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Development of Patient Based 3D Prin...

Senko, Jillian L.

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Development of Patient Based 3D Printed Cardiac Mitral Valve Phantoms.

Record Type:	Electronic resources : Monograph/item
Title/Author:	Development of Patient Based 3D Printed Cardiac Mitral Valve Phantoms./
Author:	Senko, Jillian L.
Published:	Ann Arbor : ProQuest Dissertations & Theses, : 2020,
Description:	91 p.
Notes:	Source: Masters Abstracts International, Volume: 81-09.
Contained By:	Masters Abstracts International81-09.
Subject:	Biomedical engineering. -
Online resource:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=27736390
ISBN:	9781658421263

Development of Patient Based 3D Printed Cardiac Mitral Valve Phantoms.
Senko, Jillian L.

Development of Patient Based 3D Printed Cardiac Mitral Valve Phantoms. - Ann Arbor : ProQuest Dissertations & Theses, 2020 - 91 p.

Source: Masters Abstracts International, Volume: 81-09.

Thesis (M.S.)--State University of New York at Buffalo, 2020.

This item must not be sold to any third party vendors.

Currently, there is no satisfactory in-vitro mitral valve (MV) three-dimensional (3D) model able to represent accurately the chordae tendineae motion in a hemodynamic simulation. We propose to develop a method to design, 3D print, and post process a mitral valve phantom with all subvalvular structures embedded inside a left heart cardiac phantom. To achieve this, we needed to develop new approaches, which will address the current challenges associated with patient imaging and segmentation of MV, 3D printing of fine elastic structures, and post-printing support material removal from intricate structures. To develop the MV cardiac phantom we used ECG gated cardiac computed tomography (CT) scans to segment structures such as the annulus, leaflets, papillary muscles, left atrium, and left ventricle. Since fine structures are blurred out due to cardiac motion, we used interpolation methods to render the chordae tendineae and attach the chordae to the relevant topology on the underside of the leaflets in compliance with reported diameters and count of chordae from autopsied cadaver hearts. The 3D modified MV was embedded into patient specific cardiac chambers to develop a flow phantom to be tested under hemodynamic simulations. Iterations of the phantom were 3D printed on a Stratasys J750 Digital Anatomy Printer and an Objet Eden 260V 3D printer in various elastic and support materials. Post print support material required 5 to 9-day continuous agitation in basic sodium hydroxide (NaOH) baths to gradually dissolve support and preserve the delicate chordae. The geometry of the systolic, closed, state MV cardiac phantom showed relevant leaflet movement. Our method of phantom design, 3D printing, and post print processing utilizes non-conventional design tactics and elastic 3D printed materials to generate a phantom that closely resembles the mitral valve chordae and shows initial promise to function in a hemodynamic environment.

ISBN: 9781658421263Subjects--Topical Terms:

535387
Biomedical engineering.
Subjects--Index Terms:

3D printing

Development of Patient Based 3D Printed Cardiac Mitral Valve Phantoms.
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500 $a Source: Masters Abstracts International, Volume: 81-09.
500 $a Advisor: Ionita, Ciprian N.
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506 $a This item must not be sold to any third party vendors.
506 $a This item must not be sold to any third party vendors.
520 $a Currently, there is no satisfactory in-vitro mitral valve (MV) three-dimensional (3D) model able to represent accurately the chordae tendineae motion in a hemodynamic simulation. We propose to develop a method to design, 3D print, and post process a mitral valve phantom with all subvalvular structures embedded inside a left heart cardiac phantom. To achieve this, we needed to develop new approaches, which will address the current challenges associated with patient imaging and segmentation of MV, 3D printing of fine elastic structures, and post-printing support material removal from intricate structures. To develop the MV cardiac phantom we used ECG gated cardiac computed tomography (CT) scans to segment structures such as the annulus, leaflets, papillary muscles, left atrium, and left ventricle. Since fine structures are blurred out due to cardiac motion, we used interpolation methods to render the chordae tendineae and attach the chordae to the relevant topology on the underside of the leaflets in compliance with reported diameters and count of chordae from autopsied cadaver hearts. The 3D modified MV was embedded into patient specific cardiac chambers to develop a flow phantom to be tested under hemodynamic simulations. Iterations of the phantom were 3D printed on a Stratasys J750 Digital Anatomy Printer and an Objet Eden 260V 3D printer in various elastic and support materials. Post print support material required 5 to 9-day continuous agitation in basic sodium hydroxide (NaOH) baths to gradually dissolve support and preserve the delicate chordae. The geometry of the systolic, closed, state MV cardiac phantom showed relevant leaflet movement. Our method of phantom design, 3D printing, and post print processing utilizes non-conventional design tactics and elastic 3D printed materials to generate a phantom that closely resembles the mitral valve chordae and shows initial promise to function in a hemodynamic environment.
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