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Investigating Smooth Muscle Myosin D...

Bennett, Margaret.

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Investigating Smooth Muscle Myosin Dynamics and Assembly in Physiology and Pathology.

Record Type:	Electronic resources : Monograph/item
Title/Author:	Investigating Smooth Muscle Myosin Dynamics and Assembly in Physiology and Pathology./
Author:	Bennett, Margaret.
Published:	Ann Arbor : ProQuest Dissertations & Theses, : 2023,
Description:	103 p.
Notes:	Source: Dissertations Abstracts International, Volume: 85-01, Section: B.
Contained By:	Dissertations Abstracts International85-01B.
Subject:	Cellular biology. -
Online resource:	https://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=30570656
ISBN:	9798379944001

Investigating Smooth Muscle Myosin Dynamics and Assembly in Physiology and Pathology.
Bennett, Margaret.

Investigating Smooth Muscle Myosin Dynamics and Assembly in Physiology and Pathology. - Ann Arbor : ProQuest Dissertations & Theses, 2023 - 103 p.

Source: Dissertations Abstracts International, Volume: 85-01, Section: B.

Thesis (Ph.D.)--Loyola University Chicago, 2023.

Vascular smooth muscle cells (SMCs) line blood vessels throughout the body, where they dynamically alter vessel diameter to regulate blood pressure, provide structural integrity, and absorb shock on a beat-to-beat timescale. These mechanical and contractile functions are powered by the actin and smooth muscle myosin 2 cytoskeleton. To function, smooth muscle myosin transitions between an inactive monomeric state and an active filamentous state, which can then perform work on actin. Understanding the regulation of smooth muscle myosin activation at the molecular and cellular level is foundational for understanding tissue-level smooth muscle function and dysfunction in disease states. Indeed, mutations in smooth muscle myosin and dysregulation of actomyosin contractility are known drivers of smooth muscle pathologies, such as aortic aneurysms. The overarching goal of this work is to explore filament assembly and dynamics of smooth muscle myosin under normal physiological conditions, and look into how these may be changed in novel and pathology associated mutations.

ISBN: 9798379944001Subjects--Topical Terms:

3172791
Cellular biology.
Subjects--Index Terms:

Vascular smooth muscle cells

Investigating Smooth Muscle Myosin Dynamics and Assembly in Physiology and Pathology.
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245 1 0 $a Investigating Smooth Muscle Myosin Dynamics and Assembly in Physiology and Pathology.
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300 $a 103 p.
500 $a Source: Dissertations Abstracts International, Volume: 85-01, Section: B.
500 $a Advisor: Beach, Jordan.
502 $a Thesis (Ph.D.)--Loyola University Chicago, 2023.
520 $a Vascular smooth muscle cells (SMCs) line blood vessels throughout the body, where they dynamically alter vessel diameter to regulate blood pressure, provide structural integrity, and absorb shock on a beat-to-beat timescale. These mechanical and contractile functions are powered by the actin and smooth muscle myosin 2 cytoskeleton. To function, smooth muscle myosin transitions between an inactive monomeric state and an active filamentous state, which can then perform work on actin. Understanding the regulation of smooth muscle myosin activation at the molecular and cellular level is foundational for understanding tissue-level smooth muscle function and dysfunction in disease states. Indeed, mutations in smooth muscle myosin and dysregulation of actomyosin contractility are known drivers of smooth muscle pathologies, such as aortic aneurysms. The overarching goal of this work is to explore filament assembly and dynamics of smooth muscle myosin under normal physiological conditions, and look into how these may be changed in novel and pathology associated mutations.
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650 4 $a Physiology. $3 518431
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653 $a Pathology associated mutations
653 $a Actomyosin
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