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Proteogenomics Tools and Their Appli...

Kawaler, Emily A.

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Proteogenomics Tools and Their Applications in the Molecular Characterization of Cancer.

Record Type:	Electronic resources : Monograph/item
Title/Author:	Proteogenomics Tools and Their Applications in the Molecular Characterization of Cancer./
Author:	Kawaler, Emily A.
Published:	Ann Arbor : ProQuest Dissertations & Theses, : 2021,
Description:	189 p.
Notes:	Source: Dissertations Abstracts International, Volume: 83-02, Section: B.
Contained By:	Dissertations Abstracts International83-02B.
Subject:	Bioinformatics. -
Online resource:	https://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=28410343
ISBN:	9798534690200

Proteogenomics Tools and Their Applications in the Molecular Characterization of Cancer.
Kawaler, Emily A.

Proteogenomics Tools and Their Applications in the Molecular Characterization of Cancer. - Ann Arbor : ProQuest Dissertations & Theses, 2021 - 189 p.

Source: Dissertations Abstracts International, Volume: 83-02, Section: B.

Thesis (Ph.D.)--New York University, 2021.

This item must not be sold to any third party vendors.

Although cancer is commonly thought of as a disease of the genome, the genomic aberrations that give rise to cancerous tissue are only a small part of the cancer pathology. To draw a complete picture of the molecular characteristics that define cancer, it is vital to thoroughly investigate the proteome as well. Unfortunately, describing the proteome is a much more difficult task, requiring customized algorithms and software tools that take advantage of not only proteomics technologies but also the less expensive and more advanced genomics and transcriptomics technologies. In the following pages, I present two software tools for the proteogenomic analysis of cancerous tissue: Black Sheep, a software package for differential extreme value analysis that is particularly well suited to the challenges of phosphoproteomics; and QUILTS, a sample-specific variant database generation tool that enables the detection of variant peptides in tandem mass spectrometry output. I show how these and other proteogenomics tools can be applied to solve urgent clinical problems; first, by detailing the work my colleagues and I undertook to produce a comprehensive molecular characterization of endometrial cancer; and second, by describing our analysis of the pan-cancer variant proteome.

ISBN: 9798534690200Subjects--Topical Terms:

553671
Bioinformatics.
Subjects--Index Terms:

Proteogenomics tools

Proteogenomics Tools and Their Applications in the Molecular Characterization of Cancer.
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