東華大學圖書館 |

語系: 繁體中文

說明(常見問題)

回圖書館首頁

手機版館藏查詢

登入

回首頁 到查詢結果 [ null ]

切換: 標籤 | MARC模式 | ISBD

Metal-Organic Nanosensitizers for Dr...

Luo, Taokun,

FindBook

Google Book

Amazon

博客來

Metal-Organic Nanosensitizers for Drug Delivery and Cancer Therapy /

紀錄類型:	書目-電子資源 : Monograph/item
正題名/作者:	Metal-Organic Nanosensitizers for Drug Delivery and Cancer Therapy // Taokun Luo.
作者:	Luo, Taokun,
面頁冊數:	1 electronic resource (263 pages)
附註:	Source: Dissertations Abstracts International, Volume: 85-02, Section: B.
Contained By:	Dissertations Abstracts International85-02B.
標題:	Inorganic chemistry. -
電子資源:	https://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=30568269
ISBN:	9798380143608

Metal-Organic Nanosensitizers for Drug Delivery and Cancer Therapy /
Luo, Taokun,

Metal-Organic Nanosensitizers for Drug Delivery and Cancer Therapy /Taokun Luo. - 1 electronic resource (263 pages)

Source: Dissertations Abstracts International, Volume: 85-02, Section: B.

Metal-organic nanosensitizers (MONs), including nanoscale metal-organic frameworks (nMOFs) and nanoscale metal-organic layers (nMOLs), are emerging nanoplatforms for biomedical applications, including photodynamic therapy (PDT), radiotherapy-radiodynamic therapy (RT-RDT), immunotherapy, sonodynamic therapy, photothermal therapy (PTT), drug delivery, imaging, and sensing. MON is a crystalline, porous, and supramolecular material consisting of bridging organic molecules (ligands) and metal or metal-oxo nodes (primary or secondary building units). MONs can achieve efficient mass transport for drug delivery and energy transfer to sensitize the generation of reactive oxygen species (ROS), respectively. Because of the component hierarchy in MONs, we can incorporate photosensitizing molecules into the ligands for PDT or stabilize unstable drugs by framework rigidity. We can use heavy metals in the secondary building units (SBUs) to enhance radiotherapy (RT) or conjugate hydrophilic drugs to SBUs for a sustained release under physiological conditions. The insoluble, hydrophobic drugs can be loaded into the hydrophobic channels of MOFs for delivery or spatial isolation to avoid aggregation-induced quenching of photosensitizers (PSs).The research of MONs for drug delivery and cancer therapy is a cross-disciplinary research standing at the intersection of physics, chemistry, and biology. Physics is used to study the energy transfer and sensitization mechanisms as exemplified by how low-energy or high-energy photons interact with photosensitizers or heavy metal SBUs, respectively. Chemistry is used to efficiently synthesize and characterize MON materials with crystallinity, appropriate pore dimensions, and suitable particle sizes, and to modify MONs with suitable therapeutic motifs. Biology and immunology are used to identify target applications, analyze treatment outcomes, and inform MON optimization for enhanced biological effects.My Ph.D. thesis research further leveraged the properties of MON materials, such as the rigid framework, open channels, Lewis acidic SBUs, and material dimensionality to maximize their anticancer efficacy. Starting from molecular design and material engineering, my research interest gradually shifted to the biomedical applications of MONs and addressing the limitations of existing anticancer drugs, such as instability, limited water solubility, and poor pharmacokinetics. My graduate research demonstrates MONs as a powerful nanoplatform for rescuing unfavorable drug candidates to enhance cancer therapy, including PDT, RT-RDT, chemotherapy, and immunotherapy.

