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Multiscale Modeling of the Skin's Bi...

Witt, Nathaniel James,

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Multiscale Modeling of the Skin's Biomechanics and Aging /

紀錄類型:	書目-電子資源 : Monograph/item
正題名/作者:	Multiscale Modeling of the Skin's Biomechanics and Aging // Nathaniel James Witt.
作者:	Witt, Nathaniel James,
面頁冊數:	1 electronic resource (104 pages)
附註:	Source: Dissertations Abstracts International, Volume: 86-01, Section: B.
Contained By:	Dissertations Abstracts International86-01B.
標題:	Biomedical engineering. -
電子資源:	https://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=31239017
ISBN:	9798383187616

Multiscale Modeling of the Skin's Biomechanics and Aging /
Witt, Nathaniel James,

Multiscale Modeling of the Skin's Biomechanics and Aging /Nathaniel James Witt. - 1 electronic resource (104 pages)

Source: Dissertations Abstracts International, Volume: 86-01, Section: B.

As the population ages and obesity rates rise, the incidence of skin injuries and hospitalizations is projected to escalate. By 2024, the financial burden associated solely with treating chronic wounds is estimated to exceed $22 billion. With advancing age, the skin undergoes notable changes, leading to increased susceptibility to wrinkles, fragility, and compromised wound healing. These alterations stem from shifts in the underlying structure of the skin, particularly within the dermal layer. Reductions in hydrating proteins and disruptions in the collagen network, responsible for skin strength, are key factors in this process. However, comprehending the precise implications of changes in the skin's mechanics and health poses a challenge. While mechanical forces exerted on the skin influence cellular behavior and repair mechanisms, the intricacies of these interactions remain incompletely understood. This is particularly true of the structure-function relationships deriving from the dermal microstructure and their contributions to the biomechanical properties, failure characteristics, and changes with aging of the skin. The studies contained herein aim to investigate these underlying mechanisms via computational models that allow for detailed analysis at the tissue and microstructural levels. Ultimately, this may yield advancements with potential implications for enhancing wound healing and promoting overall skin health in the future.

English

ISBN: 9798383187616Subjects--Topical Terms:

535387
Biomedical engineering.
Subjects--Index Terms:

Collagen network

Multiscale Modeling of the Skin's Biomechanics and Aging /
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520 $a As the population ages and obesity rates rise, the incidence of skin injuries and hospitalizations is projected to escalate. By 2024, the financial burden associated solely with treating chronic wounds is estimated to exceed $22 billion. With advancing age, the skin undergoes notable changes, leading to increased susceptibility to wrinkles, fragility, and compromised wound healing. These alterations stem from shifts in the underlying structure of the skin, particularly within the dermal layer. Reductions in hydrating proteins and disruptions in the collagen network, responsible for skin strength, are key factors in this process. However, comprehending the precise implications of changes in the skin's mechanics and health poses a challenge. While mechanical forces exerted on the skin influence cellular behavior and repair mechanisms, the intricacies of these interactions remain incompletely understood. This is particularly true of the structure-function relationships deriving from the dermal microstructure and their contributions to the biomechanical properties, failure characteristics, and changes with aging of the skin. The studies contained herein aim to investigate these underlying mechanisms via computational models that allow for detailed analysis at the tissue and microstructural levels. Ultimately, this may yield advancements with potential implications for enhancing wound healing and promoting overall skin health in the future.
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590 $a School code: 0096
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650 4 $a Aging. $3 543123
650 4 $a Biomechanics. $3 548685
650 4 $a Dermatology. $3 829009
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653 $a Dermis
653 $a Fiber networks
653 $a Multiphoton microscopy
653 $a Biomechanical properties
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