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Genome-wide Study of Emphysema Progression and Gene-by-smoking Interaction of Chronic Obstructive Pulmonary Disease.

紀錄類型:	書目-電子資源 : Monograph/item
正題名/作者:	Genome-wide Study of Emphysema Progression and Gene-by-smoking Interaction of Chronic Obstructive Pulmonary Disease./
作者:	Kim, Woori.
出版者:	Ann Arbor : ProQuest Dissertations & Theses, : 2020,
面頁冊數:	152 p.
附註:	Source: Dissertations Abstracts International, Volume: 82-03, Section: B.
Contained By:	Dissertations Abstracts International82-03B.
標題:	Public health. -
電子資源:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=28068762
ISBN:	9798662429628

Genome-wide Study of Emphysema Progression and Gene-by-smoking Interaction of Chronic Obstructive Pulmonary Disease.
Kim, Woori.

Genome-wide Study of Emphysema Progression and Gene-by-smoking Interaction of Chronic Obstructive Pulmonary Disease. - Ann Arbor : ProQuest Dissertations & Theses, 2020 - 152 p.

Source: Dissertations Abstracts International, Volume: 82-03, Section: B.

Thesis (Ph.D.)--The Johns Hopkins University, 2020.

This item must not be sold to any third party vendors.

Chronic Obstructive Pulmonary Disease (COPD) is a progressive respiratory disease characterized by airflow limitation, an impairment of lung function. Emphysema is a major pathological change of COPD and characterized by the destruction of lung parenchyma. COPD is the third leading cause of death worldwide. The primary environmental risk factor for COPD is cigarette smoking, but individuals vary in their susceptibility to the effects of cigarette smoke and only a minority of smokers will ever develop COPD. This indicates other factors besides smoking are involved in the development and progression of COPD, and these may interact with smoking. This dissertation investigates the genetic determinants of emphysema progression quantified by computed tomography (CT) imaging and studies gene-by-smoking interaction on COPD risk 1) at the genome-wide scale and 2) using a polygenic risk score approach. This dissertation uses data from the COPDGene and ECLIPSE study, a longitudinal cohort of current and former smokers measuring chest CT scan, and the UK Biobank, a large-scale cohort recruiting over 500,000 volunteers throughout the United Kingdom.

ISBN: 9798662429628Subjects--Topical Terms:

534748
Public health.
Subjects--Index Terms:

Genetic epidemiology

Genome-wide Study of Emphysema Progression and Gene-by-smoking Interaction of Chronic Obstructive Pulmonary Disease.
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