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Effects of Juvenile Hormone Analogue...

Hu, Xuelei,

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Effects of Juvenile Hormone Analogue Insecticides, Fenoxycarb and Methoprene, on Neocaridina davidi and Moina macrocopa /

紀錄類型:	書目-電子資源 : Monograph/item
正題名/作者:	Effects of Juvenile Hormone Analogue Insecticides, Fenoxycarb and Methoprene, on Neocaridina davidi and Moina macrocopa // Xuelei Hu.
作者:	Hu, Xuelei,
面頁冊數:	1 electronic resource (159 pages)
附註:	Source: Dissertations Abstracts International, Volume: 81-09, Section: B.
Contained By:	Dissertations Abstracts International81-09B.
標題:	Environmental science. -
電子資源:	https://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=27784035
ISBN:	9781392799000

Effects of Juvenile Hormone Analogue Insecticides, Fenoxycarb and Methoprene, on Neocaridina davidi and Moina macrocopa /
Hu, Xuelei,

Effects of Juvenile Hormone Analogue Insecticides, Fenoxycarb and Methoprene, on Neocaridina davidi and Moina macrocopa /Xuelei Hu. - 1 electronic resource (159 pages)

Source: Dissertations Abstracts International, Volume: 81-09, Section: B.

The increasing quantities of insecticides released into water bodies severely affect the health of the aquatic ecosystem. For instance, juvenile hormone analogue (JHA) insecticides are endocrine disrupters that interfere with hormonal action in insects by mimicking their juvenile hormones (JH). As the structure and functions of methyl farnesoate in crustaceans are similar to those of JH in insects, exogenous JHA insecticides could have adverse effects on the development and reproduction of crustaceans. Through phenotypic observation and transcriptome analysis, this study examined the toxic effects of two representative JHA insecticides, fenoxycarb and methoprene, on two freshwater crustacean models, Neocaridina davidi and Moina macrocopa.The results show that both insecticides had detrimental effects on cherry shrimp,but fenoxycarb was more toxic than methoprene. Chronic exposure to these insecticides reduced the shrimp's body length and molting frequency. Based on transcriptome annotations for N. davidi, I identified important gene homologues that were active in both insect JH biosynthetic and degradative pathways as well as JH and ecdysteroid signaling pathways. Chronic treatments with JHAs had significant effects on these genes in N. davidi. RNA sequencing data showed that genes involved in the pathways related to cuticle development, serine protease activity, and carbohydrate, peptide and lipid metabolic processes were differentially expressed in shrimp exposed to JHAs.Results in M. macrocopa indicate that the 24-h and 48-h LC50 values for fenoxycarb and methoprene were 0.53 and 0.32 mg/L and 0.70 and 0.54 mg/L, respectively. Chronic exposures to fenoxycarb and methoprene caused a series of toxic effects in M. macrocopa; they shortened its life expectancy, repressed its bodydevelopment, and reduced its fecundity. These JHAs also disturbed the expression of genes involved in the JH signaling pathway, in cuticle development, and in the carbohydrate, amino acid, and ATP metabolic processes. Moreover, JHA exposure inhibited the growth and reproduction of the F1 generation of M. macrocopa although these neonates were not exposed to the chemicals. In addition, changes in the expression of genes related to histone methylation indicated that epigenetic changes may promote the transgenerational impairment in M. macrocopa.To summarize, these experimental results demonstrated the toxic effects of fenoxycarb and methoprene on aquatic non-target aquatic organisms. Considering JHAs can easily adsorb in suspended particles and sediments, and bioaccumulate in crustaceans, these insecticides may pose a potential toxic risk to non-target aquatic organisms. The damage done by these JHA insecticides to the aquatic environment is worthy of attention and tight regulations.

English

ISBN: 9781392799000Subjects--Topical Terms:

677245
Environmental science.
Subjects--Index Terms:

Juvenile hormone analogue

Effects of Juvenile Hormone Analogue Insecticides, Fenoxycarb and Methoprene, on Neocaridina davidi and Moina macrocopa /
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520 $a The increasing quantities of insecticides released into water bodies severely affect the health of the aquatic ecosystem. For instance, juvenile hormone analogue (JHA) insecticides are endocrine disrupters that interfere with hormonal action in insects by mimicking their juvenile hormones (JH). As the structure and functions of methyl farnesoate in crustaceans are similar to those of JH in insects, exogenous JHA insecticides could have adverse effects on the development and reproduction of crustaceans. Through phenotypic observation and transcriptome analysis, this study examined the toxic effects of two representative JHA insecticides, fenoxycarb and methoprene, on two freshwater crustacean models, Neocaridina davidi and Moina macrocopa.The results show that both insecticides had detrimental effects on cherry shrimp,but fenoxycarb was more toxic than methoprene. Chronic exposure to these insecticides reduced the shrimp's body length and molting frequency. Based on transcriptome annotations for N. davidi, I identified important gene homologues that were active in both insect JH biosynthetic and degradative pathways as well as JH and ecdysteroid signaling pathways. Chronic treatments with JHAs had significant effects on these genes in N. davidi. RNA sequencing data showed that genes involved in the pathways related to cuticle development, serine protease activity, and carbohydrate, peptide and lipid metabolic processes were differentially expressed in shrimp exposed to JHAs.Results in M. macrocopa indicate that the 24-h and 48-h LC50 values for fenoxycarb and methoprene were 0.53 and 0.32 mg/L and 0.70 and 0.54 mg/L, respectively. Chronic exposures to fenoxycarb and methoprene caused a series of toxic effects in M. macrocopa; they shortened its life expectancy, repressed its bodydevelopment, and reduced its fecundity. These JHAs also disturbed the expression of genes involved in the JH signaling pathway, in cuticle development, and in the carbohydrate, amino acid, and ATP metabolic processes. Moreover, JHA exposure inhibited the growth and reproduction of the F1 generation of M. macrocopa although these neonates were not exposed to the chemicals. In addition, changes in the expression of genes related to histone methylation indicated that epigenetic changes may promote the transgenerational impairment in M. macrocopa.To summarize, these experimental results demonstrated the toxic effects of fenoxycarb and methoprene on aquatic non-target aquatic organisms. Considering JHAs can easily adsorb in suspended particles and sediments, and bioaccumulate in crustaceans, these insecticides may pose a potential toxic risk to non-target aquatic organisms. The damage done by these JHA insecticides to the aquatic environment is worthy of attention and tight regulations.
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