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The Development of Nanodiamond-Based Drug Delivery Complexes for Treatment and Diagnosis of Oncogene-Specific Hepatocellular Carainoma.

紀錄類型:	書目-電子資源 : Monograph/item
正題名/作者:	The Development of Nanodiamond-Based Drug Delivery Complexes for Treatment and Diagnosis of Oncogene-Specific Hepatocellular Carainoma./
作者:	Wang, Xin.
出版者:	Ann Arbor : ProQuest Dissertations & Theses, : 2017,
面頁冊數:	218 p.
附註:	Source: Dissertations Abstracts International, Volume: 80-02, Section: C.
Contained By:	Dissertations Abstracts International80-02C.
標題:	Pharmacology. -
電子資源:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=10907536
ISBN:	9781083529169

The Development of Nanodiamond-Based Drug Delivery Complexes for Treatment and Diagnosis of Oncogene-Specific Hepatocellular Carainoma.
Wang, Xin.

The Development of Nanodiamond-Based Drug Delivery Complexes for Treatment and Diagnosis of Oncogene-Specific Hepatocellular Carainoma. - Ann Arbor : ProQuest Dissertations & Theses, 2017 - 218 p.

Source: Dissertations Abstracts International, Volume: 80-02, Section: C.

Thesis (Ph.D.)--National University of Singapore (Singapore), 2017.

Hepatocellular carcinoma (HCC) is a common cancer with a high mortality rate. HCC pathogenesis is often driven by specific oncogenes. A number of therapeutic approaches have been developed to target and treat oncogene-driven cancer. Currently, however, there are still no clinically effective treatment options for targeting specific oncogenes in HCC. We hypothesized that nanoparticle drug-delivery could be used to improve delivery of therapeutics against oncogene-specific HCC. As such, we have developed a drug delivery system using nanodiamonds (NDs), for enhanced therapies against HCCs driven by oncogenes of c-Myc and Spalt Like Transcription Factor 4 (SALL4). Overall, nanodiamond-drug complexes showed improved drug delivery and stability. Therapeutic efficacy was also improved compared to the free drugs. Our work demonstrates the potential for nanodiamonds in clinical application for treatment and diagnosis of oncogene-specific hepatocellular carcinoma.

ISBN: 9781083529169Subjects--Topical Terms:

634543
Pharmacology.
Subjects--Index Terms:

Drug delivery

The Development of Nanodiamond-Based Drug Delivery Complexes for Treatment and Diagnosis of Oncogene-Specific Hepatocellular Carainoma.
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500 $a Publisher info.: Dissertation/Thesis.
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502 $a Thesis (Ph.D.)--National University of Singapore (Singapore), 2017.
520 $a Hepatocellular carcinoma (HCC) is a common cancer with a high mortality rate. HCC pathogenesis is often driven by specific oncogenes. A number of therapeutic approaches have been developed to target and treat oncogene-driven cancer. Currently, however, there are still no clinically effective treatment options for targeting specific oncogenes in HCC. We hypothesized that nanoparticle drug-delivery could be used to improve delivery of therapeutics against oncogene-specific HCC. As such, we have developed a drug delivery system using nanodiamonds (NDs), for enhanced therapies against HCCs driven by oncogenes of c-Myc and Spalt Like Transcription Factor 4 (SALL4). Overall, nanodiamond-drug complexes showed improved drug delivery and stability. Therapeutic efficacy was also improved compared to the free drugs. Our work demonstrates the potential for nanodiamonds in clinical application for treatment and diagnosis of oncogene-specific hepatocellular carcinoma.
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