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Synthesis and Solution Self-Assembly...

Petretic, Amy.

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Synthesis and Solution Self-Assembly of Poly(L-Lactide)-Based Amphiphilic Block Copolymers.

Record Type:	Electronic resources : Monograph/item
Title/Author:	Synthesis and Solution Self-Assembly of Poly(L-Lactide)-Based Amphiphilic Block Copolymers./
Author:	Petretic, Amy.
Description:	116 p.
Notes:	Source: Masters Abstracts International, Volume: 55-01.
Contained By:	Masters Abstracts International55-01(E).
Subject:	Polymer chemistry. -
Online resource:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=1599083
ISBN:	9781339051086

Synthesis and Solution Self-Assembly of Poly(L-Lactide)-Based Amphiphilic Block Copolymers.
Petretic, Amy.

Synthesis and Solution Self-Assembly of Poly(L-Lactide)-Based Amphiphilic Block Copolymers. - 116 p.

Source: Masters Abstracts International, Volume: 55-01.

Thesis (M.Sc.)--University of Toronto (Canada), 2015.

Nanostructures based on biocompatible and biodegradable polymers are desirable for numerous biomedical applications. An amphiphilic block copolymer, poly(L-lactide)-b-poly(acrylic acid) (PLLA-b-PAA), was synthesized by combination of ring-opening polymerization (ROP) of L-lactide and reversible-addition fragmentation chain transfer (RAFT) polymerization of tert-butyl acrylate, a protected acrylic acid. Methoxy-terminated poly(ethylene glycol)-amine, a protein-repellent polymer, was conjugated to a portion of the PAA block to prepare a brush copolymer, PLLA-b-P(AA- r-PEGAm). The self-assembly of these amphiphilic block copolymers was explored in dilute aqueous solution using a solvent-switch method. A number of morphologies were observed when the self-assembly conditions (e.g., solvent, concentration, temperature) were varied. These structures included fibers, lozenges, and intermediate fiber-lozenge structures. The most intriguing result was that PLLA-b-PAA formed well-defined lozenge-shaped structures when the self-assembly was performed at 55 °C. The --COOH groups on the PAA corona of the micelles were used to coordinate to cisplatin, demonstrating the potential of the micelles to be employed as nanocarriers for drug delivery.

ISBN: 9781339051086Subjects--Topical Terms:

3173488
Polymer chemistry.

Synthesis and Solution Self-Assembly of Poly(L-Lactide)-Based Amphiphilic Block Copolymers.
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245 1 0 $a Synthesis and Solution Self-Assembly of Poly(L-Lactide)-Based Amphiphilic Block Copolymers.
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500 $a Adviser: Mitchell A. Winnik.
502 $a Thesis (M.Sc.)--University of Toronto (Canada), 2015.
520 $a Nanostructures based on biocompatible and biodegradable polymers are desirable for numerous biomedical applications. An amphiphilic block copolymer, poly(L-lactide)-b-poly(acrylic acid) (PLLA-b-PAA), was synthesized by combination of ring-opening polymerization (ROP) of L-lactide and reversible-addition fragmentation chain transfer (RAFT) polymerization of tert-butyl acrylate, a protected acrylic acid. Methoxy-terminated poly(ethylene glycol)-amine, a protein-repellent polymer, was conjugated to a portion of the PAA block to prepare a brush copolymer, PLLA-b-P(AA- r-PEGAm). The self-assembly of these amphiphilic block copolymers was explored in dilute aqueous solution using a solvent-switch method. A number of morphologies were observed when the self-assembly conditions (e.g., solvent, concentration, temperature) were varied. These structures included fibers, lozenges, and intermediate fiber-lozenge structures. The most intriguing result was that PLLA-b-PAA formed well-defined lozenge-shaped structures when the self-assembly was performed at 55 °C. The --COOH groups on the PAA corona of the micelles were used to coordinate to cisplatin, demonstrating the potential of the micelles to be employed as nanocarriers for drug delivery.
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