.

Biomolecular condensates are membraneless compartments within living cells that play crucial roles in organizing cellular processes. Understanding their formation, function, and regulation has significant implications for elucidating biological processes and developing treatments for neurodegenerative diseases such as Alzheimer's. These condensates are widely believed to form through liquid-liquid phase separation (LLPS), driven by attractive molecular interactions. Predicting the phase behavior of biomolecular systems from these interactions remains a major challenge due to their inherent complexity. To address this, we introduced minimal models that capture essential features of biomolecular interactions. We developed simulation techniques and theoretical approaches to analyze these models. Our findings provide insights into the physical principles that govern phase separation, with potential applicability across a broad range of biomolecular systems.

English

ISBN: 9798280747357Subjects--Topical Terms:

518360
Biophysics.
Subjects--Index Terms:

Biomolecular condensates

Predicting Phase Behaviors of Biomolecular Condensates Using Minimal Models /
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520 $a Biomolecular condensates are membraneless compartments within living cells that play crucial roles in organizing cellular processes. Understanding their formation, function, and regulation has significant implications for elucidating biological processes and developing treatments for neurodegenerative diseases such as Alzheimer's. These condensates are widely believed to form through liquid-liquid phase separation (LLPS), driven by attractive molecular interactions. Predicting the phase behavior of biomolecular systems from these interactions remains a major challenge due to their inherent complexity. To address this, we introduced minimal models that capture essential features of biomolecular interactions. We developed simulation techniques and theoretical approaches to analyze these models. Our findings provide insights into the physical principles that govern phase separation, with potential applicability across a broad range of biomolecular systems.
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