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Cortical Function, Gait Alterations,...

Lee, Soyoung,

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Cortical Function, Gait Alterations, and Central Sensitization in People With Knee Osteoarthritis /

紀錄類型:	書目-電子資源 : Monograph/item
正題名/作者:	Cortical Function, Gait Alterations, and Central Sensitization in People With Knee Osteoarthritis // Soyoung Lee.
作者:	Lee, Soyoung,
面頁冊數:	1 electronic resource (89 pages)
附註:	Source: Dissertations Abstracts International, Volume: 86-07, Section: B.
Contained By:	Dissertations Abstracts International86-07B.
標題:	Physical therapy. -
電子資源:	https://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=31768170
ISBN:	9798302170712

Cortical Function, Gait Alterations, and Central Sensitization in People With Knee Osteoarthritis /
Lee, Soyoung,

Cortical Function, Gait Alterations, and Central Sensitization in People With Knee Osteoarthritis /Soyoung Lee. - 1 electronic resource (89 pages)

Source: Dissertations Abstracts International, Volume: 86-07, Section: B.

For healthy individuals, walking is an automatic locomotion. However, for people with knee osteoarthritis (OA) who often have chronic knee pain and reduced physical function, walking can be less automatic movement that accompanies altered patterns and requires fine motor control. Over-recruitment of the prefrontal cortex (PFC), a region of executive function, during walking can be the underlying neurobiology of disrupted gait automaticity. Therefore, the aim of the Study 1 was to determine the association between the over-recruitment of PFC and altered gait patterns in single- and dual-task walking paradigms. We found that higher activation in subregions of PFC is associated with low variability in step duration (better gait automaticity) during dual-task walking in people with knee OA. In Study 2, we investigated whether the presence of central sensitization, a major biological cause of chronic knee pain, is related to the over-recruitment of PFC and the loss of gait automaticity. Since central pain sensitization involves alterations in activity and connectivity across multiple brain regions, including PFC, central sensitization could be one mechanism by which chronic pain leads to plasticity in brain function and less automatic gait patterns. Study 2 has found that people with a low-pressure pain threshold (PPT) at the unaffected joint (indicating the presence of central sensitization) show greater activation in subregions of the PFC and higher stride length variability (worse gait automaticity) compared to those with a high-PPT during walking. Overall, these findings suggest that people with knee OA may require greater executive control through PFC modulation during complex walking conditions to maintain gait automaticity. Additionally, Study 2 suggests that individuals with knee OA and central pain sensitization may need enhanced executive control during walking compared to those without, highlighting central sensitization as a potential therapeutic target for restoring normal walking function.

English

ISBN: 9798302170712Subjects--Topical Terms:

588713
Physical therapy.
Subjects--Index Terms:

Gait automaticity

Cortical Function, Gait Alterations, and Central Sensitization in People With Knee Osteoarthritis /
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520 $a For healthy individuals, walking is an automatic locomotion. However, for people with knee osteoarthritis (OA) who often have chronic knee pain and reduced physical function, walking can be less automatic movement that accompanies altered patterns and requires fine motor control. Over-recruitment of the prefrontal cortex (PFC), a region of executive function, during walking can be the underlying neurobiology of disrupted gait automaticity. Therefore, the aim of the Study 1 was to determine the association between the over-recruitment of PFC and altered gait patterns in single- and dual-task walking paradigms. We found that higher activation in subregions of PFC is associated with low variability in step duration (better gait automaticity) during dual-task walking in people with knee OA. In Study 2, we investigated whether the presence of central sensitization, a major biological cause of chronic knee pain, is related to the over-recruitment of PFC and the loss of gait automaticity. Since central pain sensitization involves alterations in activity and connectivity across multiple brain regions, including PFC, central sensitization could be one mechanism by which chronic pain leads to plasticity in brain function and less automatic gait patterns. Study 2 has found that people with a low-pressure pain threshold (PPT) at the unaffected joint (indicating the presence of central sensitization) show greater activation in subregions of the PFC and higher stride length variability (worse gait automaticity) compared to those with a high-PPT during walking. Overall, these findings suggest that people with knee OA may require greater executive control through PFC modulation during complex walking conditions to maintain gait automaticity. Additionally, Study 2 suggests that individuals with knee OA and central pain sensitization may need enhanced executive control during walking compared to those without, highlighting central sensitization as a potential therapeutic target for restoring normal walking function.
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650 4 $a Biomedical engineering. $3 535387
650 4 $a Medicine. $3 641104
650 4 $a Kinesiology. $3 517627
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653 $a Osteoarthritis
653 $a Prefrontal cortex
653 $a Central sensitization
653 $a Pressure pain threshold
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