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Guo, Bing,

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Organic Nanomaterials for Photoacoustic Imaging and Photothermal Therapy /

Record Type:	Electronic resources : Monograph/item
Title/Author:	Organic Nanomaterials for Photoacoustic Imaging and Photothermal Therapy // Bing Guo.
Author:	Guo, Bing,
Description:	1 electronic resource (205 pages)
Notes:	Source: Dissertations Abstracts International, Volume: 80-02, Section: C.
Contained By:	Dissertations Abstracts International80-02C.
Subject:	Biomedical engineering. -
Online resource:	https://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=10907609
ISBN:	9781083491879

Organic Nanomaterials for Photoacoustic Imaging and Photothermal Therapy /
Guo, Bing,

Organic Nanomaterials for Photoacoustic Imaging and Photothermal Therapy /Bing Guo. - 1 electronic resource (205 pages)

Source: Dissertations Abstracts International, Volume: 80-02, Section: C.

This thesis presents molecular guidelines to design the efficient organic photoacoustic imaging (PA) and photothermal therapy (PTT) agents, which are evaluated in vitro and in vivo to demonstrate the proof-of-concepts. Firstly, monomeric porphyrin units are transformed into photostable polymeric backbones, forming a donor-acceptor (D-A) structured conjugated polymer (CP) with red-shifted and significantly enhanced absorption and high photothermal conversion efficiency tumor ablation. Following that, a molecular engineering approach to design CPs with high PA and photothermal performance is illustrated by systematically investigating the relationship between structure and performance. Furthermore, the molecular engineering approach afore-mentioned is applied to design a CP with strong NIR-II absorption, which exhibits much better efficacy than the conventional NIR-I PA agents. In addition, an aggregation-induced emission (AIE) molecule with strong absorptivity and ultrabright emissive capability in solid states is designed for synergetic targeted NIR-II fluorescence and NIR-I PA imaging of brain tumors.

English

ISBN: 9781083491879Subjects--Topical Terms:

535387
Biomedical engineering.
Subjects--Index Terms:

Organic conjugated polymers

Organic Nanomaterials for Photoacoustic Imaging and Photothermal Therapy /
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520 $a This thesis presents molecular guidelines to design the efficient organic photoacoustic imaging (PA) and photothermal therapy (PTT) agents, which are evaluated in vitro and in vivo to demonstrate the proof-of-concepts. Firstly, monomeric porphyrin units are transformed into photostable polymeric backbones, forming a donor-acceptor (D-A) structured conjugated polymer (CP) with red-shifted and significantly enhanced absorption and high photothermal conversion efficiency tumor ablation. Following that, a molecular engineering approach to design CPs with high PA and photothermal performance is illustrated by systematically investigating the relationship between structure and performance. Furthermore, the molecular engineering approach afore-mentioned is applied to design a CP with strong NIR-II absorption, which exhibits much better efficacy than the conventional NIR-I PA agents. In addition, an aggregation-induced emission (AIE) molecule with strong absorptivity and ultrabright emissive capability in solid states is designed for synergetic targeted NIR-II fluorescence and NIR-I PA imaging of brain tumors.
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