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Role of Blueberry in Pancreatic beta...

Liu, Weixiang.

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Role of Blueberry in Pancreatic beta-Cells.

Record Type:	Electronic resources : Monograph/item
Title/Author:	Role of Blueberry in Pancreatic beta-Cells./
Author:	Liu, Weixiang.
Published:	Ann Arbor : ProQuest Dissertations & Theses, : 2017,
Description:	52 p.
Notes:	Source: Masters Abstracts International, Volume: 56-04.
Contained By:	Masters Abstracts International56-04(E).
Subject:	Biology. -
Online resource:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=10245995
ISBN:	9781369819946

Role of Blueberry in Pancreatic beta-Cells.
Liu, Weixiang.

Role of Blueberry in Pancreatic beta-Cells. - Ann Arbor : ProQuest Dissertations & Theses, 2017 - 52 p.

Source: Masters Abstracts International, Volume: 56-04.

Thesis (M.S.)--Michigan Technological University, 2017.

"We are what we eat." Imbalanced diet is a major reason for obesity and consequently type-2 diabetes. A healthy and attractive diet is key to the control and prevention of obesity and type-2 diabetes. Among many fruit products, blueberry is rich in bioactive substances and possesses powerful antioxidant potential, which can protect against oxidant-induced and inflammatory cell damage and cytotoxicity. Blueberry has been found to improve insulin sensitivity in muscle and adipose, and thus reduce the risk of developing type 2 diabetes. However, whether blueberry affects beta-cell function and growth were not fully evaluated.

ISBN: 9781369819946Subjects--Topical Terms:

522710
Biology.

Role of Blueberry in Pancreatic beta-Cells.
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245 1 0 $a Role of Blueberry in Pancreatic beta-Cells.
260 1 $a Ann Arbor : $b ProQuest Dissertations & Theses, $c 2017
300 $a 52 p.
500 $a Source: Masters Abstracts International, Volume: 56-04.
500 $a Adviser: Xiaoqing Tang.
502 $a Thesis (M.S.)--Michigan Technological University, 2017.
520 $a "We are what we eat." Imbalanced diet is a major reason for obesity and consequently type-2 diabetes. A healthy and attractive diet is key to the control and prevention of obesity and type-2 diabetes. Among many fruit products, blueberry is rich in bioactive substances and possesses powerful antioxidant potential, which can protect against oxidant-induced and inflammatory cell damage and cytotoxicity. Blueberry has been found to improve insulin sensitivity in muscle and adipose, and thus reduce the risk of developing type 2 diabetes. However, whether blueberry affects beta-cell function and growth were not fully evaluated.
520 $a To study the effect of the whole blueberry on beta cell function, a modified high-fat diet supplemented with 4% (wt:wt) freeze-dried whole blueberry powder (HFD+B) was applied to the C57BL/6 male mice. Compared to the mice fed with high-fat diet (HFD), the addition of blueberry had no significant change in the body weight and glucose level. Interestingly, after 8 weeks feeding, the plasma insulin level was decreased significantly in mice fed with HFD+B compared to mice fed with HFD. In addition, mice fed with HFD+B had significantly increased glucose tolerance and insulin sensitivity. Moreover, the blueberry-supplemented diet prevents HFD-induced beta-cell expansion and preserves the islet structure. Taken together, our results indicated that blueberry-supplemented diet could significantly protect beta-cell, restore HFD-induced impaired glucose homeostasis and attenuate the development of obesity, which will provide new insights into the effects of blueberry on beta-cell function and expand our understanding the importance of blueberry in treating and preventing obesity and diabetes.
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