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Innovative Approaches in Drug Discov...

Patwardhan, Bhushan.

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Innovative Approaches in Drug Discovery = Ethnopharmacology, Systems Biology and Holistic Targeting.

Record Type:	Electronic resources : Monograph/item
Title/Author:	Innovative Approaches in Drug Discovery/
Reminder of title:	Ethnopharmacology, Systems Biology and Holistic Targeting.
Author:	Patwardhan, Bhushan.
other author:	Chaguturu, Rathnam.
Published:	Saint Louis :Elsevier Science, : 2016.,
Description:	1 online resource (482 pages)
Notes:	Design and Synthesis of Natural Product Analogs (McNamara et al., 2002.
[NT 15003449]:	Front Cover; Innovative Approaches in Drug Discovery; Copyright Page; Contents; About the Editors; About the Authors; Foreword; Natural Products are Dead-Long Live Natural Products!; Preface; Dedication; 1 Drug Discovery Impasse: Pharmacognosy Holds the Key; Historical Perspectives; Synthetic Drugs; Ethnopharmacology and Natural Products; Emergence of Biotechnology; Drug Discovery Process; Drug Discovery Impasse; New Drug Approvals; Drug Recalls and Withdrawals; Why Drugs Fail?; Need for Novel Approaches; Chemical Approaches; Pharmacology Approaches; Biological Approaches.
[NT 15003449]:	Formulation DiscoveryConcluding Remarks; References; 2 Why and How Drugs Fail; Introduction; Drug Withdrawals: Analysis of Six Decades; Case Study 1: Statins; Discovery and Development of Statins; Compactin; Reduced Cholesterol Synthesis and Membrane Excitability; Isoprenoids Depletion; Role of Coenzyme Q10; Role of Selenoproteins; Role of Apoptosis, Necrosis, and Atrophy; Statin-Induced Diabetes; Case Study 2: Example of Troglitazone; Mechanism; Evidence of Toxicity; TGZ Withdrawals: European and USFDA Responses; Cytotoxic Response to Liver Cells: Probable Role of Mitochondrial Injury.
[NT 15003449]:	Inhibition of Bile Salt Export Pump (BSEP)Formation of Electrophilic Reactive Intermediates; Role of Host-Related Factors; Case Study 3: Example of Rofecoxib; Development of Vioxx; Discovery of the First NSAID-Aspirin; Mechanism of Action; Preclinical and Clinical Studies; The Downfall of Vioxx; Major Studies Postapproval; Withdrawal of Vioxx: The "Blockbuster" Drug; Rofecoxib and Cardiovascular Toxicity: Role of On-Target, Off-Target, and Intrinsic Chemical Properties; Case Study 4: Example of Thalidomide; Conclusions and Future Perspectives; References; 3 Holistic Drug Targeting.
[NT 15003449]:	IntroductionSingle-Target Specificity Approach; Target Identification and Validation; Chemical Genetics; High Throughput Screening (HTS) of Druggable Targets; Rational Drug Design; Pharmacognosy; Target to Lead Bottleneck; Biological Redundancy and the Holistic Advantage; Approaches for Holistic Drug Targeting; Drug Repositioning; Combination Therapy; Multitarget Drug Discovery; Concluding Remarks; References; 4 Reverse Pharmacology; Introduction and Background; Introduction; Background of Reverse Pharmacology; The Roots of Modern Drugs in Traditional Remedies/Poisons.
[NT 15003449]:	The Definition of Reverse Pharmacology and Its Different OriginsAyurvedic Pharmacoepidemiology and Observational Therapeutics; Ayurvedic Pharmacoepidemiology; Observational Therapeutics; Clinical Study Designs and Para-Clinical Models in Reverse Pharmacology; Ayurveda-Inspired Hits and Leads for New Drug Discoveries; Discovery of Natural Products-Based New Chemical Entities via Chemistry and Chemical Biology Technologies; Introduction and Background; Isolation of Natural Products from Plant Species with Established Indian Folk Medicine Properties; Sample Collection; Fractionation.
Subject:	Pharmacology. -
Online resource:	http://www.sciencedirect.com/science/book/9780128018149
ISBN:	9780128018224

Innovative Approaches in Drug Discovery = Ethnopharmacology, Systems Biology and Holistic Targeting.
Patwardhan, Bhushan.

Innovative Approaches in Drug DiscoveryEthnopharmacology, Systems Biology and Holistic Targeting.[electronic resource] : - Saint Louis :Elsevier Science,2016. - 1 online resource (482 pages)

Design and Synthesis of Natural Product Analogs (McNamara et al., 2002.

Front Cover; Innovative Approaches in Drug Discovery; Copyright Page; Contents; About the Editors; About the Authors; Foreword; Natural Products are Dead-Long Live Natural Products!; Preface; Dedication; 1 Drug Discovery Impasse: Pharmacognosy Holds the Key; Historical Perspectives; Synthetic Drugs; Ethnopharmacology and Natural Products; Emergence of Biotechnology; Drug Discovery Process; Drug Discovery Impasse; New Drug Approvals; Drug Recalls and Withdrawals; Why Drugs Fail?; Need for Novel Approaches; Chemical Approaches; Pharmacology Approaches; Biological Approaches.

