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Detectors, Algorithms, and Scanner T...

Berg, Eric Joseph.

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Detectors, Algorithms, and Scanner Technology for Total-Body PET.

Record Type:	Electronic resources : Monograph/item
Title/Author:	Detectors, Algorithms, and Scanner Technology for Total-Body PET./
Author:	Berg, Eric Joseph.
Published:	Ann Arbor : ProQuest Dissertations & Theses, : 2016,
Description:	266 p.
Notes:	Source: Dissertation Abstracts International, Volume: 78-08(E), Section: B.
Contained By:	Dissertation Abstracts International78-08B(E).
Subject:	Medical imaging. -
Online resource:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=10195968
ISBN:	9781369615883

Detectors, Algorithms, and Scanner Technology for Total-Body PET.
Berg, Eric Joseph.

Detectors, Algorithms, and Scanner Technology for Total-Body PET. - Ann Arbor : ProQuest Dissertations & Theses, 2016 - 266 p.

Source: Dissertation Abstracts International, Volume: 78-08(E), Section: B.

Thesis (Ph.D.)--University of California, Davis, 2016.

This item is not available from ProQuest Dissertations & Theses.

The continuing growth of PET to image molecular processes in the body has spurred many technology developments, many of which have focused on new detector technology for improved spatial resolution and improved timing resolution to enable time-of-flight (TOF) reconstruction to increase image signal-to-noise. However, clinical PET image quality remains limited by the low sensitivity of the scanner. A modern PET scanner surrounds only a narrow axial segment (~ 20 cm) of the patient and collects < 1% of the annihilation photon pairs emitted from the radiotracer. To overcome the scanner's limited sensitivity, the EXPLORER consortium was formed to build the first total-body PET scanner. Rather than settling for an incremental gain in axial coverage and sensitivity, the EXPLORER scanner will cover the entire head-to-toe length of the average patient to approach the fundamental limits of PET sensitivity, providing a ~ 40-fold gain in sensitivity relative to current scanners.

ISBN: 9781369615883Subjects--Topical Terms:

3172799
Medical imaging.

Detectors, Algorithms, and Scanner Technology for Total-Body PET.
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100 1 $a Berg, Eric Joseph. $3 3287210
245 1 0 $a Detectors, Algorithms, and Scanner Technology for Total-Body PET.
260 1 $a Ann Arbor : $b ProQuest Dissertations & Theses, $c 2016
300 $a 266 p.
500 $a Source: Dissertation Abstracts International, Volume: 78-08(E), Section: B.
500 $a Adviser: Simon R. Cherry.
502 $a Thesis (Ph.D.)--University of California, Davis, 2016.
506 $a This item is not available from ProQuest Dissertations & Theses.
520 $a The continuing growth of PET to image molecular processes in the body has spurred many technology developments, many of which have focused on new detector technology for improved spatial resolution and improved timing resolution to enable time-of-flight (TOF) reconstruction to increase image signal-to-noise. However, clinical PET image quality remains limited by the low sensitivity of the scanner. A modern PET scanner surrounds only a narrow axial segment (~ 20 cm) of the patient and collects < 1% of the annihilation photon pairs emitted from the radiotracer. To overcome the scanner's limited sensitivity, the EXPLORER consortium was formed to build the first total-body PET scanner. Rather than settling for an incremental gain in axial coverage and sensitivity, the EXPLORER scanner will cover the entire head-to-toe length of the average patient to approach the fundamental limits of PET sensitivity, providing a ~ 40-fold gain in sensitivity relative to current scanners.
520 $a The focus of this work is to develop new detector and scanner technology to help realize the full potential of total-body PET. First, the scanner's long axial length implies that some photons will enter the detector at oblique angles, which leads to spatial blurring as a result of the photon's variable depth-of-interaction (DOI) in the detector. To counteract this blurring, a detector was developed that includes DOI encoding capabilities (3 mm precision), along with 440 ps timing resolution to enable TOF and comparable spatial resolution to modern detectors. This demonstrated for the first time the possibility of combined TOF-DOI capabilities in a robust, cost-effective detector suitable for total-body PET. To improve DOI encoding and timing resolution, novel signal processing methods were derived based on maximum likelihood estimation, resulting in a 30% improvement in DOI encoding and a 10% improvement in timing resolution. Further improvements in timing resolution were demonstrated by optimizing the surface treatment of the crystal detector elements, resulting in a 15% improvement in timing resolution.
520 $a Lastly, a mini-EXPLORER scanner was built to emulate total-body PET imaging in non-human primates. Many of the anticipated imaging applications that require total-body imaging capabilities demand considerable preclinical investigation before human studies; the mini-EXPLORER will facilitate preliminary studies with non-human primates. The physical performance of the scanner was assessed, and the mini-EXPLORER demonstrated large gains in sensitivity (up to 8.5% sensitivity for a monkey-sized object), along with 2 -- 3 mm reconstructed spatial resolution, and demonstrated minimal trade-offs associated with the longer scanner geometry.
590 $a School code: 0029.
650 4 $a Medical imaging. $3 3172799
650 4 $a Nuclear physics and radiation. $3 3173793
650 4 $a Biomedical engineering. $3 535387
690 $a 0574
690 $a 0756
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710 2 $a University of California, Davis. $b Biomedical Engineering. $3 1035546
773 0 $t Dissertation Abstracts International $g 78-08B(E).
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791 $a Ph.D.
792 $a 2016
793 $a English
856 4 0 $u http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=10195968