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Investigation of Metastatic Potentia...

Turgut, Deni̇z Cemre.

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Investigation of Metastatic Potential of Breast Cancer Cells in Lung-on-a-Chip = = Meme kanseri hucrelerinin metastatik potansiyelinin cip-uzeri-akciger kullanilarak arastirilmasi.

Record Type:	Electronic resources : Monograph/item
Title/Author:	Investigation of Metastatic Potential of Breast Cancer Cells in Lung-on-a-Chip =/
Reminder of title:	Meme kanseri hucrelerinin metastatik potansiyelinin cip-uzeri-akciger kullanilarak arastirilmasi.
Author:	Turgut, Deni̇z Cemre.
Published:	Ann Arbor : ProQuest Dissertations & Theses, : 2023,
Description:	46 p.
Notes:	Source: Masters Abstracts International, Volume: 86-02.
Contained By:	Masters Abstracts International86-02.
Subject:	Physiology. -
Online resource:	https://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=31539767
ISBN:	9798383533710

Investigation of Metastatic Potential of Breast Cancer Cells in Lung-on-a-Chip = = Meme kanseri hucrelerinin metastatik potansiyelinin cip-uzeri-akciger kullanilarak arastirilmasi.
Turgut, Deni̇z Cemre.

Investigation of Metastatic Potential of Breast Cancer Cells in Lung-on-a-Chip =Meme kanseri hucrelerinin metastatik potansiyelinin cip-uzeri-akciger kullanilarak arastirilmasi. - Ann Arbor : ProQuest Dissertations & Theses, 2023 - 46 p.

Source: Masters Abstracts International, Volume: 86-02.

Thesis (M.S.)--Izmir Institute of Technology (Turkey), 2023.

Breast cancer stands as the most prevalent cancer among women and ranks as the second leading cause of cancer-related fatalities globally. The primary contributor to mortality is metastasis. Triple negative breast cancer exhibits a tendency to metastasize to the lungs, as lungs identified as one of the most common targets of breast cancer metastases. However, to study the precise mechanisms governing this organ-specific metastatic pattern requires a sophisticated 3D lung model, which can truly recapitulate lung physiology and architecture. This study explores the metastatic behaviour of MDA-MB-231 breast cancer cells and their interaction with tumour-associated macrophages (TAMs) within a 3D lung model created through a novel biopsy punch technique. The obtained punched lung tissues are integrated into microphysiological systems presenting a hybrid 3D culture model for lung studies. The key findings of this research reveal the effectiveness of biopsy punches in preserving tissue integrity and ensuring a consistent size distribution. Additionally, the study demonstrates the viability of lung tissues for up to 72 hours. Most notably, MDA-MB-231 cells exhibit a significant capacity to invade the punched lung tissues with even greater infiltration observed in the presence of differentiated U-937 cells. These findings provide valuable insights into the metastatic potential of breast cancer cells and highlight the importance of TAMs in facilitating cancer progression within a 3D lung microenvironment. This novel tissue culture technique opens new avenues for studying cancer metastasis, precision medicine and tumour-microenvironment interactions.

ISBN: 9798383533710Subjects--Topical Terms:

