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Discovery of small-molecule compounds targeting TREX1.

紀錄類型:	書目-電子資源 : Monograph/item
Title/Author:	Discovery of small-molecule compounds targeting TREX1./
Author:	Qian, Junjie.
Published:	Ann Arbor : ProQuest Dissertations & Theses, : 2012,
Description:	50 p.
Notes:	Source: Masters Abstracts International, Volume: 74-05.
Contained By:	Masters Abstracts International74-05.
Subject:	Pharmacology. -
Online resource:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=1529049
ISBN:	9781267699541

Discovery of small-molecule compounds targeting TREX1.
Qian, Junjie.

Discovery of small-molecule compounds targeting TREX1. - Ann Arbor : ProQuest Dissertations & Theses, 2012 - 50 p.

Source: Masters Abstracts International, Volume: 74-05.

Thesis (M.S.)--University of Southern California, 2012.

Three prime repair exonuclease 1 (TREX1) plays an important role in human DNA repair. More importantly, it has been recently discovered that the 3'→5' DNA exonucleolytic function of TREX1 helps to hide HIV-1 from human innate immune system by digesting nonproductive HIV-1 DNA in cytosol. This new property of TREX1 makes it a promising therapeutic target for anti-HIV drug development. With the purpose of designing and discovering novel inhibitors to this new promising target, we screened diverse sets of drug-like in-house compounds. In addition, the potentials of active compounds serving as dual inhibitors that not only target to TREX1, but also to HIV integrase (IN) were also analyzed. Ultimately, we identified six promising TREX1-inhibitors belonging to five structural classes.

ISBN: 9781267699541Subjects--Topical Terms:

634543
Pharmacology.
Subjects--Index Terms:

Dual inhibitor

Discovery of small-molecule compounds targeting TREX1.
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