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Immune Polyphony : = Dissecting Coordinated Multicellular Networks of Antiviral Immunity.

Record Type:	Electronic resources : Monograph/item
Title/Author:	Immune Polyphony :/
Reminder of title:	Dissecting Coordinated Multicellular Networks of Antiviral Immunity.
Author:	Wilk, Aaron James.
Description:	1 online resource (330 pages)
Notes:	Source: Dissertations Abstracts International, Volume: 84-04, Section: B.
Contained By:	Dissertations Abstracts International84-04B.
Subject:	Infections. -
Online resource:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=29408071click for full text (PQDT)
ISBN:	9798352655672

Immune Polyphony : = Dissecting Coordinated Multicellular Networks of Antiviral Immunity.
Wilk, Aaron James.

Immune Polyphony :Dissecting Coordinated Multicellular Networks of Antiviral Immunity. - 1 online resource (330 pages)

Source: Dissertations Abstracts International, Volume: 84-04, Section: B.

Thesis (Ph.D.)--Stanford University, 2022.

Includes bibliographical references

Viral diseases remain a major cause of morbidity and mortality worldwide and emerging viral pathogens represent a perennial threat to human health. The rapidity, quality, and duration of the immune response to a viral pathogen is a major determinant of disease outcome in viral disease. This immune response to a viral pathogen involves the activity of multiple cell types with distinct and multifaceted functional roles to mount a response that is appropriate in both time and space. An insufficient response may result in unrestrained viral replication while an overly robust response can result in direct tissue damage. Thus, an effectively regulated antiviral immune response requires complex coordination, communication, and regulation between individual immune cells. We coin the term "immune polyphony" to describe these coordinated multicellular networks -- a reference to musical polyphony where multiple individual voices come together to create harmony.Here we present a framework to study and engineer immune polyphony and apply this framework to dissect the features of well-balanced immune responses in multiple viral diseases. First, we examine immune responses in patients with COVID-19 across the full range of the disease severity spectrum to reveal widespread dysregulation of innate immunity in severe COVID-19. Next, we introduce a novel computational framework for the analysis of cell-cell communication pathways at the resolution of the single-cell. We then apply this methodology to analyze inflammatory networks that distinguish immune responses to pathogenic vs. non-pathogenic lentiviruses. Finally, we describe a technique for bio-orthogonal manipulation of primary immune cells, thus providing a pathway for future efforts to engineer polyphonic immune responses to promote effective antiviral immunity.

Electronic reproduction.
Ann Arbor, Mich. :
ProQuest,
2023

Mode of access: World Wide Web

ISBN: 9798352655672Subjects--Topical Terms:

1621997
Infections.
Index Terms--Genre/Form:

542853
Electronic books.

Immune Polyphony : = Dissecting Coordinated Multicellular Networks of Antiviral Immunity.
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500 $a Source: Dissertations Abstracts International, Volume: 84-04, Section: B.
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500 $a Advisor: Bintu, Lacramioara; Greenleaf, William James; Kim, Peter; Krams, Sheri Michele.
502 $a Thesis (Ph.D.)--Stanford University, 2022.
504 $a Includes bibliographical references
520 $a Viral diseases remain a major cause of morbidity and mortality worldwide and emerging viral pathogens represent a perennial threat to human health. The rapidity, quality, and duration of the immune response to a viral pathogen is a major determinant of disease outcome in viral disease. This immune response to a viral pathogen involves the activity of multiple cell types with distinct and multifaceted functional roles to mount a response that is appropriate in both time and space. An insufficient response may result in unrestrained viral replication while an overly robust response can result in direct tissue damage. Thus, an effectively regulated antiviral immune response requires complex coordination, communication, and regulation between individual immune cells. We coin the term "immune polyphony" to describe these coordinated multicellular networks -- a reference to musical polyphony where multiple individual voices come together to create harmony.Here we present a framework to study and engineer immune polyphony and apply this framework to dissect the features of well-balanced immune responses in multiple viral diseases. First, we examine immune responses in patients with COVID-19 across the full range of the disease severity spectrum to reveal widespread dysregulation of innate immunity in severe COVID-19. Next, we introduce a novel computational framework for the analysis of cell-cell communication pathways at the resolution of the single-cell. We then apply this methodology to analyze inflammatory networks that distinguish immune responses to pathogenic vs. non-pathogenic lentiviruses. Finally, we describe a technique for bio-orthogonal manipulation of primary immune cells, thus providing a pathway for future efforts to engineer polyphonic immune responses to promote effective antiviral immunity.
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