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Comparative Differentially Expressed...

Wood, Rozalyn R.

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Comparative Differentially Expressed Gene Signals of Patients With Major Depressive Disorder and Patients Taking Antidepressant Medications Using Living Brain Tissue: An Extension of the Living Brain Project.

紀錄類型:	書目-電子資源 : Monograph/item
正題名/作者:	Comparative Differentially Expressed Gene Signals of Patients With Major Depressive Disorder and Patients Taking Antidepressant Medications Using Living Brain Tissue: An Extension of the Living Brain Project./
作者:	Wood, Rozalyn R.
出版者:	Ann Arbor : ProQuest Dissertations & Theses, : 2023,
面頁冊數:	57 p.
附註:	Source: Masters Abstracts International, Volume: 84-12.
Contained By:	Masters Abstracts International84-12.
標題:	Neurosciences. -
電子資源:	https://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=30527648
ISBN:	9798379702670

Comparative Differentially Expressed Gene Signals of Patients With Major Depressive Disorder and Patients Taking Antidepressant Medications Using Living Brain Tissue: An Extension of the Living Brain Project.
Wood, Rozalyn R.

Comparative Differentially Expressed Gene Signals of Patients With Major Depressive Disorder and Patients Taking Antidepressant Medications Using Living Brain Tissue: An Extension of the Living Brain Project. - Ann Arbor : ProQuest Dissertations & Theses, 2023 - 57 p.

Source: Masters Abstracts International, Volume: 84-12.

Thesis (M.S.)--Icahn School of Medicine at Mount Sinai, 2023.

Major depressive disorder (MDD) is a complex psychiatric trait often treated with antidepressant medications. Previous gene expression studies on depression and antidepressant treatment outcome often utilize postmortem brain tissue or peripheral blood. In this novel study design, biopsied living brain tissue from consenting patients receiving clinically relevant deep brain stimulation is sequenced for future research. Using the living brain tissue, this current study aims to compare the differentially expressed gene (DEG) signals between patients with depression and patients taking antidepressants medications. Once characterized by their electronic health records, differential expression analysis and gene enrichment analysis were conducted for both cohorts. A robust DEG signal (π1 = 0.5797, adjusted p-value<0.05) was determined in patients taking antidepressants but not in patients with MDD. Gene ontology analysis indicates enrichment in the immune system, signaling/cell processes and nervous system. These findings extend previous literature findings on DEG and gene enrichment for antidepressant treatment outcome.

ISBN: 9798379702670Subjects--Topical Terms:

588700
Neurosciences.
Subjects--Index Terms:

Antidepressants

Comparative Differentially Expressed Gene Signals of Patients With Major Depressive Disorder and Patients Taking Antidepressant Medications Using Living Brain Tissue: An Extension of the Living Brain Project.
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