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Comparison of Sustained Cognitive Tr...

Anderson, Maria E.

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Comparison of Sustained Cognitive Training vs. Cardiovascular Exercise on Cognitive Decline and Pathology in a Vascular Model of Alzheimer's Disease.

Record Type:	Electronic resources : Monograph/item
Title/Author:	Comparison of Sustained Cognitive Training vs. Cardiovascular Exercise on Cognitive Decline and Pathology in a Vascular Model of Alzheimer's Disease./
Author:	Anderson, Maria E.
Published:	Ann Arbor : ProQuest Dissertations & Theses, : 2015,
Description:	163 p.
Notes:	Source: Dissertation Abstracts International, Volume: 77-03(E), Section: B.
Contained By:	Dissertation Abstracts International77-03B(E).
Subject:	Neurosciences. -
Online resource:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3731749
ISBN:	9781339182209

Comparison of Sustained Cognitive Training vs. Cardiovascular Exercise on Cognitive Decline and Pathology in a Vascular Model of Alzheimer's Disease.
Anderson, Maria E.

Comparison of Sustained Cognitive Training vs. Cardiovascular Exercise on Cognitive Decline and Pathology in a Vascular Model of Alzheimer's Disease. - Ann Arbor : ProQuest Dissertations & Theses, 2015 - 163 p.

Source: Dissertation Abstracts International, Volume: 77-03(E), Section: B.

Thesis (Ph.D.)--State University of New York at Stony Brook, 2015.

Despite numerous advances in our understanding of the mechanisms that underlie Alzheimer's disease (AD), there is still no cure, and the disease continues to pose a severe public health problem. It has become clear that many factors, including certain lifestyle practices, may contribute to the development of the disease; however, much remains to be learned about how lifestyle factors may prevent or delay cognitive decline. Unlike human epidemiological studies, murine models can provide clearer inferences about causality. The present studies focus on two lifestyle factors: cognitive enrichment and cardio-vascular exercise. Specifically, the effects of lifestyle interventions on behavioral performance and pathology were studied in a transgenic murine model of vascular amyloid pathology, the Tg-SwDI. The vascular component of this model's pathology is an important feature of AD pathology that shows particular promise for being responsive to these interventions. The first two studies examined the effects of a novel, progressive cognitive training intervention on pathology and behavior in three-month-old Tg-SwDI mice, as well as in a model of parenchymal amyloid (Tg-5xFAD mice). Only marginal improvements were observed in cognitive measures, without corresponding changes in gross or regional levels of amyloid pathology or in levels of regional neuroinflammation. These data do not support the value of isolated cognitive training regimens, though the feasibility of this approach in murine models is demonstrated. The final study examined the impact of four months of 1, 3, or 12-hours of voluntary cardiovascular exercise on cognitive-behavioral measures in three-month-old Tg-SwDI and healthy wild-type mice. Exercise effects were evident across multiple behavioral measures, but did not provide reliable improvement of performance across tests. Taken together, these results highlight the potential for differential susceptibility of particular features of AD to the effects of lifestyle.

ISBN: 9781339182209Subjects--Topical Terms:

588700
Neurosciences.

Comparison of Sustained Cognitive Training vs. Cardiovascular Exercise on Cognitive Decline and Pathology in a Vascular Model of Alzheimer's Disease.
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