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Solvent -free fabrication of porous ...

Wang, Xiaoxi.

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Solvent -free fabrication of porous polymer for tissue engineering applications.

Record Type:	Electronic resources : Monograph/item
Title/Author:	Solvent -free fabrication of porous polymer for tissue engineering applications./
Author:	Wang, Xiaoxi.
Description:	188 p.
Notes:	Source: Dissertation Abstracts International, Volume: 68-11, Section: B, page: 7483.
Contained By:	Dissertation Abstracts International68-11B.
Subject:	Biomedical engineering. -
Online resource:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3290615
ISBN:	9780549344469

Solvent -free fabrication of porous polymer for tissue engineering applications.
Wang, Xiaoxi.

Solvent -free fabrication of porous polymer for tissue engineering applications. - 188 p.

Source: Dissertation Abstracts International, Volume: 68-11, Section: B, page: 7483.

Thesis (Ph.D.)--University of Washington, 2007.

This item must not be sold to any third party vendors.

Tissue engineering scaffold is one of the basic components of all tissue engineering approaches. Most of the existing fabrication techniques for tissue engineering scaffolds require the use of organic solvents that may never be fully removed, even after long processing hours. The residuals of these organic solvents reduce the ability of cells to form new tissues in vivo. In this research, a solvent-free approach to fabricating porous polymers was developed for potential tissue engineering applications. The method includes solid-state foaming and ultrasound treatment.

ISBN: 9780549344469Subjects--Topical Terms:

535387
Biomedical engineering.

Solvent -free fabrication of porous polymer for tissue engineering applications.
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020 $a 9780549344469
035 $a (MiAaPQ)AAI3290615
035 $a AAI3290615
040 $a MiAaPQ $c MiAaPQ
100 1 $a Wang, Xiaoxi. $3 2134182
245 1 0 $a Solvent -free fabrication of porous polymer for tissue engineering applications.
300 $a 188 p.
500 $a Source: Dissertation Abstracts International, Volume: 68-11, Section: B, page: 7483.
500 $a Advisers: Wei Li; Vipin Kumar.
502 $a Thesis (Ph.D.)--University of Washington, 2007.
506 $a This item must not be sold to any third party vendors.
506 $a This item must not be added to any third party search indexes.
520 $a Tissue engineering scaffold is one of the basic components of all tissue engineering approaches. Most of the existing fabrication techniques for tissue engineering scaffolds require the use of organic solvents that may never be fully removed, even after long processing hours. The residuals of these organic solvents reduce the ability of cells to form new tissues in vivo. In this research, a solvent-free approach to fabricating porous polymers was developed for potential tissue engineering applications. The method includes solid-state foaming and ultrasound treatment.
520 $a PLA (Polylactic acid), one of the most popular materials in tissue engineering applications, was investigated. The PLA-CO2 system was characterized in this study for the solid-state foaming process with a particular goal of producing low density foams. The results show that low relative density foams (lower than 10%) could be achieved in a wide processing window. To better control the solid-state foaming process and tailor the material properties, a systematic study was carried out on the crystallization behavior of PLA at different stages of the solid-state foaming process. It is found that crystallinity increased linearly with the square root of the area strain of the porous structures.
520 $a Ultrasound of 20 and 40 kHz was applied to the solid-state foams. Both dye diffusion tests and permeability measurements show that ultrasound could enhance the interconnectivity of solid-state foams. Effects of ultrasound processing time, ultrasound frequency, ultrasound power, bath temperature, and pore size were investigated. For PLA and PETG (Polyethylene Terephthalate Glycol) foams, interconnected microstructures were obtained, with permeability on the level of 10-12 m2 or higher for the pore sizes ranging from 230 mum to 430 mum.
520 $a Ultrasound heating in the specimen was studied. The maximum temperature induced by the ultrasound heating was found to be below the Tg of PLA. It is proposed that ultrasound cavitation is the dominant mechanism responsible for the permeability enhancement of the solid-state foams. A quantitative model was constructed to help understand the effects of pore size and bath temperature that have been observed in the experimental study. Pore wall break inside the foam is considered to be a fatigue failure caused by ultrasound cavitation events.
590 $a School code: 0250.
650 4 $a Biomedical engineering. $3 535387
650 4 $a Materials science. $3 543314
690 $a 0541
690 $a 0794
710 2 $a University of Washington. $3 545923
773 0 $t Dissertation Abstracts International $g 68-11B.
790 $a 0250
791 $a Ph.D.
792 $a 2007
793 $a English
856 4 0 $u http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3290615