東華大學圖書館 |

Language: English

Help

回圖書館首頁

手機版館藏查詢

Back to Search results for [ null ]

Switch To: Labeled | MARC Mode | ISBD

Quantitative Evaluation of Simultane...

Schramm, Haley M.

Linked to FindBook

Google Book

Amazon

博客來

Quantitative Evaluation of Simultaneous Selective Ion Clustering and Hydrogen/Deuterium Exchange.

Record Type:	Electronic resources : Monograph/item
Title/Author:	Quantitative Evaluation of Simultaneous Selective Ion Clustering and Hydrogen/Deuterium Exchange./
Author:	Schramm, Haley M.
Published:	Ann Arbor : ProQuest Dissertations & Theses, : 2024,
Description:	191 p.
Notes:	Source: Dissertations Abstracts International, Volume: 85-12, Section: B.
Contained By:	Dissertations Abstracts International85-12B.
Subject:	Chemistry. -
Online resource:	https://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=30995980
ISBN:	9798383123409

Quantitative Evaluation of Simultaneous Selective Ion Clustering and Hydrogen/Deuterium Exchange.
Schramm, Haley M.

Quantitative Evaluation of Simultaneous Selective Ion Clustering and Hydrogen/Deuterium Exchange. - Ann Arbor : ProQuest Dissertations & Theses, 2024 - 191 p.

Source: Dissertations Abstracts International, Volume: 85-12, Section: B.

Thesis (Ph.D.)--Washington State University, 2024.

Recent efforts in ion mobility coupled to mass spectrometry have enhanced the confidence in describing gas-phase ion structures. Hydrogen/deuterium exchange is highly studied in condensed phases as a chemical tool for indirect structural analysis, but wider adoption of gas-phase methods is hindered by low deuterium incorporation and restrictions of in vacuo experiments. To combine the chemical tools of ion clustering and isotope exchange with the physical separation tool of ion mobility, an atmospheric pressure drift cell was used as a reaction vessel. The increased collision rate of ions and neutrals at ambient conditions enabled increased exchange for amino acids and peptides and comparable exchange levels in proteins in millisecond reactions times. The multimodal data obtained from this method shows a direct link between localized ion solvation and exchange kinetics. Multiple distinctly reactive ion populations are detected in all the analytes studied with unprecedented speed and selectivity. These experiments elucidated new insights into the structure and solvation of single amino acids, peptide, and protein ions currently unattainable with commercial instrumentation.

ISBN: 9798383123409Subjects--Topical Terms:

516420
Chemistry.
Subjects--Index Terms:

Mass spectrometry

Quantitative Evaluation of Simultaneous Selective Ion Clustering and Hydrogen/Deuterium Exchange.
LDR:02452nmm a2200421 4500 001 2401576
005 20241022110525.5
006 m o d
007 cr#unu||||||||
008 251215s2024 ||||||||||||||||| ||eng d
020 $a 9798383123409
035 $a (MiAaPQ)AAI30995980
035 $a AAI30995980
035 $a 2401576
040 $a MiAaPQ $c MiAaPQ
100 1 $a Schramm, Haley M. $0 (orcid)0000-0002-1588-7949 $3 3771675
245 1 0 $a Quantitative Evaluation of Simultaneous Selective Ion Clustering and Hydrogen/Deuterium Exchange.
260 1 $a Ann Arbor : $b ProQuest Dissertations & Theses, $c 2024
300 $a 191 p.
500 $a Source: Dissertations Abstracts International, Volume: 85-12, Section: B.
500 $a Advisor: Clowers, Brian H.
502 $a Thesis (Ph.D.)--Washington State University, 2024.
520 $a Recent efforts in ion mobility coupled to mass spectrometry have enhanced the confidence in describing gas-phase ion structures. Hydrogen/deuterium exchange is highly studied in condensed phases as a chemical tool for indirect structural analysis, but wider adoption of gas-phase methods is hindered by low deuterium incorporation and restrictions of in vacuo experiments. To combine the chemical tools of ion clustering and isotope exchange with the physical separation tool of ion mobility, an atmospheric pressure drift cell was used as a reaction vessel. The increased collision rate of ions and neutrals at ambient conditions enabled increased exchange for amino acids and peptides and comparable exchange levels in proteins in millisecond reactions times. The multimodal data obtained from this method shows a direct link between localized ion solvation and exchange kinetics. Multiple distinctly reactive ion populations are detected in all the analytes studied with unprecedented speed and selectivity. These experiments elucidated new insights into the structure and solvation of single amino acids, peptide, and protein ions currently unattainable with commercial instrumentation.
590 $a School code: 0251.
650 4 $a Chemistry. $3 516420
650 4 $a Physical chemistry. $3 1981412
650 4 $a Inorganic chemistry. $3 3173556
650 4 $a Analytical chemistry. $3 3168300
650 4 $a Computational chemistry. $3 3350019
653 $a Mass spectrometry
653 $a Hydrogen/deuterium exchange
653 $a Physical separation tool
653 $a Ion mobility
653 $a Exchange kinetics
690 $a 0485
690 $a 0488
690 $a 0486
690 $a 0219
690 $a 0494
710 2 $a Washington State University. $b Department of Chemistry. $3 3686374
773 0 $t Dissertations Abstracts International $g 85-12B.
790 $a 0251
791 $a Ph.D.
792 $a 2024
793 $a English
856 4 0 $u https://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=30995980