東華大學圖書館 |

語系: 繁體中文

說明(常見問題)

回圖書館首頁

手機版館藏查詢

登入

回首頁 到查詢結果 [ null ]

切換: 標籤 | MARC模式 | ISBD

Psychosocial Stressors, Prescription...

Hu, Yi-Han.

FindBook

Google Book

Amazon

博客來

Psychosocial Stressors, Prescription Drug Use/Misuse, and Risk of Cognitive Impairment Among Middle-aged and Older Adults.

紀錄類型:	書目-電子資源 : Monograph/item
正題名/作者:	Psychosocial Stressors, Prescription Drug Use/Misuse, and Risk of Cognitive Impairment Among Middle-aged and Older Adults./
作者:	Hu, Yi-Han.
出版者:	Ann Arbor : ProQuest Dissertations & Theses, : 2019,
面頁冊數:	136 p.
附註:	Source: Dissertations Abstracts International, Volume: 81-04, Section: A.
Contained By:	Dissertations Abstracts International81-04A.
標題:	Public health. -
電子資源:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=13897529
ISBN:	9781085654821

Psychosocial Stressors, Prescription Drug Use/Misuse, and Risk of Cognitive Impairment Among Middle-aged and Older Adults.
Hu, Yi-Han.

Psychosocial Stressors, Prescription Drug Use/Misuse, and Risk of Cognitive Impairment Among Middle-aged and Older Adults. - Ann Arbor : ProQuest Dissertations & Theses, 2019 - 136 p.

Source: Dissertations Abstracts International, Volume: 81-04, Section: A.

Thesis (Ph.D.)--Indiana University, 2019.

This item must not be sold to any third party vendors.

As the prevalence of dementia increases in the past decades, identifying and reducing risk factors for dementia has grown in importance. Chronic non-cancer pain (CNCP) has been linked to cognitive dysfunction, but the relationships between CNCP and mild cognitive impairment (MCI) and Alzheimer's disease and related diseases (ADRDs) have not been comprehensively studied. In addition, given the accompanying detrimental effects of prescription drug misuse (PDM) on older adults' cognitive function, more information on the determinants of PDM is needed to inform evidence-based interventions. This dissertation consists of three related studies: Study 1 and Study 2 examined the impact of CNCP and pharmacological pain treatments on the risk of developing MCI/ADRD among middle-aged or older adults using an 11-year administrative claims data. Study 3 used a 20-year longitudinal cohort to examine the association of adverse childhood experiences (ACEs) with PDM in middle-aged or older adults, and investigate the mediation effect of adulthood psychosocial stressors.Study 1 revealed that CNCP patients had higher risks for MCI and ADRDs relative to non-CNCP patients. Study 2 found out that opioid use was associated with lower risks of incident MCI/ADRDs. However, a dose-response relationship between cumulative amount of opioid use and risk of ADRDs was found. Study 3 discovered the long-term impact of ACEs on PDM and revealed that the relationship between ACEs and PDM was significant mediated by adulthood psychosocial stressors.Our findings suggest that chronic pain should be carefully and effectively managed by patients and health care providers to reduce MCI and ADRDs risks. Opioid analgesics may alleviate the negative effect of CNCP on cognitive impairment but high dose of opioid should be administrated with cautions when treating CNCP. For individuals with a history of ACEs, early intervention that helps them manage stressful life circumstances in adulthood is needed to prevent PDM in their later life.

ISBN: 9781085654821Subjects--Topical Terms:

534748
Public health.
Subjects--Index Terms:

Adverse childhood experiences

Psychosocial Stressors, Prescription Drug Use/Misuse, and Risk of Cognitive Impairment Among Middle-aged and Older Adults.
LDR:03415nmm a2200457 4500 001 2266633
005 20200612095542.5
008 220629s2019 ||||||||||||||||| ||eng d
020 $a 9781085654821
035 $a (MiAaPQ)AAI13897529
035 $a AAI13897529
040 $a MiAaPQ $c MiAaPQ
100 1 $a Hu, Yi-Han. $3 3543845
245 1 0 $a Psychosocial Stressors, Prescription Drug Use/Misuse, and Risk of Cognitive Impairment Among Middle-aged and Older Adults.
260 1 $a Ann Arbor : $b ProQuest Dissertations & Theses, $c 2019
300 $a 136 p.
500 $a Source: Dissertations Abstracts International, Volume: 81-04, Section: A.
500 $a Advisor: Lin, Hsien-Chang.
502 $a Thesis (Ph.D.)--Indiana University, 2019.
506 $a This item must not be sold to any third party vendors.
520 $a As the prevalence of dementia increases in the past decades, identifying and reducing risk factors for dementia has grown in importance. Chronic non-cancer pain (CNCP) has been linked to cognitive dysfunction, but the relationships between CNCP and mild cognitive impairment (MCI) and Alzheimer's disease and related diseases (ADRDs) have not been comprehensively studied. In addition, given the accompanying detrimental effects of prescription drug misuse (PDM) on older adults' cognitive function, more information on the determinants of PDM is needed to inform evidence-based interventions. This dissertation consists of three related studies: Study 1 and Study 2 examined the impact of CNCP and pharmacological pain treatments on the risk of developing MCI/ADRD among middle-aged or older adults using an 11-year administrative claims data. Study 3 used a 20-year longitudinal cohort to examine the association of adverse childhood experiences (ACEs) with PDM in middle-aged or older adults, and investigate the mediation effect of adulthood psychosocial stressors.Study 1 revealed that CNCP patients had higher risks for MCI and ADRDs relative to non-CNCP patients. Study 2 found out that opioid use was associated with lower risks of incident MCI/ADRDs. However, a dose-response relationship between cumulative amount of opioid use and risk of ADRDs was found. Study 3 discovered the long-term impact of ACEs on PDM and revealed that the relationship between ACEs and PDM was significant mediated by adulthood psychosocial stressors.Our findings suggest that chronic pain should be carefully and effectively managed by patients and health care providers to reduce MCI and ADRDs risks. Opioid analgesics may alleviate the negative effect of CNCP on cognitive impairment but high dose of opioid should be administrated with cautions when treating CNCP. For individuals with a history of ACEs, early intervention that helps them manage stressful life circumstances in adulthood is needed to prevent PDM in their later life.
590 $a School code: 0093.
650 4 $a Public health. $3 534748
650 4 $a Gerontology. $3 533633
650 4 $a Physiology. $3 518431
650 4 $a Aging. $3 543123
650 4 $a Clinical psychology. $3 524863
650 4 $a Neurosciences. $3 588700
650 4 $a Health sciences. $3 3168359
650 4 $a Social psychology. $3 520219
650 4 $a Cognitive psychology. $3 523881
653 $a Adverse childhood experiences
653 $a Chronic pain
653 $a Dementia
653 $a Mild cognitive impairment
653 $a Prescription drug misuse
653 $a Psychosocial stressors
690 $a 0573
690 $a 0351
690 $a 0493
690 $a 0451
690 $a 0566
690 $a 0317
690 $a 0622
690 $a 0633
690 $a 0719
710 2 $a Indiana University. $b School of Public Health. $3 3169056
773 0 $t Dissertations Abstracts International $g 81-04A.
790 $a 0093
791 $a Ph.D.
792 $a 2019
793 $a English
856 4 0 $u http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=13897529