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Nuclear Speckles: The Intersection o...

Dion, William Aaron,

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Nuclear Speckles: The Intersection of Ultradian Chronobiology and Proteostasis /

紀錄類型:	書目-電子資源 : Monograph/item
正題名/作者:	Nuclear Speckles: The Intersection of Ultradian Chronobiology and Proteostasis // William Aaron Dion.
作者:	Dion, William Aaron,
面頁冊數:	1 electronic resource (256 pages)
附註:	Source: Dissertations Abstracts International, Volume: 86-11, Section: B.
Contained By:	Dissertations Abstracts International86-11B.
標題:	Cellular biology. -
電子資源:	https://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=31933938
ISBN:	9798314868102

Nuclear Speckles: The Intersection of Ultradian Chronobiology and Proteostasis /
Dion, William Aaron,

Nuclear Speckles: The Intersection of Ultradian Chronobiology and Proteostasis /William Aaron Dion. - 1 electronic resource (256 pages)

Source: Dissertations Abstracts International, Volume: 86-11, Section: B.

The foundational question of my dissertation research was "how do ~12-hour biological rhythms intersect with proteostasis?". I begin with a review of ultradian chronobiology (Chapter 1) that will equip the reader with the relevant background information to understand the following two chapters. Next, I present our study linking the nuclear speckle's ~12-hour rhythms of liquidliquid phase separation dynamics to ultradian rhythms of proteostasis gene expression (Chapter 2). Then, I report our research establishing the liquid-liquid phase separation dynamics of the nuclear speckle as a druggable target to modulate the cell's ability to maintain a balanced proteome (Chapter 3). Finally, I provide concluding remarks that I hope leave the reader excited for the future of nuclear speckle research. This dissertation coherently explains the importance of ultradian chronobiology to organismal health, and details how the simple aforementioned question led to the establishment of the nuclear speckle as a druggable target to boost cellular proteostasis.

English

ISBN: 9798314868102Subjects--Topical Terms:

3172791
Cellular biology.
Subjects--Index Terms:

Chronobiology

Nuclear Speckles: The Intersection of Ultradian Chronobiology and Proteostasis /
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502 $b Ph.D. $c University of Pittsburgh $d 2025.
520 $a The foundational question of my dissertation research was "how do ~12-hour biological rhythms intersect with proteostasis?". I begin with a review of ultradian chronobiology (Chapter 1) that will equip the reader with the relevant background information to understand the following two chapters. Next, I present our study linking the nuclear speckle's ~12-hour rhythms of liquidliquid phase separation dynamics to ultradian rhythms of proteostasis gene expression (Chapter 2). Then, I report our research establishing the liquid-liquid phase separation dynamics of the nuclear speckle as a druggable target to modulate the cell's ability to maintain a balanced proteome (Chapter 3). Finally, I provide concluding remarks that I hope leave the reader excited for the future of nuclear speckle research. This dissertation coherently explains the importance of ultradian chronobiology to organismal health, and details how the simple aforementioned question led to the establishment of the nuclear speckle as a druggable target to boost cellular proteostasis.
546 $a English
590 $a School code: 0178
650 4 $a Cellular biology. $3 3172791
650 4 $a Bioinformatics. $3 553671
650 4 $a Molecular biology. $3 517296
653 $a Chronobiology
653 $a Proteostasis
653 $a Nuclear speckle research
653 $a Cellular proteostasis
653 $a Ultradian chronobiology
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690 $a 0715
690 $a 0307
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720 1 $a Zhu, Bokai $e degree supervisor.
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791 $a Ph.D.
792 $a 2025
856 4 0 $u https://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=31933938