ISBN: 9780128018224Subjects--Topical Terms:

634543
Pharmacology.
Index Terms--Genre/Form:

542853
Electronic books.

LC Class. No.: RM300.P389 2016

Dewey Class. No.: 615.1

Innovative Approaches in Drug Discovery = Ethnopharmacology, Systems Biology and Holistic Targeting.
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003 OCoLC
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020 $a 9780128018224 $q (ebook)
020 $a 9780128018149 $q (pbk.)
020 $a 0128018224
035 $a (OCoLC)961452133
035 $a ocn961452133
040 $a EBLCP $b eng $e pn $c EBLCP $d OCLCQ $d NDHU
050 # 4 $a RM300.P389 2016
082 0 4 $a 615.1
100 1 $a Patwardhan, Bhushan. $3 3208424
245 1 0 $a Innovative Approaches in Drug Discovery $h [electronic resource] : $b Ethnopharmacology, Systems Biology and Holistic Targeting.
260 # $a Saint Louis : $b Elsevier Science, $c 2016.
300 $a 1 online resource (482 pages)
500 $a Design and Synthesis of Natural Product Analogs (McNamara et al., 2002.
505 0 # $a Front Cover; Innovative Approaches in Drug Discovery; Copyright Page; Contents; About the Editors; About the Authors; Foreword; Natural Products are Dead-Long Live Natural Products!; Preface; Dedication; 1 Drug Discovery Impasse: Pharmacognosy Holds the Key; Historical Perspectives; Synthetic Drugs; Ethnopharmacology and Natural Products; Emergence of Biotechnology; Drug Discovery Process; Drug Discovery Impasse; New Drug Approvals; Drug Recalls and Withdrawals; Why Drugs Fail?; Need for Novel Approaches; Chemical Approaches; Pharmacology Approaches; Biological Approaches.
505 8 # $a Formulation DiscoveryConcluding Remarks; References; 2 Why and How Drugs Fail; Introduction; Drug Withdrawals: Analysis of Six Decades; Case Study 1: Statins; Discovery and Development of Statins; Compactin; Reduced Cholesterol Synthesis and Membrane Excitability; Isoprenoids Depletion; Role of Coenzyme Q10; Role of Selenoproteins; Role of Apoptosis, Necrosis, and Atrophy; Statin-Induced Diabetes; Case Study 2: Example of Troglitazone; Mechanism; Evidence of Toxicity; TGZ Withdrawals: European and USFDA Responses; Cytotoxic Response to Liver Cells: Probable Role of Mitochondrial Injury.
505 8 # $a Inhibition of Bile Salt Export Pump (BSEP)Formation of Electrophilic Reactive Intermediates; Role of Host-Related Factors; Case Study 3: Example of Rofecoxib; Development of Vioxx; Discovery of the First NSAID-Aspirin; Mechanism of Action; Preclinical and Clinical Studies; The Downfall of Vioxx; Major Studies Postapproval; Withdrawal of Vioxx: The "Blockbuster" Drug; Rofecoxib and Cardiovascular Toxicity: Role of On-Target, Off-Target, and Intrinsic Chemical Properties; Case Study 4: Example of Thalidomide; Conclusions and Future Perspectives; References; 3 Holistic Drug Targeting.
505 8 # $a IntroductionSingle-Target Specificity Approach; Target Identification and Validation; Chemical Genetics; High Throughput Screening (HTS) of Druggable Targets; Rational Drug Design; Pharmacognosy; Target to Lead Bottleneck; Biological Redundancy and the Holistic Advantage; Approaches for Holistic Drug Targeting; Drug Repositioning; Combination Therapy; Multitarget Drug Discovery; Concluding Remarks; References; 4 Reverse Pharmacology; Introduction and Background; Introduction; Background of Reverse Pharmacology; The Roots of Modern Drugs in Traditional Remedies/Poisons.
505 8 # $a The Definition of Reverse Pharmacology and Its Different OriginsAyurvedic Pharmacoepidemiology and Observational Therapeutics; Ayurvedic Pharmacoepidemiology; Observational Therapeutics; Clinical Study Designs and Para-Clinical Models in Reverse Pharmacology; Ayurveda-Inspired Hits and Leads for New Drug Discoveries; Discovery of Natural Products-Based New Chemical Entities via Chemistry and Chemical Biology Technologies; Introduction and Background; Isolation of Natural Products from Plant Species with Established Indian Folk Medicine Properties; Sample Collection; Fractionation.
588 0 $a Print version record.
650 # 4 $a Pharmacology. $3 634543
655 # 4 $a Electronic books. $2 lcsh $3 542853
700 1 # $a Chaguturu, Rathnam. $3 2148524
776 0 8 $i Print version: $a Patwardhan, Bhushan. $t Innovative Approaches in Drug Discovery : Ethnopharmacology, Systems Biology and Holistic Targeting. $d Saint Louis : Elsevier Science, ©2016 $z 9780128018149
856 7 # $u http://www.sciencedirect.com/science/book/9780128018149 $2 http