English

ISBN: 9798380143608Subjects--Topical Terms:

3173556
Inorganic chemistry.
Subjects--Index Terms:

Cancer therapy

Metal-Organic Nanosensitizers for Drug Delivery and Cancer Therapy /
LDR:04053nmm a22004453i 4500 001 2396185
005 20250522083206.5
006 m o d
007 cr|nu||||||||
008 251215s2023 miu||||||m |||||||eng d
020 $a 9798380143608
035 $a (MiAaPQD)AAI30568269
035 $a AAI30568269
040 $a MiAaPQD $b eng $c MiAaPQD $e rda
100 1 $a Luo, Taokun, $e author. $0 (orcid)0000-0001-5894-0490 $3 3765803
245 1 0 $a Metal-Organic Nanosensitizers for Drug Delivery and Cancer Therapy / $c Taokun Luo.
264 1 $a Ann Arbor : $b ProQuest Dissertations & Theses, $c 2023
300 $a 1 electronic resource (263 pages)
336 $a text $b txt $2 rdacontent
337 $a computer $b c $2 rdamedia
338 $a online resource $b cr $2 rdacarrier
500 $a Source: Dissertations Abstracts International, Volume: 85-02, Section: B.
500 $a Advisors: Lin, Wenbin Committee members: He, Chuan; Kron, Stephen.
502 $b Ph.D. $c The University of Chicago $d 2023.
520 $a Metal-organic nanosensitizers (MONs), including nanoscale metal-organic frameworks (nMOFs) and nanoscale metal-organic layers (nMOLs), are emerging nanoplatforms for biomedical applications, including photodynamic therapy (PDT), radiotherapy-radiodynamic therapy (RT-RDT), immunotherapy, sonodynamic therapy, photothermal therapy (PTT), drug delivery, imaging, and sensing. MON is a crystalline, porous, and supramolecular material consisting of bridging organic molecules (ligands) and metal or metal-oxo nodes (primary or secondary building units). MONs can achieve efficient mass transport for drug delivery and energy transfer to sensitize the generation of reactive oxygen species (ROS), respectively. Because of the component hierarchy in MONs, we can incorporate photosensitizing molecules into the ligands for PDT or stabilize unstable drugs by framework rigidity. We can use heavy metals in the secondary building units (SBUs) to enhance radiotherapy (RT) or conjugate hydrophilic drugs to SBUs for a sustained release under physiological conditions. The insoluble, hydrophobic drugs can be loaded into the hydrophobic channels of MOFs for delivery or spatial isolation to avoid aggregation-induced quenching of photosensitizers (PSs).The research of MONs for drug delivery and cancer therapy is a cross-disciplinary research standing at the intersection of physics, chemistry, and biology. Physics is used to study the energy transfer and sensitization mechanisms as exemplified by how low-energy or high-energy photons interact with photosensitizers or heavy metal SBUs, respectively. Chemistry is used to efficiently synthesize and characterize MON materials with crystallinity, appropriate pore dimensions, and suitable particle sizes, and to modify MONs with suitable therapeutic motifs. Biology and immunology are used to identify target applications, analyze treatment outcomes, and inform MON optimization for enhanced biological effects.My Ph.D. thesis research further leveraged the properties of MON materials, such as the rigid framework, open channels, Lewis acidic SBUs, and material dimensionality to maximize their anticancer efficacy. Starting from molecular design and material engineering, my research interest gradually shifted to the biomedical applications of MONs and addressing the limitations of existing anticancer drugs, such as instability, limited water solubility, and poor pharmacokinetics. My graduate research demonstrates MONs as a powerful nanoplatform for rescuing unfavorable drug candidates to enhance cancer therapy, including PDT, RT-RDT, chemotherapy, and immunotherapy.
546 $a English
590 $a School code: 0330
650 4 $a Inorganic chemistry. $3 3173556
650 4 $a Biochemistry. $3 518028
650 4 $a Oncology. $3 751006
653 $a Cancer therapy
653 $a Chemotherapy
653 $a Immunotherapy
653 $a Metal-organic framework
653 $a Photodynamic therapy
653 $a Radiotherapy
690 $a 0488
690 $a 0487
690 $a 0992
710 2 $a The University of Chicago. $b Chemistry. $e degree granting institution. $3 3765804
720 1 $a Lin, Wenbin $e degree supervisor.
773 0 $t Dissertations Abstracts International $g 85-02B.
790 $a 0330
791 $a Ph.D.
792 $a 2023
856 4 0 $u https://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=30568269