東華大學圖書館 |

語系: 繁體中文

說明(常見問題)

回圖書館首頁

手機版館藏查詢

登入

回首頁 到查詢結果 [ null ]

切換: 標籤 | MARC模式 | ISBD

Ion channel gene expression as objec...

VanHaitsma, Timothy Allen.

FindBook

Google Book

Amazon

博客來

Ion channel gene expression as objective biomarkers of training induced fatigue.

紀錄類型:	書目-電子資源 : Monograph/item
正題名/作者:	Ion channel gene expression as objective biomarkers of training induced fatigue./
作者:	VanHaitsma, Timothy Allen.
面頁冊數:	102 p.
附註:	Source: Dissertation Abstracts International, Volume: 76-06(E), Section: B.
Contained By:	Dissertation Abstracts International76-06B(E).
標題:	Kinesiology. -
電子資源:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3681816
ISBN:	9781321547993

Ion channel gene expression as objective biomarkers of training induced fatigue.
VanHaitsma, Timothy Allen.

Ion channel gene expression as objective biomarkers of training induced fatigue. - 102 p.

Source: Dissertation Abstracts International, Volume: 76-06(E), Section: B.

Thesis (Ph.D.)--The University of Utah, 2014.

The conditions and mechanisms that produce decrements in exercise performance have been an important area of research for decades. However, the sensation of fatigue that may persist for hours or days after exercise has received less attention. This long-lasting fatigue sensation is common in clinical populations. In chronic fatigue syndrome (CFS), moderate physical activity can produce increased fatigue sensations that last for several days. A recent study of CFS patients demonstrated significant increases in fatigue and pain sensations that were closely related to gene expression changes in metabolite-detecting, adrenergic, and immune markers following 25 minutes of moderate, whole body exercise. This exercise stimulus did not produce long-lasting fatigue or changes in gene expression in healthy age and gender-matched controls.

ISBN: 9781321547993Subjects--Topical Terms:

517627
Kinesiology.

Ion channel gene expression as objective biomarkers of training induced fatigue.
LDR:03947nmm a2200289 4500 001 2068473
005 20160422121601.5
008 170521s2014 ||||||||||||||||| ||eng d
020 $a 9781321547993
035 $a (MiAaPQ)AAI3681816
035 $a AAI3681816
040 $a MiAaPQ $c MiAaPQ
100 1 $a VanHaitsma, Timothy Allen. $3 3183418
245 1 0 $a Ion channel gene expression as objective biomarkers of training induced fatigue.
300 $a 102 p.
500 $a Source: Dissertation Abstracts International, Volume: 76-06(E), Section: B.
500 $a Adviser: Andrea T. White.
502 $a Thesis (Ph.D.)--The University of Utah, 2014.
520 $a The conditions and mechanisms that produce decrements in exercise performance have been an important area of research for decades. However, the sensation of fatigue that may persist for hours or days after exercise has received less attention. This long-lasting fatigue sensation is common in clinical populations. In chronic fatigue syndrome (CFS), moderate physical activity can produce increased fatigue sensations that last for several days. A recent study of CFS patients demonstrated significant increases in fatigue and pain sensations that were closely related to gene expression changes in metabolite-detecting, adrenergic, and immune markers following 25 minutes of moderate, whole body exercise. This exercise stimulus did not produce long-lasting fatigue or changes in gene expression in healthy age and gender-matched controls.
520 $a The graded exercise test (GXT) is commonly applied in CFS research. Although intense, the GXT rarely produces long-lasting fatigue in healthy individuals and its effect on CFS patients' postexertional fatigue is unclear. Thus, the goals of these studies were to examine gene expression and fatigue sensations in healthy, trained individuals during and after three different exercise stressors: a GXT, a 40k time trial in ambient conditions (AT), and the same time trial in adverse, hot conditions (HT). It was hypothesized that there would be larger changes in gene expression following both AT and HT, compared to GXT. The first study explored the differences in gene expression following GXT and AT. Following AT, there were larger decreases in metabolite-detecting mRNA, larger increases in adrenergic, immunologic, and serotonin mRNA as compared to GXT. Further, these gene expression changes were different from postexercise responses of CFS patients. The goal of the second study was to add an additional stressor to the 40k time trial -- heat. Because TRPV receptors are sensitive to heat, it was thought that the heat stress would cause larger increases in TRPV mRNA. However, because exercise power was reduced during HT, there were no differences in gene expression between the two trials except that IL6 mRNA decreased significantly more following AT compared to HT. Collectively, these results show that gene expression in healthy individuals is affected by the intensity and length of the exercise. The decreases in metabolite-detecting mRNA are thought to be an attempt to restore homeostasis in the fatigue and pain detecting receptors. The fact that there was no difference between AT and HT suggests that heat is an additional metabolite that activates the metabolite-detecting receptors, helping to regulate the intensity of exercise and the amount of fatigue during exercise. Adrenergic receptors increased, possibly causing a decrease in blood flow following exercise and increasing the resting levels of metabolites and subsequently increasing the resting fatigue signal. The change in the ratio of serotonin/dopamine may also contribute to the increased fatigue sensation following exercise.
590 $a School code: 0240.
650 4 $a Kinesiology. $3 517627
650 4 $a Physiology. $3 518431
690 $a 0575
690 $a 0719
710 2 $a The University of Utah. $b Exercise and Sport Science. $3 1674557
773 0 $t Dissertation Abstracts International $g 76-06B(E).
790 $a 0240
791 $a Ph.D.
792 $a 2014
793 $a English
856 4 0 $u http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3681816