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Olfactory and Multisensory Spatial M...

Radvansky, Brad Allen.

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Olfactory and Multisensory Spatial Mapping of the Hippocampus in Virtual Reality.

Record Type:	Electronic resources : Monograph/item
Title/Author:	Olfactory and Multisensory Spatial Mapping of the Hippocampus in Virtual Reality./
Author:	Radvansky, Brad Allen.
Published:	Ann Arbor : ProQuest Dissertations & Theses, : 2020,
Description:	250 p.
Notes:	Source: Dissertations Abstracts International, Volume: 82-06, Section: B.
Contained By:	Dissertations Abstracts International82-06B.
Subject:	Neurosciences. -
Online resource:	https://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=28093579
ISBN:	9798698574538

Olfactory and Multisensory Spatial Mapping of the Hippocampus in Virtual Reality.
Radvansky, Brad Allen.

Olfactory and Multisensory Spatial Mapping of the Hippocampus in Virtual Reality. - Ann Arbor : ProQuest Dissertations & Theses, 2020 - 250 p.

Source: Dissertations Abstracts International, Volume: 82-06, Section: B.

Thesis (Ph.D.)--Northwestern University, 2020.

This item must not be sold to any third party vendors.

Navigating through the world is typically a multisensory experience. Mammals are believed to navigate using a cognitive map of space stored in the hippocampus. Yet, it is unclear how and whether spatial information of different sensory modalities can contribute to this map. A major barrier to addressing this question has been the technical challenge of precisely controlling non-visual spatial cues during navigation. To overcome this challenge, we establish a system to generate and maintain olfactory landscapes in virtual reality. We demonstrate that head-fixed mice can navigate these olfactory virtual landscapes in darkness. This behavior engages hippocampal neurons that tile the olfactory landscape, demonstrating that odor spatial cues alone are sufficient to engage a cognitive map. We next synchronize this system with visual virtual reality and establish three separate behaviors for visual-guided, olfactory-guided, and multisensory-guided navigation through multisensory virtual reality. These behaviors engage visuo-, olfacto-, and (importantly) multisensory-spatially selective hippocampal neurons. The proportions of these neurons and the population-level representation of each sensory coordinate depends on the type of task performed. Thus, the cognitive map can incorporate different sensory modalities flexibly depending on behavioral relevance, and can integrate modalities to map multisensory spaces that have value. These results demonstrate that, from the brain's perspective "space" is not one coherent variable, but a combination of many different physical and abstract reference frames.

ISBN: 9798698574538Subjects--Topical Terms:

588700
Neurosciences.
Subjects--Index Terms:

2-photon calcium imaging

Olfactory and Multisensory Spatial Mapping of the Hippocampus in Virtual Reality.
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245 1 0 $a Olfactory and Multisensory Spatial Mapping of the Hippocampus in Virtual Reality.
260 1 $a Ann Arbor : $b ProQuest Dissertations & Theses, $c 2020
300 $a 250 p.
500 $a Source: Dissertations Abstracts International, Volume: 82-06, Section: B.
500 $a Advisor: Dombeck, Daniel A.
502 $a Thesis (Ph.D.)--Northwestern University, 2020.
506 $a This item must not be sold to any third party vendors.
520 $a Navigating through the world is typically a multisensory experience. Mammals are believed to navigate using a cognitive map of space stored in the hippocampus. Yet, it is unclear how and whether spatial information of different sensory modalities can contribute to this map. A major barrier to addressing this question has been the technical challenge of precisely controlling non-visual spatial cues during navigation. To overcome this challenge, we establish a system to generate and maintain olfactory landscapes in virtual reality. We demonstrate that head-fixed mice can navigate these olfactory virtual landscapes in darkness. This behavior engages hippocampal neurons that tile the olfactory landscape, demonstrating that odor spatial cues alone are sufficient to engage a cognitive map. We next synchronize this system with visual virtual reality and establish three separate behaviors for visual-guided, olfactory-guided, and multisensory-guided navigation through multisensory virtual reality. These behaviors engage visuo-, olfacto-, and (importantly) multisensory-spatially selective hippocampal neurons. The proportions of these neurons and the population-level representation of each sensory coordinate depends on the type of task performed. Thus, the cognitive map can incorporate different sensory modalities flexibly depending on behavioral relevance, and can integrate modalities to map multisensory spaces that have value. These results demonstrate that, from the brain's perspective "space" is not one coherent variable, but a combination of many different physical and abstract reference frames.
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653 $a Olfaction
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