東華大學圖書館 |

Language: English

Help

回圖書館首頁

手機版館藏查詢

Back to Search results for [ null ]

Switch To: Labeled | MARC Mode | ISBD

Cell toxicity and uptake of RRR-alph...

Komguem Kamga, Christelle.

Linked to FindBook

Google Book

Amazon

博客來

Cell toxicity and uptake of RRR-alpha-tocopheryl polyethylene glycol 1000 succinate (TPGS) by various cell lines in vitro.

Record Type:	Electronic resources : Monograph/item
Title/Author:	Cell toxicity and uptake of RRR-alpha-tocopheryl polyethylene glycol 1000 succinate (TPGS) by various cell lines in vitro./
Author:	Komguem Kamga, Christelle.
Published:	Ann Arbor : ProQuest Dissertations & Theses, : 2005,
Description:	78 p.
Notes:	Source: Masters Abstracts International, Volume: 70-05.
Contained By:	Masters Abstracts International70-05.
Subject:	Analytical chemistry. -
Online resource:	https://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=1458316
ISBN:	9780549758068

Cell toxicity and uptake of RRR-alpha-tocopheryl polyethylene glycol 1000 succinate (TPGS) by various cell lines in vitro.
Komguem Kamga, Christelle.

Cell toxicity and uptake of RRR-alpha-tocopheryl polyethylene glycol 1000 succinate (TPGS) by various cell lines in vitro. - Ann Arbor : ProQuest Dissertations & Theses, 2005 - 78 p.

Source: Masters Abstracts International, Volume: 70-05.

Thesis (M.Sc.)--East Tennessee State University, 2005.

This research focused on investigating and comparing the cytotoxicity and cellular uptake of RRR-alpha-tocopheryl polyethylene glycol succinate (TPGS) with that of alpha-tocopheryl succinate (α-TS). Both TPGS and α-TS are water-soluble forms of vitamin E with important clinical applications. Cytotoxicity assays with RAW 264.7 and LNCaP cells incubated overnight with TPGS or α-TS at concentrations ≥ 12.4 μM suggest that α-TS is more cytotoxic than TPGS. Macrophages were found to be more sensitive than LNCaP cells when treated with similar concentrations of α-TS. For both cell lines, most of the TPGS or α-TS taken up remained esterified after 24 hours. Our results suggest that cell death was due to TPGS and/or α-TS and not alpha-tocopherol. A para-hydroxyanilide of α-TS (p-HATS) that could be used to distinguish between cellular TPGS and α-TS was studied. It was found that p-HATS can be detected electrochemically and that it is hydrolyzed to α-TOH.

ISBN: 9780549758068Subjects--Topical Terms:

3168300
Analytical chemistry.

Cell toxicity and uptake of RRR-alpha-tocopheryl polyethylene glycol 1000 succinate (TPGS) by various cell lines in vitro.
LDR:02040nmm a2200337 4500 001 2399847
005 20240916065958.5
006 m o d
007 cr#unu||||||||
008 251215s2005 ||||||||||||||||| ||eng d
020 $a 9780549758068
035 $a (MiAaPQ)AAI1458316
035 $a AAI1458316
040 $a MiAaPQ $c MiAaPQ
100 1 $a Komguem Kamga, Christelle. $3 3769821
245 1 0 $a Cell toxicity and uptake of RRR-alpha-tocopheryl polyethylene glycol 1000 succinate (TPGS) by various cell lines in vitro.
260 1 $a Ann Arbor : $b ProQuest Dissertations & Theses, $c 2005
300 $a 78 p.
500 $a Source: Masters Abstracts International, Volume: 70-05.
500 $a Publisher info.: Dissertation/Thesis.
500 $a Advisor: Stone, William L.
502 $a Thesis (M.Sc.)--East Tennessee State University, 2005.
520 $a This research focused on investigating and comparing the cytotoxicity and cellular uptake of RRR-alpha-tocopheryl polyethylene glycol succinate (TPGS) with that of alpha-tocopheryl succinate (α-TS). Both TPGS and α-TS are water-soluble forms of vitamin E with important clinical applications. Cytotoxicity assays with RAW 264.7 and LNCaP cells incubated overnight with TPGS or α-TS at concentrations ≥ 12.4 μM suggest that α-TS is more cytotoxic than TPGS. Macrophages were found to be more sensitive than LNCaP cells when treated with similar concentrations of α-TS. For both cell lines, most of the TPGS or α-TS taken up remained esterified after 24 hours. Our results suggest that cell death was due to TPGS and/or α-TS and not alpha-tocopherol. A para-hydroxyanilide of α-TS (p-HATS) that could be used to distinguish between cellular TPGS and α-TS was studied. It was found that p-HATS can be detected electrochemically and that it is hydrolyzed to α-TOH.
590 $a School code: 0069.
650 4 $a Analytical chemistry. $3 3168300
650 4 $a Biochemistry. $3 518028
650 4 $a Physical chemistry. $3 1981412
690 $a 0486
690 $a 0487
690 $a 0494
710 2 $a East Tennessee State University. $3 1017802
773 0 $t Masters Abstracts International $g 70-05.
790 $a 0069
791 $a M.Sc.
792 $a 2005
793 $a English
856 4 0 $u https://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=1458316