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Pharmacological and Immunological Co...

Schramm, Nathaniel.

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Pharmacological and Immunological Control of Zika Virus in Mice Deficient in Adaptive Immune Responses.

Record Type:	Electronic resources : Monograph/item
Title/Author:	Pharmacological and Immunological Control of Zika Virus in Mice Deficient in Adaptive Immune Responses./
Author:	Schramm, Nathaniel.
Published:	Ann Arbor : ProQuest Dissertations & Theses, : 2019,
Description:	68 p.
Notes:	Source: Masters Abstracts International, Volume: 80-12.
Contained By:	Masters Abstracts International80-12.
Subject:	Pharmacology. -
Online resource:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=13859162
ISBN:	9781392203590

Pharmacological and Immunological Control of Zika Virus in Mice Deficient in Adaptive Immune Responses.
Schramm, Nathaniel.

Pharmacological and Immunological Control of Zika Virus in Mice Deficient in Adaptive Immune Responses. - Ann Arbor : ProQuest Dissertations & Theses, 2019 - 68 p.

Source: Masters Abstracts International, Volume: 80-12.

Thesis (M.S.)--The University of North Carolina at Chapel Hill, 2019.

This item must not be sold to any third party vendors.

Zika virus (ZIKV) has recently demonstrated epidemic potential with prolonged infection, sexual and mother to fetus transmission, severe clinical manifestation of fetal microcephaly and congenital malformations and Guillain-Barre syndrome in adults. Existing small animal models for ZIKV infection based on interferon (IFN)-deficient mice are not well suited for long-term assessment of therapeutics. Here, we show that in contrast to immunocompetent mice that control ZIKV infection and IFN-deficient mice that rapidly succumb to infection, immunodeficient mouse strains lacking T, B, and NK cells support systemic ZIKV replication for long periods of time. Using these immunodeficient mice, we evaluated the efficacy of 7-Deaza-7-fluoro-2'-C-methyl-adenoside (DFMA), a small molecular inhibitor and a neutralizing antibody (C10) to suppress systemic ZIKV replication in vivo. DFMA treatment resulted in efficient and sustained viral suppression. Treatment with C10 also resulted in viral suppression in highly clinically relevant tissues like the brain, eyes, gastrointestinal tract, and male and female reproductive organs.

ISBN: 9781392203590Subjects--Topical Terms:

634543
Pharmacology.

Pharmacological and Immunological Control of Zika Virus in Mice Deficient in Adaptive Immune Responses.
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