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Integrating Machine Learning and Pro...

Zatorski, Nicole.

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Integrating Machine Learning and Protein Structural Features to Predict Drug Toxicity.

紀錄類型:	書目-電子資源 : Monograph/item
正題名/作者:	Integrating Machine Learning and Protein Structural Features to Predict Drug Toxicity./
作者:	Zatorski, Nicole.
出版者:	Ann Arbor : ProQuest Dissertations & Theses, : 2023,
面頁冊數:	216 p.
附註:	Source: Dissertations Abstracts International, Volume: 85-01, Section: B.
Contained By:	Dissertations Abstracts International85-01B.
標題:	Computational chemistry. -
電子資源:	https://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=30568087
ISBN:	9798379796013

Integrating Machine Learning and Protein Structural Features to Predict Drug Toxicity.
Zatorski, Nicole.

Integrating Machine Learning and Protein Structural Features to Predict Drug Toxicity. - Ann Arbor : ProQuest Dissertations & Theses, 2023 - 216 p.

Source: Dissertations Abstracts International, Volume: 85-01, Section: B.

Thesis (Ph.D.)--Icahn School of Medicine at Mount Sinai, 2023.

Drugs with unexpected and severe toxicities cause immense risk to patients. Many strategies, both experimental and computational, have been devised to anticipate and understand the undesirable effects of compounds on the body. Even with these tools however, many drugs still exhibit intolerable safety profiles in human testing and long-term use within the population. It is clear that additional strategies are still needed to accurately predict drug toxicity. A promising approach to addressing the challenge of drug toxicity prediction, which this thesis illustrates, incorporates protein structure-based data with machine learning techniques. Structural features have previously demonstrated their utility for revealing patterns in many biological phenomena such as protein-protein interactions and genetic disease protein networks. This thesis presents a tool that determines structural features and, in combination with machine learning approaches, predicts trends in human tissue identity, cancer classification, as well as drug toxicity.This thesis describes a standardized method for generating protein structural features in part I and applies this tool, along with feature selection and ensemble learning, to address the challenge of drug toxicity prediction in part II. Due to the myriad levels of severity and types of toxicity, labeling a drug with a toxicity status is a non-trivial task. Therefore, this thesis incorporates the toxicity evaluation of drugs as determined by regulatory bodies of experts such as the FDA. Drug withdrawal from the market is thus treated an indication of severe or intolerable drug toxicity. Characteristics of compounds with severe toxicity are compared to those of drugs, which are still available on the market using a variety of feature selection techniques. These approaches look for variability in underlying features between the two groups and determine ranges of expected values for these characteristics. The insights encompassed in this work generate guidelines for drug toxicity assessment during the drug development process. Further advances are made to the field of toxicity prediction with the development of a drug toxicity classification ensemble algorithm trained on drug target features as well as drug chemical features. This tool predicts the likelihood of withdrawal from the market of compounds currently under investigation in clinical trials. The structural feature generation tool, the web server, and the machine learning based characterization of toxic drugs have a variety of applications, particularly in drug development.

ISBN: 9798379796013Subjects--Topical Terms:

3350019
Computational chemistry.
Subjects--Index Terms:

Clinical trials

Integrating Machine Learning and Protein Structural Features to Predict Drug Toxicity.
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