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Estimates of Spiral Ganglion Neuron ...

Jahn, Kelly N.

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Estimates of Spiral Ganglion Neuron Health in Children and Adults with Cochlear Implants.

Record Type:	Electronic resources : Monograph/item
Title/Author:	Estimates of Spiral Ganglion Neuron Health in Children and Adults with Cochlear Implants./
Author:	Jahn, Kelly N.
Published:	Ann Arbor : ProQuest Dissertations & Theses, : 2019,
Description:	187 p.
Notes:	Source: Dissertations Abstracts International, Volume: 81-03, Section: B.
Contained By:	Dissertations Abstracts International81-03B.
Subject:	Audiology. -
Online resource:	https://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=13858447
ISBN:	9781085710510

Estimates of Spiral Ganglion Neuron Health in Children and Adults with Cochlear Implants.
Jahn, Kelly N.

Estimates of Spiral Ganglion Neuron Health in Children and Adults with Cochlear Implants. - Ann Arbor : ProQuest Dissertations & Theses, 2019 - 187 p.

Source: Dissertations Abstracts International, Volume: 81-03, Section: B.

Thesis (Ph.D.)--University of Washington, 2019.

This item is not available from ProQuest Dissertations & Theses.

Cochlear implants (CIs) can improve auditory perception for children and adults with severe to profound hearing loss, but little is known about how to optimize clinical interventions for individual patients. In fact, children and adults receive largely the same CI programming strategies despite their divergent hearing histories and auditory needs. Since CIs are designed to interface directly with the auditory nerve, knowledge of the physiological integrity of the spiral ganglion neurons (SGNs) may assist in developing patient-specific programming recommendations for children and adults. A series of experiments was conducted to quantify various aspects of SGN health in children and adults with CIs. Using the electrically evoked compound action potential (ECAP), the first two experiments determined whether local (within-ear) or global (across-ear) estimates of SGN density differ between child-implanted and adult-implanted listeners. A third experiment assessed the validity of using polarity sensitivity to infer the health of the peripheral processes in CI listeners, and a fourth experiment determined whether polarity sensitivity differed between children and adults with CIs. The results of these experiments suggested that young CI listeners who were deafened and implanted during childhood likely have denser populations of viable SGNs than older, adult-implanted listeners. However, deaf individuals may experience some degree of peripheral process degeneration regardless of their hearing history. The knowledge gained from these experiments suggests that optimal CI programming strategies may differ for children and adults. The results of this dissertation provide several avenues for future investigation of individualized programming parameters in listeners with diverse hearing histories.

ISBN: 9781085710510Subjects--Topical Terms:

537237
Audiology.
Subjects--Index Terms:

Auditory nerve

Estimates of Spiral Ganglion Neuron Health in Children and Adults with Cochlear Implants.
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245 1 0 $a Estimates of Spiral Ganglion Neuron Health in Children and Adults with Cochlear Implants.
260 1 $a Ann Arbor : $b ProQuest Dissertations & Theses, $c 2019
300 $a 187 p.
500 $a Source: Dissertations Abstracts International, Volume: 81-03, Section: B.
500 $a Advisor: Tremblay, Kelly;Arenberg, Julie .
502 $a Thesis (Ph.D.)--University of Washington, 2019.
506 $a This item is not available from ProQuest Dissertations & Theses.
506 $a This item must not be sold to any third party vendors.
506 $a This item must not be added to any third party search indexes.
520 $a Cochlear implants (CIs) can improve auditory perception for children and adults with severe to profound hearing loss, but little is known about how to optimize clinical interventions for individual patients. In fact, children and adults receive largely the same CI programming strategies despite their divergent hearing histories and auditory needs. Since CIs are designed to interface directly with the auditory nerve, knowledge of the physiological integrity of the spiral ganglion neurons (SGNs) may assist in developing patient-specific programming recommendations for children and adults. A series of experiments was conducted to quantify various aspects of SGN health in children and adults with CIs. Using the electrically evoked compound action potential (ECAP), the first two experiments determined whether local (within-ear) or global (across-ear) estimates of SGN density differ between child-implanted and adult-implanted listeners. A third experiment assessed the validity of using polarity sensitivity to infer the health of the peripheral processes in CI listeners, and a fourth experiment determined whether polarity sensitivity differed between children and adults with CIs. The results of these experiments suggested that young CI listeners who were deafened and implanted during childhood likely have denser populations of viable SGNs than older, adult-implanted listeners. However, deaf individuals may experience some degree of peripheral process degeneration regardless of their hearing history. The knowledge gained from these experiments suggests that optimal CI programming strategies may differ for children and adults. The results of this dissertation provide several avenues for future investigation of individualized programming parameters in listeners with diverse hearing histories.
590 $a School code: 0250.
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650 4 $a Neurosciences. $3 588700
653 $a Auditory nerve
653 $a Cochlear implant
653 $a Pediatrics
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710 2 $a University of Washington. $b Speech and Hearing Sciences. $3 3185185
773 0 $t Dissertations Abstracts International $g 81-03B.
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791 $a Ph.D.
792 $a 2019
793 $a English
856 4 0 $u https://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=13858447