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Should We Be Studying Family Communi...

Guo, He.

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Should We Be Studying Family Communication Tools to Improve Cascade Testing in Genomics? A Value-of-Information Analysis in Lynch Syndrome.

Record Type:	Electronic resources : Monograph/item
Title/Author:	Should We Be Studying Family Communication Tools to Improve Cascade Testing in Genomics? A Value-of-Information Analysis in Lynch Syndrome./
Author:	Guo, He.
Published:	Ann Arbor : ProQuest Dissertations & Theses, : 2020,
Description:	21 p.
Notes:	Source: Masters Abstracts International, Volume: 82-04.
Contained By:	Masters Abstracts International82-04.
Subject:	Health sciences. -
Online resource:	https://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=28031558
ISBN:	9798684637957

Should We Be Studying Family Communication Tools to Improve Cascade Testing in Genomics? A Value-of-Information Analysis in Lynch Syndrome.
Guo, He.

Should We Be Studying Family Communication Tools to Improve Cascade Testing in Genomics? A Value-of-Information Analysis in Lynch Syndrome. - Ann Arbor : ProQuest Dissertations & Theses, 2020 - 21 p.

Source: Masters Abstracts International, Volume: 82-04.

Thesis (Master's)--University of Washington, 2020.

This item must not be sold to any third party vendors.

Purpose: To estimate the potential value of family communication tools to improve cascade screening in Lynch syndrome and the expected value of additional research to reduce uncertainty in their effectiveness.Methods: We developed a decision tree and Markov model, which consists of four states: well, colorectal cancer (CRC) (year 1), CRC (years 2-5+) and death. A preliminary estimate of the effectiveness of a communication tool was based on a pilot RCT of a tool we previously developed, FamilyTalk. Clinical probabilities, utilities, and costs were derived from published literature and secondary databases. Value-of-information (VOI) analysis was used to estimate the expected value of additional evidence generated from future research.Results: The communication tool led to a difference in costs ranging from-

ISBN: 9798684637957Subjects--Topical Terms:

3168359
Health sciences.
Subjects--Index Terms:

Cost effectiveness analysis

Should We Be Studying Family Communication Tools to Improve Cascade Testing in Genomics? A Value-of-Information Analysis in Lynch Syndrome.
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245 1 0 $a Should We Be Studying Family Communication Tools to Improve Cascade Testing in Genomics? A Value-of-Information Analysis in Lynch Syndrome.
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300 $a 21 p.
500 $a Source: Masters Abstracts International, Volume: 82-04.
500 $a Advisor: Veenstra, David.
502 $a Thesis (Master's)--University of Washington, 2020.
506 $a This item must not be sold to any third party vendors.
520 $a Purpose: To estimate the potential value of family communication tools to improve cascade screening in Lynch syndrome and the expected value of additional research to reduce uncertainty in their effectiveness.Methods: We developed a decision tree and Markov model, which consists of four states: well, colorectal cancer (CRC) (year 1), CRC (years 2-5+) and death. A preliminary estimate of the effectiveness of a communication tool was based on a pilot RCT of a tool we previously developed, FamilyTalk. Clinical probabilities, utilities, and costs were derived from published literature and secondary databases. Value-of-information (VOI) analysis was used to estimate the expected value of additional evidence generated from future research.Results: The communication tool led to a difference in costs ranging from- $1 ,608 to $4,632 and a difference in quality-adjusted life-years (QALYs) from-0.26 to 0.83. The estimated value of future research specifically on the effectiveness of a communication tool was $52 million. In contrast, further research on reducing the uncertainties of adherence to or effectiveness of annual colonoscopy did not contribute to decreased decision uncertainty.Conclusion: A family communication tool to improve Lynch syndrome cascade screening of even moderate effectiveness likely provides good economic value, but further research is warranted.
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653 $a Value of information
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