518431
Physiology.
Subjects--Index Terms:

Breast cancer

Investigation of Metastatic Potential of Breast Cancer Cells in Lung-on-a-Chip = = Meme kanseri hucrelerinin metastatik potansiyelinin cip-uzeri-akciger kullanilarak arastirilmasi.
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245 1 0 $a Investigation of Metastatic Potential of Breast Cancer Cells in Lung-on-a-Chip = $b Meme kanseri hucrelerinin metastatik potansiyelinin cip-uzeri-akciger kullanilarak arastirilmasi.
260 1 $a Ann Arbor : $b ProQuest Dissertations & Theses, $c 2023
300 $a 46 p.
500 $a Source: Masters Abstracts International, Volume: 86-02.
500 $a Advisor: Pesen Okvur, Devri̇m.
502 $a Thesis (M.S.)--Izmir Institute of Technology (Turkey), 2023.
520 $a Breast cancer stands as the most prevalent cancer among women and ranks as the second leading cause of cancer-related fatalities globally. The primary contributor to mortality is metastasis. Triple negative breast cancer exhibits a tendency to metastasize to the lungs, as lungs identified as one of the most common targets of breast cancer metastases. However, to study the precise mechanisms governing this organ-specific metastatic pattern requires a sophisticated 3D lung model, which can truly recapitulate lung physiology and architecture. This study explores the metastatic behaviour of MDA-MB-231 breast cancer cells and their interaction with tumour-associated macrophages (TAMs) within a 3D lung model created through a novel biopsy punch technique. The obtained punched lung tissues are integrated into microphysiological systems presenting a hybrid 3D culture model for lung studies. The key findings of this research reveal the effectiveness of biopsy punches in preserving tissue integrity and ensuring a consistent size distribution. Additionally, the study demonstrates the viability of lung tissues for up to 72 hours. Most notably, MDA-MB-231 cells exhibit a significant capacity to invade the punched lung tissues with even greater infiltration observed in the presence of differentiated U-937 cells. These findings provide valuable insights into the metastatic potential of breast cancer cells and highlight the importance of TAMs in facilitating cancer progression within a 3D lung microenvironment. This novel tissue culture technique opens new avenues for studying cancer metastasis, precision medicine and tumour-microenvironment interactions.
520 $a Meme kanseri kadinlar arasinda en sik gorulen kanser olup, dunya capinda kansere bagli olumlerin onde gelen ikinci nedenidir. Mortaliteye katkida bulunan birincil faktor ise metastazdir. Uclu negatif meme kanseri, akcigerlere metastaz yapma egilimi gosterir. Bununla birlikte akcigerler, meme kanseri metastazlarinin en yaygin hedeflerinden biri olarak tanimlanir. Bu yuzden, akcigere ozgu metastatik hareketi yoneten kesin mekanizmalari incelemek, akciger fizyolojisini ve yapisini gercekten karsilayabilen bir 3 boyutlu akciger modelini gerektirir. Bu calisma, MDA-MB-231 meme kanseri hucrelerinin metastatik davranisini ve bunlarin, yeni bir biyopsi delme teknigi ile olusturulan 3 boyutlu akciger modeli icerisinde tumorle iliskili makrofajlarin (TAM'ler) etkisini arastirmaktadir. Elde edilen delinmis akciger dokulari, akciger calismalari icin hibrit bir 3 boyutlu kultur modeli sunan mikrofizyolojik sistemlere entegre edilir. Bu arastirmanin temel bulgulari, biyopsi yumruklarinin doku butunlugunu koruma ve tutarli bir boyut dagilimi saglama konusundaki etkinligini ortaya koymaktadir. Ayrica calisma, biyopsi uygulanmis akciger dokularinin 72 saate kadar canliligini koruyabildigini de ortaya koymaktadir. En onemlisi, MDA-MB-231 hucreleri, farklilasmis U-937 hucrelerinin varliginda gozlenen daha da buyuk bir gocle delinmis akciger dokularini istila etme konusunda onemli bir kapasite sergiler. Bu bulgular, meme kanseri hucrelerinin metastatik potansiyeli hakkinda degerli bilgiler saglar ve TAM'lerin, 3 boyutlu akciger mikro ortaminda kanser ilerlemesine olan yardimci rolunun onemini vurgular. Bu yeni doku kulturu teknigi, kanser metastazi, hassas tip ve tumor-mikrocevre etkilesimlerini incelemek icin yeni bir arastirma teknigi ortaya koymaktadir.
590 $a School code: 2215.
650 4 $a Physiology. $3 518431
650 4 $a Epidermal growth factor. $3 2107074
650 4 $a Medical prognosis. $3 3561728
650 4 $a Metastasis. $3 818532
650 4 $a Fibroblasts. $3 1573241
650 4 $a Blood vessels. $3 3561732
650 4 $a Carbon dioxide. $3 587886
650 4 $a Biopsy. $3 1360224
650 4 $a Medical research. $2 bicssc $3 1556686
650 4 $a Extracellular matrix. $3 684719
650 4 $a Glucose. $3 2084335
650 4 $a Penicillin. $3 3683589
650 4 $a Lungs. $3 669904
650 4 $a Pathophysiology. $3 3561792
650 4 $a Cell culture. $3 604671
650 4 $a Breast cancer. $3 3543523
650 4 $a Molecular biology. $3 517296
653 $a Breast cancer
653 $a Tumour-associated macrophages
690 $a 0719
690 $a 0307
710 2 $a Izmir Institute of Technology (Turkey). $3 3561138
773 0 $t Masters Abstracts International $g 86-02.
790 $a 2215
791 $a M.S.
792 $a 2023
793 $a English
856 4 0 $u https://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=31539767