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Birth defects among surviving childr...

Wang, Baoguang.

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Birth defects among surviving children under seven years of age in Tianjin, China.

Record Type:	Electronic resources : Monograph/item
Title/Author:	Birth defects among surviving children under seven years of age in Tianjin, China./
Author:	Wang, Baoguang.
Description:	133 p.
Notes:	Source: Dissertation Abstracts International, Volume: 58-09, Section: B, page: 4745.
Contained By:	Dissertation Abstracts International58-09B.
Subject:	Public health. -
Online resource:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=9809553
ISBN:	9780591600292

Birth defects among surviving children under seven years of age in Tianjin, China.
Wang, Baoguang.

Birth defects among surviving children under seven years of age in Tianjin, China. - 133 p.

Source: Dissertation Abstracts International, Volume: 58-09, Section: B, page: 4745.

Thesis (Dr.P.H.)--The University of Texas School of Public Health, 1997.

Birth defects are a leading cause of infant mortality in the developed countries. They are also of increasing concern in many developing countries, such as China. However, prevalence and causes of birth defects in China are inadequately understood.

ISBN: 9780591600292Subjects--Topical Terms:

534748
Public health.

Birth defects among surviving children under seven years of age in Tianjin, China.
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100 1 $a Wang, Baoguang. $3 3183080
245 1 0 $a Birth defects among surviving children under seven years of age in Tianjin, China.
300 $a 133 p.
500 $a Source: Dissertation Abstracts International, Volume: 58-09, Section: B, page: 4745.
500 $a Supervisor: Kim D. Waller.
502 $a Thesis (Dr.P.H.)--The University of Texas School of Public Health, 1997.
520 $a Birth defects are a leading cause of infant mortality in the developed countries. They are also of increasing concern in many developing countries, such as China. However, prevalence and causes of birth defects in China are inadequately understood.
520 $a The purpose of the present study was to estimated prevalence of birth defects in surviving children under seven years of age in Tianjin, China and investigate determinants of birth defects in the study area.
520 $a The present study took place in Tianjin, China in 1986, involving 22,081 surviving children under seven years of age. Children with birth defects were ascertained through physical examinations by physicians during household visits and ascertainment of birth defects was verified through multiple sources. Of 22,081 surviving children, 524 had birth defects (23.7 per 1,000). The study noted a striking discrepancy in the prevalence of birth defects between urban and rural area. The prevalence of birth defects was 16.3 per 1,000 in the urban and 33.2 per 1,000 in the rural area.
520 $a Using cases of birth defects ascertained from surviving children, a case-control study was carried out. The study observed that first-trimester maternal flu was associated with increased risk of both major and minor birth defects in children after controlling for other maternal factors (adjusted odds ratio (OR) = 8.7, 95% confidence interval (CI) = 4.3-17.3; OR = 3.6, 95% CI = 1.7-7.5). This association could be biased by different reporting of exposure between mothers of children with birth defects and mothers of children without defects. This study indicated that maternal flu was also associated with congenital heart defects and polydactyly after controlling for other maternal factors (adjusted OR = 32.3, 95% CI = 13.3-78.3; adjusted OR = 5.5, 95% CI = 1.1-27.7). The associations remained when affected controls (children with similar birth defects other than congenital heart defects or polydactyly) were used (adjusted OR = 4.3, 95% CI = 1.2-15.3; OR = 1.4, 95% CI = 1.4-7.9). A weak association between first-trimester vaginal bleeding and selected groups of birth defects was found in this study, but the association may be confounded by other factors. Maternal smoking during pregnancy was modestly associated with cleft lip with or without cleft palate (OR = 1.4, 95% = 0.4-4.9), but the association may be due to chance. Some major limitations in this study warrant caution in interpretation of the findings, especially the causal relation.
590 $a School code: 0219.
650 4 $a Public health. $3 534748
650 4 $a Obstetrics. $3 634501
650 4 $a Genetics. $3 530508
690 $a 0573
690 $a 0380
690 $a 0369
710 2 $a The University of Texas School of Public Health. $3 1023950
773 0 $t Dissertation Abstracts International $g 58-09B.
790 $a 0219
791 $a Dr.P.H.
792 $a 1997
793 $a English
856 4 0 $u http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=9809553